{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:14:47Z","timestamp":1789906487790,"version":"4.0.1"},"reference-count":35,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["311252\/Z\/24\/Z Wellcome"],"award-info":[{"award-number":["311252\/Z\/24\/Z Wellcome"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CS-2018-18-ST2-005"],"award-info":[{"award-number":["CS-2018-18-ST2-005"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,1,20]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We aimed to provide, through the Uveitis in Childhood National Cohort Study, population-based evidence on incidence, distribution and disease characteristics for childhood onset non-infectious uveitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eligible children and young people (&lt;18 years) were those newly diagnosed with non-infectious uveitis between 1 March 2020 and 28 February 2023. Cases were identified and recruited through passive surveillance across a multicentre network. Descriptive analysis of demographic, socioeconomic and clinical characteristics at diagnosis is reported alongside incidence rates, relative rates by region and sociodemographic patterning.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>468 cases were identified, providing a minimal national disease incidence of 1.89\/100 000 (95% CI 1.72 to 2.07). Among the 255 children recruited, anterior uveitis was predominant (76.9%) and 65% of cases were bilateral. Peak incidence was at 11\u201315 years. Children resident in deprived areas and those from non-White ethnic backgrounds were over-represented (28% and 31% of the cohort). One in seven children (15%) had a diagnosis of juvenile idiopathic arthritis (JIA), and 5% had tubulointerstitial nephritis. Although bilaterally poor vision was uncommon (16.8%), 44.3% had lost some vision in at least one eye.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There is a need to reconsider how best to deliver paediatric rheumatological and eye care that meets the needs of young people, as well as young children, with uveitis. The predominance of non-JIA-related uveitis calls for a shift in focus. There appears to be socioeconomic drivers of disease risk, which are worthy of future exploration and which have implications on the delivery of care for this chronic and blinding disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2024-326674","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T03:43:58Z","timestamp":1739331838000},"page":"955-961","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence, sociodemographic and presenting clinical features of childhood non-infectious uveitis: findings from the UK national inception cohort study"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-5864","authenticated-orcid":false,"given":"Ameenat Lola","family":"Solebo","sequence":"first","affiliation":[{"name":"Population Policy and Practice Research and Teaching Department, UCL GOS Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salomey","family":"Kellett","sequence":"additional","affiliation":[{"name":"UCL GOS Institute of Child Health, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eibhlin","family":"McLoone","sequence":"additional","affiliation":[{"name":"Ophthalmology, Royal Victoria Hospital, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Petrushkin","sequence":"additional","affiliation":[{"name":"Uveitis and Scleritis Service, Moorfields Eye Hospital NHS Foundation Trust, London, London, UK"},{"name":"Rheumatology, Great Ormond Street Hospital for Children, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-8590","authenticated-orcid":false,"given":"Jose","family":"Gonzalez-Martin","sequence":"additional","affiliation":[{"name":"Paediatric Ophthalmology, Alder Hey Children's NHS Foundation Trust, Liverpool, Merseyside, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital, Manchester University Hospitals NHS Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessy","family":"Choi","sequence":"additional","affiliation":[{"name":"Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-8255","authenticated-orcid":false,"given":"Rachel F","family":"Pilling","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Bradford Royal Infirmary, Bradford, West Yorkshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Armon","sequence":"additional","affiliation":[{"name":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Warrier","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0143-3994","authenticated-orcid":false,"given":"Srilakshmi M","family":"Sharma","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5718-9209","authenticated-orcid":false,"given":"Jugnoo S","family":"Rahi","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"2025100901550815000_109.8.955.1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12491"},{"key":"2025100901550815000_109.8.955.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.1.51"},{"key":"2025100901550815000_109.8.955.3","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24551"},{"key":"2025100901550815000_109.8.955.4","article-title":"Paediatric autoimmune and autoinflammatory conditions associated with uveitis","volume":"12","author":"Rahman","year":"2020","journal-title":"Ther Adv Ophthalmol"},{"key":"2025100901550815000_109.8.955.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02148-7"},{"key":"2025100901550815000_109.8.955.6","article-title":"Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis-associated uveitis","volume":"10","author":"Renton","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"2025100901550815000_109.8.955.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0518-8"},{"key":"2025100901550815000_109.8.955.8","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2017.1305420"},{"key":"2025100901550815000_109.8.955.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-01267-2"},{"key":"2025100901550815000_109.8.955.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102266"},{"key":"2025100901550815000_109.8.955.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113682"},{"key":"2025100901550815000_109.8.955.12","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2021.1976215"},{"key":"2025100901550815000_109.8.955.13","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.26689.1","article-title":"UNICORNS: Uveitis in childhood prospective national cohort study protocol","volume":"9","author":"Kellett","year":"2020","journal-title":"F1000Res"},{"key":"2025100901550815000_109.8.955.14","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.881398","article-title":"Development of a Nationally Agreed Core Clinical Dataset for Childhood Onset Uveitis","volume":"10","author":"Solebo","year":"2022","journal-title":"Front Pediatr"},{"key":"2025100901550815000_109.8.955.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"2025100901550815000_109.8.955.16","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2003.013011"},{"key":"2025100901550815000_109.8.955.17","unstructured":"Office for National Statistics . Population estimates for UK, England and503 wales, Scotland and Northern Ireland. 2021. Available: https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/populationandmigration\/populationestimates\/bulletins\/annualmidyearpopulationestimates\/mid2021 [Accessed 19 Sep 2024]."},{"key":"2025100901550815000_109.8.955.18","doi-asserted-by":"crossref","DOI":"10.1016\/S2665-9913(24)00271-6","article-title":"Inclusive study design to better serve the needs of children and young people with rheumatological conditions","volume":"6","author":"Solebo","year":"2024","journal-title":"Lancet Rheumatol"},{"key":"2025100901550815000_109.8.955.19","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.682327","article-title":"Long Term Experience in Patients With JIA-Associated Uveitis in a Large Referral Center","volume":"9","author":"Marelli","year":"2021","journal-title":"Front Pediatr"},{"key":"2025100901550815000_109.8.955.20","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.221092"},{"key":"2025100901550815000_109.8.955.21","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.12.1428"},{"key":"2025100901550815000_109.8.955.22","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/S0140-6736(12)60072-5","article-title":"Adolescence: a foundation for future health","volume":"379","author":"Sawyer","year":"2012","journal-title":"The Lancet"},{"key":"2025100901550815000_109.8.955.23","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30163-8"},{"key":"2025100901550815000_109.8.955.24","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130302"},{"key":"2025100901550815000_109.8.955.25","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead700"},{"key":"2025100901550815000_109.8.955.26","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00323-5"},{"key":"2025100901550815000_109.8.955.27","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323470"},{"key":"2025100901550815000_109.8.955.28","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S2352-4642(18)30317-1","article-title":"5-year outcomes after primary intraocular lens implantation in children aged 2 years or younger with congenital or infantile cataract: findings from the IoLunder2 prospective inception cohort study","volume":"2","author":"Solebo","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"2025100901550815000_109.8.955.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.02.038"},{"key":"2025100901550815000_109.8.955.30","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4522"},{"key":"2025100901550815000_109.8.955.31","first-page":"1403","article-title":"Chronic uveitis in children with and without juvenile idiopathic arthritis: differences in patient characteristics and clinical course","volume":"35","author":"Heinz","year":"2008","journal-title":"J Rheumatol"},{"key":"2025100901550815000_109.8.955.32","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2000.078001084.x"},{"key":"2025100901550815000_109.8.955.33","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12786"},{"key":"2025100901550815000_109.8.955.34","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1736311"},{"key":"2025100901550815000_109.8.955.35","doi-asserted-by":"publisher","DOI":"10.1002\/ped4.12362"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2024-326674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:56:20Z","timestamp":1760000180000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2024-326674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,7,22]]},"published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1136\/bjo-2024-326674"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2024-326674","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,11]]}}}