{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:31:50Z","timestamp":1771504310435,"version":"3.50.1"},"reference-count":49,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,8,15]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify risk factors for changes in Bruch\u2019s membrane opening-based optical coherence tomography (OCT) parameters after glaucoma surgery and to evaluate duration and dynamics of structural reversal of disc cupping (SRDC) in three different types of glaucoma surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, interventional case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Evaluation of 151 eyes of 151 patients who received trabeculectomy, ab-interno trabeculotomy or glaucoma drainage device (GDD) surgery. Dynamics of postoperative change in Bruch membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fibre layer thickness in spectral-domain OCT were assessed. Multiple linear regression models identified risk factors for occurrence and magnitude of SRDC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with baseline, BMO-MRW increased significantly up to the 9-month follow-up (p=0.048) after surgery. A multiple regression model for all patients showed a high relative reduction in intraocular pressure (IOP) (standard \u03b2=\u22120.272, p&lt;0.001), an early date of follow-up (\n                      <jats:italic>stand<\/jats:italic>\n                      \u03b2=\u22120.280, p&lt;0.001) and GDD as surgical procedure (standard \u03b2=0.169, p=0.027) as significant risk factors for SRDC.\n                    <\/jats:p>\n                    <jats:p>\n                      Within the first 9 months after intervention, a low postoperative IOP (standard \u03b2=\u22120.469, p\n                      <jats:italic>&lt;<\/jats:italic>\n                      0.001), a young age (standard \u03b2=\u22120.423, p&lt;0.001) and a short axial length (standard \u03b2=\u22120.235, p\n                      <jats:italic>=<\/jats:italic>\n                      0.040) had a significant impact on the BMO-MRW increase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this set of patients with glaucoma undergoing different types of IOP-lowering surgery, significant SRDC was seen up to 9 months postoperatively. Risk factors for the extent of SRDC were younger age at surgery, early hypotonia or low postoperative IOP and hyperopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327178","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T17:20:14Z","timestamp":1757956814000},"page":"295-303","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for postoperative structural reversal of disc cupping in Bruch membrane opening-based morphometry of the optic nerve head for glaucoma"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-8686","authenticated-orcid":false,"given":"Florian Thomas","family":"Steinberg","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital Cologne Centre of Ophthalmology, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Schiller","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics and Bioinformatics (IMSB), University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-7385","authenticated-orcid":false,"given":"Caroline","family":"Gietzelt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Cologne Centre of Ophthalmology, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kiessling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St Martinus-Krankenhaus, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-7652","authenticated-orcid":false,"given":"Jan Niklas","family":"L\u00fcke","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Cologne Centre of Ophthalmology, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig M","family":"Heindl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Cologne Centre of Ophthalmology, Cologne, Germany"},{"name":"Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Dusseldorf, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S","family":"Dietlein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Cologne Centre of Ophthalmology, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Enders","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Cologne Centre of Ophthalmology, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"2026021903500779000_110.3.295.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300539"},{"key":"2026021903500779000_110.3.295.2","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2020.0225"},{"key":"2026021903500779000_110.3.295.3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1055\/s-0029-1246078","article-title":"Biological and physical aspects of intraocular pressure","volume":"228","author":"Reitsamer","year":"2011","journal-title":"Klin Monbl Augenheilkd"},{"key":"2026021903500779000_110.3.295.4","doi-asserted-by":"crossref","unstructured":"Rosdahl JA . 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