{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:33:57Z","timestamp":1784601237380,"version":"3.55.0"},"reference-count":34,"publisher":"BMJ","issue":"9","funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["VGH V112C-069"],"award-info":[{"award-number":["VGH V112C-069"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,4,11]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cataract surgery has been shown to reduce the risk of developing dementia in the future; however, its impact on different dementia subtypes, including vascular dementia, remains unknown. Moreover, its dementia-protecting effect among cataract patients with common mental disorder (CMD) remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients aged 65 or older diagnosed with cataract between 2012 and 2021 were included and grouped based on whether they underwent cataract surgery within 1 year of diagnosis. Propensity-score matching was used to balance baseline characteristics, and Cox proportional hazards models were applied to assess dementia incidence within 5 years post-cataract between groups. Subgroup analyses were performed based on CMD status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After propensity-score matching, 75\u2009757 patients were included in both surgery and control groups. Cataract surgery significantly reduced dementia risk (HR=0.677, 95% CI =0.638 to 0.719, p&lt;0.001), particularly for Alzheimer\u2019s disease (HR=0.643, 95%\u2009CI=0.576 to 0.716, p&lt;0.001), with no significant effect on vascular dementia (HR=0.968, 95%\u2009CI=0.851 to 1.101, p=0.621). Subgroup analyses showed a significant reduction in dementia risk for patients without CMD (HR=0.666, 95%\u2009CI=0.624 to 0.710, p&lt;0.001), but no protective effect in those with CMD, regardless of CMD status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cataract surgery is linked to a lower risk of dementia, especially Alzheimer\u2019s disease, in patients with cataract. However, this protective effect is diminished in those with CMD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2025-327134","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T13:20:21Z","timestamp":1745846421000},"page":"990-996","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of mental health comorbidities on the effect of cataract surgery on dementia risk: a real-world retrospective cohort study"],"prefix":"10.1136","volume":"109","author":[{"given":"Shih-Kai","family":"Kao","sequence":"first","affiliation":[{"name":"Department of General Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Pei","family":"Yueh","sequence":"additional","affiliation":[{"name":"Department of Medical Education, 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