{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:53:47Z","timestamp":1776210827278,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"8","funder":[{"name":"NIH\/NCI","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,2,17]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                  <jats:title>Background\/aims<\/jats:title>\n                  <jats:p>Sebaceous carcinoma (SC) is a rare cancer with periocular predilection. Studies focused on patterns and timing of nodal metastasis are scarce.<\/jats:p>\n                  <jats:p>Our aim is to report patterns of regional nodal metastasis in patients with eyelid SC, including results of sentinel lymph node biopsy (SLNB).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All consecutive patients with eyelid SC treated during 1999\u20132023 were retrospectively reviewed.<\/jats:p>\n                  <jats:p>All subjects had standard of care surgery for eyelid SC and regional lymph node evaluation using physical examination and ultrasonography (US) at baseline and during the surveillance period. 38 patients with negative findings on US had SLNB to rule out microscopic metastasis.<\/jats:p>\n                  <jats:p>The frequency and timing of lymph node metastasis, the SLNB positivity rate, management of nodal metastasis, overall and disease-specific survival were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 138 patients were included. 30 patients (22%) had lymph node metastasis: 15 patients were diagnosed at the time of initial diagnosis of eyelid SC; 18 patients developed nodal metastasis during the follow-up period, at a median of 12 months (range, 1\u2013132). Of 38 patients, 5 (13%) had a positive SLNB. Management of nodal metastasis entailed surgical resection of the involved nodal basins in 27 patients; 20 had adjuvant radiotherapy and 7 had adjuvant concurrent chemoradiation. In patients with nodal metastasis, the 2-year and 5-year disease-specific survival rates were 87.5% and 75.4%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>One-half of the patients with eyelid SC with nodal metastasis had negative findings at initial presentation but developed nodal metastasis during follow-up, highlighting the importance of continued lymph node surveillance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2024-326923","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:25:14Z","timestamp":1740529514000},"page":"903-908","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Timing of nodal metastasis in patients with eyelid sebaceous carcinoma and implications for surveillance and survival"],"prefix":"10.1136","volume":"109","author":[{"given":"Tracy","family":"Lu","sequence":"first","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Anthony","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"},{"name":"Department of Ophthalmology, Brooke Army Medical Center, Fort Sam Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Goepfert","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-1821","authenticated-orcid":false,"given":"Bita","family":"Esmaeli","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"2025100901550816000_109.8.903.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00796-5"},{"key":"2025100901550816000_109.8.903.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312635"},{"key":"2025100901550816000_109.8.903.3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22009"},{"key":"2025100901550816000_109.8.903.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.07.031"},{"key":"2025100901550816000_109.8.903.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.9.1049"},{"key":"2025100901550816000_109.8.903.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.11.006"},{"key":"2025100901550816000_109.8.903.7","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S162073"},{"key":"2025100901550816000_109.8.903.8","doi-asserted-by":"publisher","DOI":"10.3109\/01676830.2011.648799"},{"key":"2025100901550816000_109.8.903.9","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.8.820"},{"key":"2025100901550816000_109.8.903.10","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181ef7450"},{"key":"2025100901550816000_109.8.903.11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30673-4"},{"key":"2025100901550816000_109.8.903.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.07.015"},{"key":"2025100901550816000_109.8.903.13","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17045"},{"key":"2025100901550816000_109.8.903.14","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003847"},{"key":"2025100901550816000_109.8.903.15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303758"},{"key":"2025100901550816000_109.8.903.16","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-016-0187-6"},{"key":"2025100901550816000_109.8.903.17","unstructured":"Amin MB , Edge SB , Greene FL , et al , eds. AJCC cancer staging manual. 8th edn. New York, NY: Springer, 2017."},{"key":"2025100901550816000_109.8.903.18","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1475874","article-title":"High expression of PD-1 and PD-L1 in ocular adnexal sebaceous carcinoma","volume":"7","author":"Kandl","year":"2018","journal-title":"Oncoimmunology"},{"key":"2025100901550816000_109.8.903.19","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001164"},{"key":"2025100901550816000_109.8.903.20","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0357-3"},{"key":"2025100901550816000_109.8.903.21","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.1111\/ajd.13919","article-title":"Combination treatment of bilateral periocular sebaceous carcinomas with microsatellite instability with neoadjuvant pembrolizumab and Mohs surgery","volume":"63","author":"Woods","year":"2022","journal-title":"Australas J Dermatol"},{"key":"2025100901550816000_109.8.903.22","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14770"},{"key":"2025100901550816000_109.8.903.23","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2310"},{"key":"2025100901550816000_109.8.903.24","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1688"},{"key":"2025100901550816000_109.8.903.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0454-y"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2024-326923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:56:22Z","timestamp":1760000182000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2024-326923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,7,22]]},"published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1136\/bjo-2024-326923"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2024-326923","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}