{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:34:05Z","timestamp":1781620445091,"version":"3.54.5"},"reference-count":34,"publisher":"BMJ","issue":"4","funder":[{"name":"Key R&D Program of China","award":["2024YFC2510800"],"award-info":[{"award-number":["2024YFC2510800"]}]},{"name":"Key R&D Program of China","award":["2024YFC2510801"],"award-info":[{"award-number":["2024YFC2510801"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,10,7]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Aims<\/jats:title>\n The impact of genetic variants on high myopia (HM) remains unclear. This study aims to systematically evaluate the relationship between genetic polymorphisms and HM.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Eligible studies were retrieved from five databases (PubMed, Web of Science, Cochrane, Embase and Scopus) up to 18 January 2025. We included all case-control studies that examined the association of single nucleotide polymorphisms (SNPs) with HM susceptibility. Fixed or random effects models were used to evaluate pooled ORs and CIs for each SNP in HM. Sensitivity analyses were conducted to assess the reliability and stability of the results.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy-six studies (89 separate cohorts) were eligible for the meta-analysis of HM, involving 77 SNPs in 34 genes. Twenty-two SNPs in 13 genes (rs1516794 in\n ACAN<\/jats:italic>\n gene; rs2269336 in\n COL1A1<\/jats:italic>\n gene; rs2071861 and rs2009066 in\n CRYBA4<\/jats:italic>\n gene; rs339501 in\n FGF10<\/jats:italic>\n gene; rs698047 in\n HIVEP3<\/jats:italic>\n gene; rs3741834, rs2300588, rs3759223 and rs7135740 in\n LUM<\/jats:italic>\n gene; rs9318086 in\n MIPEP<\/jats:italic>\n gene; rs243845 and rs1861320 in\n MMP2<\/jats:italic>\n gene; rs662702 and rs644242 in\n PAX6<\/jats:italic>\n gene; rs8027411 and rs17175798 in\n RASGRF1<\/jats:italic>\n gene; rs7839488, rs4395927 and rs6469937 in\n SNTB1<\/jats:italic>\n gene; rs1800470 in\n TGF\u03b21<\/jats:italic>\n gene; and rs7829127 in\n ZMAT4<\/jats:italic>\n gene) showed significant associations with HM.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study identified 22 SNPs in 13 genes (\n ACAN<\/jats:italic>\n ,\n COL1A1<\/jats:italic>\n ,\n CRYBA4<\/jats:italic>\n ,\n FGF10<\/jats:italic>\n ,\n HIVEP3<\/jats:italic>\n ,\n LUM<\/jats:italic>\n ,\n MIPEP<\/jats:italic>\n ,\n MMP2<\/jats:italic>\n ,\n PAX6<\/jats:italic>\n ,\n RASGRF1<\/jats:italic>\n ,\n SNTB1<\/jats:italic>\n ,\n TGF\u03b21<\/jats:italic>\n and\n ZMAT4<\/jats:italic>\n ) as potential genetic biomarkers for HM. Future research should conduct large-scale genome-wide association studies across diverse populations to yield more robust evidence.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bjo-2025-327791","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:25:10Z","timestamp":1761639910000},"page":"470-476","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic associations of high myopia"],"prefix":"10.1136","volume":"110","author":[{"given":"Bin","family":"Mao","sequence":"first","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-4833","authenticated-orcid":false,"given":"Xing-Xuan","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yi","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-4308","authenticated-orcid":false,"given":"Dan-Lin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-8346","authenticated-orcid":false,"given":"Qiao","family":"Fan","sequence":"additional","affiliation":[{"name":"Center for Quantitative Medicine, Duke-NUS Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-4613","authenticated-orcid":false,"given":"Chen-Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2026032002151700000_110.4.470.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"2026032002151700000_110.4.470.2","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.61.4.49","article-title":"The Complications of Myopia: A Review and Meta-Analysis","volume":"61","author":"Haarman","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2026032002151700000_110.4.470.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.010"},{"key":"2026032002151700000_110.4.470.4","doi-asserted-by":"crossref","first-page":"1146291","DOI":"10.3389\/fmed.2023.1146291","article-title":"Influencing factors associated with high myopia in Chinese college students","volume":"10","author":"Zhang","year":"2023","journal-title":"Front Med"},{"key":"2026032002151700000_110.4.470.5","first-page":"588","article-title":"Association and interaction of myopia with SNP markers rs13382811 and rs6469937 at ZFHX1B and SNTB1 in Han Chinese and European populations","volume":"23","author":"Li","year":"2017","journal-title":"Mol Vis"},{"key":"2026032002151700000_110.4.470.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"2026032002151700000_110.4.470.7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1167\/iovs.18-25922","article-title":"Association of Gene Polymorphisms With Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis","volume":"60","author":"Chen","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2026032002151700000_110.4.470.8","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"2026032002151700000_110.4.470.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"2026032002151700000_110.4.470.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.08.009"},{"key":"2026032002151700000_110.4.470.11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1089\/gtmb.2013.0479","article-title":"Evaluation of MYOC, ACAN, HGF, and MET as candidate genes for high myopia in a Han Chinese population","volume":"18","author":"Yang","year":"2014","journal-title":"Genet Test Mol Biomarkers"},{"key":"2026032002151700000_110.4.470.12","unstructured":"Zorn M , Hernandez M , Norton T , et al . 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