{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:27:05Z","timestamp":1793060825092,"version":"4.5.0"},"reference-count":26,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"HOYA","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,4,23]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate and compare the efficacy of combination treatment using 0.025% atropine and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses to 0.025% atropine and single vision (SV) spectacle lenses in slowing myopia progression in children with myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomised controlled trial conducted on children aged 4\u201316 years with myopia between \u22121.00D and \u22126.00D and astigmatism \u22642.00D. Children were randomly allocated into two groups: 0.025% atropine and SV spectacle lenses treatment group (group A), and 0.025% atropine and DIMS spectacle lenses treatment group (group B). Cycloplegic spherical equivalent refraction (SER) and axial length were measured at baseline, 6 and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>102 patients completed the 12-month follow-up: n=49 in group A, mean age 9.50\u00b12.78 years and n=53 in group B, mean age 9.90\u00b12.47 years. At 12 months, the mean AL\u00b1SD change was 0.18\u00b10.16\u2009mm in group A and 0.07\u00b10.16\u2009mm in group B (mean difference: 0.11, 95%\u2009CI: 0.05 to 0.17; p\u22640.001). Mean SER\u00b1SD progression at 12 months was \u22120.19\u00b10.42D and \u22120.09\u00b10.35D in groups A and B, respectively (p=0.13). 39.6% of children in group B had no axial elongation over 12 months compared with 12.2% of the children in group A (p=0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combination treatment with 0.025% atropine and DIMS spectacle lenses is more effective in controlling axial elongation than 0.025% atropine with SV lenses. Although not significant, SER differences between groups were lower in group B. These findings support a potential additive effect of the two treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2024-326852","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T13:20:16Z","timestamp":1746796816000},"page":"1074-1080","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Atropine and Spectacle lens Combination Treatment (ASPECT): 12-month results of a randomised controlled trial for myopia control using a combination of Defocus Incorporated Multiple Segments (DIMS) lenses and 0.025% atropine"],"prefix":"10.1136","volume":"109","clinical-trial-number":[{"clinical-trial-number":"nct06431841","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-1212","authenticated-orcid":false,"given":"Noemi","family":"Guemes-Villahoz","sequence":"first","affiliation":[{"name":"Opthalmology Service, Hospital 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-718X","authenticated-orcid":false,"given":"Rafael","family":"Bella-Gala","sequence":"additional","affiliation":[{"name":"Optometry and Vision, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-5914","authenticated-orcid":false,"given":"Alicia","family":"Ruiz-Pomeda","sequence":"additional","affiliation":[{"name":"Optometry and Vision, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-315X","authenticated-orcid":false,"given":"Beatriz","family":"Martin-Garcia","sequence":"additional","affiliation":[{"name":"Optometry and Vision, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-7294","authenticated-orcid":false,"given":"Elena","family":"Hernandez-Garcia","sequence":"additional","affiliation":[{"name":"Opthalmology Service, Hospital Cl\u00ednico Universitario San Carlos, Madrid, Spain"},{"name":"Ophthalmology, The Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8341-1599","authenticated-orcid":false,"given":"Nunila","family":"Gomez de Lia\u00f1o","sequence":"additional","affiliation":[{"name":"Optometry and Vision, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-0936","authenticated-orcid":false,"given":"Rakhee","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Optometry and Visual Sciences, City St 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