{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:04:35Z","timestamp":1776852275117,"version":"3.51.2"},"reference-count":29,"publisher":"BMJ","issue":"5","funder":[{"name":"Program of Shanghai Academic\/Technology Research Leader under the Science and Technology Innovation Action Plan","award":["21XD1402700"],"award-info":[{"award-number":["21XD1402700"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471109"],"award-info":[{"award-number":["82471109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171100"],"award-info":[{"award-number":["82171100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201246"],"award-info":[{"award-number":["82201246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,10,26]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>To identify sociodemographic and clinical factors associated with best-corrected visual acuity (BCVA) restoration at the visit after lost to follow-up (LTFU) in patients with myopic choroidal neovascularization (mCNV) treated with antivascular endothelial growth factor intravitreal injections (IVI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicentre, retrospective cohort study was conducted in China of mCNV patients receiving injections who were LTFU &gt;6 months. Data were collected from baseline visit, pre-LTFU, initial post-LTFU visit and 6 months post-LTFU, and the final visit. Logistic regression analyses assessed associations between sociodemographic\/clinical factors and BCVA restoration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 1155 LTFU patients with mCNV (mean (SD) age: 54 (16) years; 61.6% female), with 66.6% achieving BCVA restoration at the initial post-LTFU visit after LTFU (mean(SD) duration: 315 (154) days. Patients with BCVA restoration were younger (p=0.004), more often from eastern China (p=0.022), and had shorter LTFU duration (p=0.013). Stratification by pre-LTFU BCVA showed that patients with BCVA \u226520\/40 had lower restoration odds (OR 0.65, 95%\u2009CI 0.44 to 0.96; p=0.032) compared with those with BCVA &lt;20\/200. BCVA decline was associated with increased central subfield thickness(CST) (OR 1.52, 95%\u2009CI 1.15 to 2.01; p=0.004). Among 223 patients with \u22656\u2009months post-LTFU, those with initial post-LTFU CST &gt;280\u2009\u00b5m had higher BCVA restoration odds (OR 1.98, 95%\u2009CI 1.02 to 3.92; p=0.046).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Better pre-LTFU BCVA (\u226520\/40) increased post-LTFU deterioration risk (associated with progressive CST thickening), while elevated post-LTFU CST (&gt;280\u2009\u00b5m) predicted higher BCVA restoration odds in patients with sustained follow-up, supporting CST-guided monitoring and early intervention for high-risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327796","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T18:20:19Z","timestamp":1762885219000},"page":"576-585","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and visual recovery in lost-to-follow-up myopic choroidal neovascularization treated with antivascular endothelial growth factor therapy"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-7003","authenticated-orcid":false,"given":"Yupeng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-711X","authenticated-orcid":false,"given":"Yinchen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-911X","authenticated-orcid":false,"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Scientific Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3177-2860","authenticated-orcid":false,"given":"Chuandi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-2797","authenticated-orcid":false,"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-0458","authenticated-orcid":false,"given":"Xiaolu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6504-2467","authenticated-orcid":false,"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-0190","authenticated-orcid":false,"given":"Dawei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital & Clinical Medical School, Lanzhou University; Gansu Clinical Research Center for Eye Diseases, Lanzhou, Gansu, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-1381","authenticated-orcid":false,"given":"Suyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Xuzhou Eye Disease Prevention and Treatment Institute, Xuzhou, Jiangsu, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-593X","authenticated-orcid":false,"given":"Hongbin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-346X","authenticated-orcid":false,"given":"Honghua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of ophthalmology, Guangdong Eye Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongming","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhui","family":"Yu","sequence":"additional","affiliation":[{"name":"Eye Hospital, the First Affiliated Hospital of Harbin Medical University; Key laboratory of basic and clinical research of Heilongjiang Province, Harbin, Heilongjiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Southwest Hospital\/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongtong","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Fourth People's Hospital of Shenyang, Shenyang Eye Research Institute, Key Laboratory of Ophthalmology of Liaoning, Shenyang, Liaoning, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongdi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the Second Affiliated Hospital of Army Medical University, Chongqing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-7357","authenticated-orcid":false,"given":"Zhipeng","family":"You","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Province Key Laboratory of Ophthalmology and Vision Sciences, Jiangxi clinical research center for ophthalmic disease, Jiangxi Provincial Key Laboratory of Vitreoretinal Diseases for Health, Nanchang, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7432-9729","authenticated-orcid":false,"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, TongRen Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General Hospital of Central Theater Command, Wuhan, Hubei, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-0945","authenticated-orcid":false,"given":"Xiaodong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8435-0240","authenticated-orcid":false,"given":"Zhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of 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of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"2026042202150752000_110.5.576.1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ophtha.2017.02.018","article-title":"Treatment Patterns for Myopic Choroidal Neovascularization in the United States: Analysis of the IRIS Registry","volume":"124","author":"Willis","year":"2017","journal-title":"Ophthalmology"},{"key":"2026042202150752000_110.5.576.2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/ceo.14200","article-title":"Myopic 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