{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:34Z","timestamp":1790304394318,"version":"4.1.0"},"reference-count":21,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,8,4]]},"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the presenting symptoms, and the overall survival (OS) and disease-specific survival (DSS) in patients with lacrimal gland adenoid cystic carcinoma (LGACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-centre cohort study included all consecutive patients with LGACC treated by the primary author from November 1998 through August 2024. Demographic data, presenting symptoms, the histological subtype of LGACC, type of surgical treatment, adjuvant radiotherapy or chemotherapy, T category at presentation and survival data were reviewed. Correlations between histological subtypes, T-category, type of surgery (eye sparing vs orbital exenteration), and DSS and OS were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>52 patients had a median age of 43.5 years (range: 9\u201371). Pain was the most common symptom but was only present in 17 patients (33%), 26 patients (50%) had orbital exenteration and 25 (48%) had eye-sparing surgery. Eye-sparing surgery was offered to selected patients only since 2007. Overall, 47 patients (90%) had postoperative radiotherapy and 18 patients (35%) developed distant metastasis. At last contact, 14 patients (27%) had died of disease (median follow-up=60 months). The 5-year and 10-year DSS rates for patients who had eye-sparing surgery (87.1% and 76.2%, respectively) were better than for patients who had orbital exenteration (62.3% and 57.5%, respectively, p=0.049). There was a significant difference between the DSS for basaloid (solid) versus non-basaloid histologic subtypes with a worse survival for basaloid histology (p=0.00057).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pain was present in only one-third of patients with LGACC. The 5-year and 10-year DSS and OS rates are better than previously reported \u2018historic data\u2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327745","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:20:27Z","timestamp":1756315227000},"page":"226-232","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Disease-specific and overall survival for patients with lacrimal gland adenoid cystic carcinoma in recent decades"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-1821","authenticated-orcid":false,"given":"Bita","family":"Esmaeli","sequence":"first","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"},{"name":"Oncologic Ophthalmic Plastic & Orbital Surgery PLLC, HOUSTON, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy J","family":"Lu","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-1066","authenticated-orcid":false,"given":"Hila","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Matthew","family":"Debnam","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Jay","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Ferrarotto","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"2026012202151220000_110.2.226.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02402.x"},{"key":"2026012202151220000_110.2.226.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316142"},{"key":"2026012202151220000_110.2.226.3","unstructured":"Font RL , Gamel JW . Epithelial tumors of the lacrimal gland: an analysis of 265 cases. In: Jakobiec FA , ed. Ocular and adnexal tumors. Birmingham, AL: Aesculapius Pub. Co, 1978: 787\u2013805."},{"key":"2026012202151220000_110.2.226.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.027"},{"key":"2026012202151220000_110.2.226.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.IOP.0000105518.72611.4F"},{"key":"2026012202151220000_110.2.226.6","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/hed.24433","article-title":"Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma","volume":"38","author":"Esmaeli","year":"2016","journal-title":"Head Neck"},{"key":"2026012202151220000_110.2.226.7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/IOP.0000000000000877","article-title":"Long-Term Outcomes of Eye-Sparing Surgery for Adenoid Cystic Carcinoma of Lacrimal Gland","volume":"34","author":"Han","year":"2018","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2026012202151220000_110.2.226.8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ajo.2018.07.024","article-title":"Long-term Outcomes of Globe-Preserving Surgery With Proton Beam Radiation for Adenoid Cystic Carcinoma of the Lacrimal Gland","volume":"195","author":"Wolkow","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"2026012202151220000_110.2.226.9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijrobp.2015.08.008","article-title":"A Multidisciplinary Orbit-Sparing Treatment Approach That Includes Proton Therapy for Epithelial Tumors of the Orbit and Ocular Adnexa","volume":"95","author":"Holliday","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026012202151220000_110.2.226.10","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/IOP.0000000000001106","article-title":"Eye-Preserving Surgery Followed by Adjuvant Radiotherapy for Lacrimal Gland Carcinoma: Outcomes in 37 Patients","volume":"34","author":"Woo","year":"2018","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"2026012202151220000_110.2.226.11","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/hed.26073","article-title":"Outcomes after eye-sparing surgery vs orbital exenteration in patients with lacrimal gland carcinoma","volume":"42","author":"Bonavolont\u00e0","year":"2020","journal-title":"Head Neck"},{"key":"2026012202151220000_110.2.226.12","unstructured":"El-Naggar AK , Chan JKC , Grandis JR , et al . World health organization classification of tumors of head and neck. Lyon: IARC, 2017."},{"key":"2026012202151220000_110.2.226.13","unstructured":"White VA , Esmaeli B , Dutton JJ , et al . Lacrimal gland carcinoma. In: AJCC cancer staging manual. 8th edn. Switzerland: Springer, 2017: 833\u20139."},{"key":"2026012202151220000_110.2.226.14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ajo.2022.03.027","article-title":"Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma: A Long-Term Follow-up Study of a Trimodal Strategy","volume":"240","author":"Tse","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"2026012202151220000_110.2.226.15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/oncolo\/oyad346","article-title":"Neoadjuvant Intra-arterial Cytoreductive Chemotherapy Improves Outcomes in Lacrimal Gland Adenoid Cystic Carcinoma","volume":"29","author":"Costa","year":"2024","journal-title":"Oncologist"},{"key":"2026012202151220000_110.2.226.16","doi-asserted-by":"crossref","DOI":"10.1186\/s12874-021-01308-8","article-title":"IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Med Res Methodol"},{"key":"2026012202151220000_110.2.226.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.03.030"},{"key":"2026012202151220000_110.2.226.18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0046-8177(82)80180-9","article-title":"Adenoid cystic carcinoma of the lacrimal gland: the clinical significance of a basaloid histologic pattern","volume":"13","author":"Gamel","year":"1982","journal-title":"Hum Pathol"},{"key":"2026012202151220000_110.2.226.19","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197807)42:1<265::AID-CNCR2820420141>3.0.CO;2-Z"},{"key":"2026012202151220000_110.2.226.20","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.76.7.401"},{"key":"2026012202151220000_110.2.226.21","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.3.4"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2025-327745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:15:57Z","timestamp":1769076957000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2025-327745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1,22]]},"published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1136\/bjo-2025-327745"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2025-327745","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}