{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:50:10Z","timestamp":1782121810340,"version":"3.54.5"},"reference-count":23,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Johnson & Johnson Medical Limited","award":["18SM4898"],"award-info":[{"award-number":["18SM4898"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,11,3]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>The aim of this study was to compare tissue reactions and scarring produced by polypropylene (Prolene) versus polyglactin 910 (Vicryl) sutures in eyelid skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>47\u2009patients with entropion were randomised to 6\u20130 Prolene or 6\u20130 Vicryl. Patients underwent everting sutures 1\u2009month prior to definitive surgery involving wedge excision and retractor plication. Only the randomised suture type was used in both procedures. The study suture within the wedge was analysed histologically. Patients were assessed clinically 2\u2009weeks and 6\u2009months following definitive surgery.<\/jats:p>\n                    <jats:p>The primary outcome was histological inflammatory reaction diameter around the suture assessed by a masked histopathologist. Secondary outcomes were clinical scarring assessed using a validated scar grading questionnaire completed by patients and masked assessors and clinical photographs assessed by two masked oculoplastic surgeons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean inflammatory reaction diameter was 0.39\u2009mm for Prolene and 0.56\u2009mm for Vicryl. Median histological grade sum was 32 (IQR 22\u201337) for Prolene and 40 (IQR 27\u201346) for Vicryl. The median number of foreign body giant cells around the suture was 1 (IQR 0\u20133) for Prolene and 4 (IQR 3\u20138) for Vicryl. Only this last result was statistically significant; the lack of significance for other results may be due to the small sample size. One patient developed a clinical granuloma following surgery with Vicryl. There was no significant difference between suture scarring assessed by questionnaire responses or clinical photography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prolene may cause less histological inflammation than Vicryl in eyelid skin but clinical scarring is similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04724512\">NCT04724512<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327724","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:30:20Z","timestamp":1765535420000},"page":"830-835","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective randomised controlled trial to compare tissue reactions and scarring with polypropylene versus polyglactin 910 sutures in periocular skin"],"prefix":"10.1136","volume":"110","clinical-trial-number":[{"clinical-trial-number":"nct04724512","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04724512","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-9639","authenticated-orcid":false,"given":"Tessa","family":"Fayers","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-1007","authenticated-orcid":false,"given":"John S","family":"Vekinis","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-8641","authenticated-orcid":false,"given":"Laura","family":"Ah-Kye","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Parham","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8826-4915","authenticated-orcid":false,"given":"Priscilla","family":"Anketell","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4363-3135","authenticated-orcid":false,"given":"Justin","family":"Weir","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"A\u2019Hern","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-1324","authenticated-orcid":false,"given":"Ben","family":"Parkin","sequence":"additional","affiliation":[{"name":"University Hospitals Dorset NHS Foundation Trust, Poole, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"2026062202151388000_110.7.830.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2005.10.010"},{"key":"2026062202151388000_110.7.830.2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/a-2004-5330","article-title":"Conjunctival Foreign Body Granuloma after Pterygium Excision and Adaptation by Polyglactin Sutures","volume":"240","author":"Gerding","year":"2023","journal-title":"Klin Monbl Augenheilkd"},{"key":"2026062202151388000_110.7.830.3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/01676830.2024.2404678","article-title":"Foreign body suture granuloma in canthal surgery: association with suture type","volume":"44","author":"Yoon","year":"2025","journal-title":"Orbit"},{"key":"2026062202151388000_110.7.830.4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41433-023-02768-6","article-title":"Lateral tarsal strip procedure: comparison of absorbable sutures and non-absorbable polypropylene suture. 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