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Here, we quantified contrast sensitivity in 99 people (20\u201388 years): 52 with eye diseases (10 with early AMD, 9 diabetics without retinopathy, 22 glaucoma suspects, 11 high myopes) and 47 age-matched healthy controls using a new spatial vision chart (0.28\u2013100% Weber contrasts; 3\u201360\u2009c\/\u00b0 frequencies). In retinal diseases and healthy ageing, the chart detected frequency-dependent losses; sensitivity was reduced at 3 and 8\u2009c\/\u00b0 in AMD, at 6 and 8\u2009c\/\u00b0 in diabetes, and at all frequencies in myopia and with ageing. Intrasession repeatability was excellent and spatial contrast changes were in accordance with deficits identified previously using complex and time-consuming psychophysical tests. The chart offers a simple, rapid and readily available tool for clinical use to document early visual deficits.<\/jats:p>","DOI":"10.1136\/bjo-2024-326490","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T13:35:44Z","timestamp":1742996144000},"page":"1088-1090","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Rapid clinical assessment of spatial contrast sensitivity changes in retinal disease and ageing"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-8500","authenticated-orcid":false,"given":"Prakash","family":"Adhikari","sequence":"first","affiliation":[{"name":"Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Zele","sequence":"additional","affiliation":[{"name":"Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Feigl","sequence":"additional","affiliation":[{"name":"Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland, Australia"},{"name":"School of Clinical Medicine, Queensland University of Technology (QUT), Brisbane, Queensland, Australia"},{"name":"Queensland Eye Institute, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"2025082002151086000_109.9.1088.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101160"},{"key":"2025082002151086000_109.9.1088.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.62.4.198"},{"key":"2025082002151086000_109.9.1088.3","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-198406000-00011"},{"key":"2025082002151086000_109.9.1088.4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130061028"},{"key":"2025082002151086000_109.9.1088.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.66.8.492"},{"key":"2025082002151086000_109.9.1088.6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1569"},{"key":"2025082002151086000_109.9.1088.7","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(93)90077-A"},{"key":"2025082002151086000_109.9.1088.8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.62.4.213"},{"key":"2025082002151086000_109.9.1088.9","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13083"},{"key":"2025082002151086000_109.9.1088.10","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12914"},{"key":"2025082002151086000_109.9.1088.11","first-page":"469","article-title":"Macular function impairment in eyes with early age-related macular degeneration","volume":"38","author":"Midena","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2025082002151086000_109.9.1088.12","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.74.12.712"},{"key":"2025082002151086000_109.9.1088.13","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(76)90214-5"},{"key":"2025082002151086000_109.9.1088.14","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1570"},{"key":"2025082002151086000_109.9.1088.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38012-9"},{"key":"2025082002151086000_109.9.1088.16","unstructured":"American Academy of Ophthalmology Glaucoma Panel . Preferred practice pattern guidelines. In: Primary open-angle glaucoma suspect. San Francisco: CA: American Academy of Ophthalmology, 2010. 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