{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T02:35:21Z","timestamp":1769135721220,"version":"3.49.0"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,8,15]]},"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Intravitreal injections (IVIs) are the most common outpatient procedure worldwide, yet no consensus exists regarding their optimal setting. This study analysed 101\u2009976 IVIs performed between 2017 and 2023, comparing endophthalmitis rates before and after introducing a mobile laminar air flow (LAF) device in a clean room. The incidence of endophthalmitis decreased from 0.033% to 0.013%, a 63.2% risk reduction (Odds Ratio=0.368, p=0.04). These findings suggest that mobile LAF enhances air quality and reduces infection risk, offering a cost-effective, efficient alternative to operating theatres for IVIs.<\/jats:p>","DOI":"10.1136\/bjo-2025-327316","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:20:20Z","timestamp":1756315220000},"page":"155-157","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a laminar air flow portable device on post-intravitreal injection endophthalmitis rate"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9010-1208","authenticated-orcid":false,"given":"Matteo","family":"Airaldi","sequence":"first","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"},{"name":"Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK"},{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-1965","authenticated-orcid":false,"given":"Salvatore","family":"Parrulli","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Trinco","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Cinus","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Staurenghi","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Cereda","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Clinical Science \"Luigi Sacco\u201d, Ophthalmology, Luigi Sacco University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"2026012202151211000_110.2.155.1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.oret.2019.03.023","article-title":"Real-World Trends in Intravitreal Injection Practices among American Retina Specialists","volume":"3","author":"Chaturvedi","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"2026012202151211000_110.2.155.2","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1007\/s00417-023-06108-y","article-title":"The ideal intravitreal injection setting: office, ambulatory surgery room or operating theatre? A narrative review and international survey","volume":"261","author":"Veritti","year":"2023","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2026012202151211000_110.2.155.3","doi-asserted-by":"publisher","DOI":"10.1159\/000486145"},{"key":"2026012202151211000_110.2.155.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-016-0236-1"},{"key":"2026012202151211000_110.2.155.5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.oret.2019.03.009","article-title":"International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis: European Vitreo-Retinal Society Endophthalmitis Study Report 1","volume":"3","author":"Soliman","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"2026012202151211000_110.2.155.6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.survophthal.2019.01.009","article-title":"Toxic anterior segment syndrome: A review","volume":"64","author":"Hernandez-Bogantes","year":"2019","journal-title":"Surv Ophthalmol"},{"key":"2026012202151211000_110.2.155.7","doi-asserted-by":"crossref","first-page":"101218","DOI":"10.1016\/j.preteyeres.2023.101218","article-title":"Consensus and controversies in the science of endophthalmitis management: Basic research and clinical perspectives","volume":"97","author":"Das","year":"2023","journal-title":"Prog Retin Eye Res"},{"key":"2026012202151211000_110.2.155.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6334.10"},{"key":"2026012202151211000_110.2.155.9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1001\/jamaophthalmol.2021.3096","article-title":"Safety of Receiving Anti-Vascular Endothelial Growth Factor Intravitreal Injection in Office-Based vs Operating Room Settings: A Meta-analysis","volume":"139","author":"Li","year":"2021","journal-title":"JAMA Ophthalmol"},{"key":"2026012202151211000_110.2.155.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.013"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2025-327316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:15:24Z","timestamp":1769076924000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2025-327316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1,22]]},"published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1136\/bjo-2025-327316"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2025-327316","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}