{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:05:19Z","timestamp":1779271519055,"version":"3.51.4"},"reference-count":36,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W03042X\/1"],"award-info":[{"award-number":["MR\/W03042X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,11,1]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>Idiopathic epiretinal membrane (iERM) can affect vision in complex ways, requiring assessment beyond visual acuity. We developed a core outcome set (COS) for patients undergoing surgery for macular pucker secondary to iERMs for use in both clinical practice and clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online modified Delphi technique was used, incorporating literature review, stakeholder workshops and two-round Delphi survey, each followed by a hybrid consensus meeting. Stakeholders, including health professionals and patients rated the importance of each outcome on a 9-point Likert scale (1\u20133, not important; 4\u20136, important; 7\u20139, very important). Outcomes scored as \u2018very important\u2019 by \u226580% of stakeholders were included in the COS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-two outcomes were initially included. Only one outcome reached consensus after the first vote, a further 10 after the second vote and five in the final vote. After discussion and considering clinical relevance and patient importance, the initial list of 17 outcomes was reduced to 13 core outcomes, grouped into six overarching domains: measured visual function, symptoms, adverse events, functional ability, quality of life and other, including objective measurements of anatomical findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A minimum COS for iERMS comprising 13 outcomes covering six domains was generated by the modified Delphi process. The COS is not yet ready for use as the methods of assessment and the time points remain to be determined before it can be used in practice. Future research will test the implementation of the COS in clinical practice and its\u2019 potential incorporation into future trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327811","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:45:17Z","timestamp":1765269917000},"page":"651-657","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a core outcome set for patients with epiretinal membranes: a Delphi consensus study"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-7159","authenticated-orcid":false,"given":"Teresa","family":"Sandinha","sequence":"first","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK"},{"name":"St. Paul\u2019s Eye Department, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-4459","authenticated-orcid":false,"given":"Jignasa","family":"Mehta","sequence":"additional","affiliation":[{"name":"School of Allied Health Professions and Nursing, Institute of Population Health, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-0706","authenticated-orcid":false,"given":"Kodchawan","family":"Doungsong","sequence":"additional","affiliation":[{"name":"CHEME, Bangor University, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-5730","authenticated-orcid":false,"given":"Rhiannon Tudor","family":"Edwards","sequence":"additional","affiliation":[{"name":"CHEME, Bangor University, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-3089","authenticated-orcid":false,"given":"David H W","family":"Steel","sequence":"additional","affiliation":[{"name":"Sunderland Eye Infirmary, Newcastle, UK"},{"name":"Biosciences Institute, Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-9378","authenticated-orcid":false,"given":"Deirdre A","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"2026052002050974000_110.6.651.1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2017-000076","article-title":"Monocular and binocular visual impairment in the UK Biobank study: prevalence, associations and diagnoses","volume":"3","author":"McKibbin","year":"2018","journal-title":"BMJ Open Ophthalmol"},{"key":"2026052002050974000_110.6.651.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.175109"},{"key":"2026052002050974000_110.6.651.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-0980-1"},{"key":"2026052002050974000_110.6.651.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.10.014"},{"key":"2026052002050974000_110.6.651.5","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/eye.2013.12","article-title":"United Kingdom National Ophthalmology Database Study of Vitreoretinal Surgery: report 1; case mix, complications, and cataract","volume":"27","author":"Jackson","year":"2013","journal-title":"Eye (Lond)"},{"key":"2026052002050974000_110.6.651.6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2147\/OPTH.S97722","article-title":"Epiretinal membrane: optical coherence tomography-based diagnosis and classification","volume":"10","author":"Stevenson","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"2026052002050974000_110.6.651.7","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1097\/IAE.0000000000000558","article-title":"SURGICAL OUTCOMES IN PATIENTS WITH MACULAR PUCKER AND GOOD PREOPERATIVE VISUAL ACUITY AFTER VITRECTOMY WITH MEMBRANE PEELING","volume":"35","author":"Reilly","year":"2015","journal-title":"Retina"},{"key":"2026052002050974000_110.6.651.8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3109\/02713683.2015.1114654","article-title":"25-Gauge Vitrectomy with Epiretinal Membrane and Internal Limiting Membrane Peeling in Eyes with Very Good Visual Acuity","volume":"41","author":"Moisseiev","year":"2016","journal-title":"Curr Eye Res"},{"key":"2026052002050974000_110.6.651.9","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200510000-00010"},{"key":"2026052002050974000_110.6.651.10","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/eye.2013.305","article-title":"Early surgery for epiretinal membrane preserves more vision for patients","volume":"28","author":"Rahman","year":"2014","journal-title":"Eye (Lond)"},{"key":"2026052002050974000_110.6.651.11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000328398","article-title":"Outcomes of epiretinal membrane removal in eyes with and without concurrent vision-limiting ocular disease","volume":"226","author":"Moisseiev","year":"2011","journal-title":"Ophthalmologica"},{"key":"2026052002050974000_110.6.651.12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41433-021-01681-0","article-title":"Idiopathic epiretinal membrane: progression and timing of surgery","volume":"36","author":"Chua","year":"2022","journal-title":"Eye (Lond)"},{"key":"2026052002050974000_110.6.651.13","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S162802"},{"key":"2026052002050974000_110.6.651.14","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1586\/14737167.6.6.691","article-title":"Assessment of vision-related quality of life measures in ophthalmic conditions","volume":"6","author":"Lundstr\u00f6m","year":"2006","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"2026052002050974000_110.6.651.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)95017-5"},{"key":"2026052002050974000_110.6.651.16","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.ophtha.2021.01.022","article-title":"Development of a Core Outcome Set for Clinical Trials in Non-infectious Uveitis of the Posterior Segment","volume":"128","author":"Tallouzi","year":"2021","journal-title":"Ophthalmology"},{"key":"2026052002050974000_110.6.651.17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2016.04.012","article-title":"Defining a Minimum Set of Standardized Patient-centered Outcome Measures for Macular Degeneration","volume":"168","author":"Rodrigues","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"2026052002050974000_110.6.651.18","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jamaophthalmol.2015.2810","article-title":"A Proposed Minimum Standard Set of Outcome Measures for Cataract Surgery","volume":"133","author":"Mahmud","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"2026052002050974000_110.6.651.19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/IJG.0000000000000301","article-title":"Consensus on Outcome Measures for Glaucoma Effectiveness Trials: Results From a Delphi and Nominal Group Technique Approaches","volume":"25","author":"Ismail","year":"2016","journal-title":"J Glaucoma"},{"key":"2026052002050974000_110.6.651.20","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2020-000481","article-title":"Outcomes important to patients with non-infectious posterior segment-involving uveitis: a qualitative study","volume":"5","author":"Tallouzi","year":"2020","journal-title":"BMJ Open Ophthalmol"},{"key":"2026052002050974000_110.6.651.21","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-042403","article-title":"Core outcome set for three ophthalmic conditions: a healthcare professional and patient consensus on core outcome sets for amblyopia, ocular motility and strabismus (COSAMS Study)","volume":"11","author":"Al-Jabri","year":"2021","journal-title":"BMJ Open"},{"key":"2026052002050974000_110.6.651.22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209869","article-title":"Choosing important health outcomes for comparative effectiveness research: 4th annual update to a systematic review of core outcome sets for research","volume":"13","author":"Gargon","year":"2018","journal-title":"PLoS ONE"},{"key":"2026052002050974000_110.6.651.23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002447","article-title":"Core Outcome Set-STAndards for Development: The COS-STAD recommendations","volume":"14","author":"Kirkham","year":"2017","journal-title":"PLoS Med"},{"key":"2026052002050974000_110.6.651.24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004326","article-title":"ACCORD (ACcurate COnsensus Reporting Document): A reporting guideline for consensus methods in biomedicine developed via a modified Delphi","volume":"21","author":"Gattrell","year":"2024","journal-title":"PLoS Med"},{"key":"2026052002050974000_110.6.651.25","doi-asserted-by":"crossref","DOI":"10.1186\/s12874-019-0886-6","article-title":"A modified Delphi study to identify the features of high quality measurement plans for healthcare improvement projects","volume":"20","author":"Woodcock","year":"2020","journal-title":"BMC Med Res Methodol"},{"key":"2026052002050974000_110.6.651.26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41433-022-02073-8","article-title":"Patient-reported outcome measures in vitreoretinal surgery: a systematic review","volume":"37","author":"Yoganathan","year":"2023","journal-title":"Eye (Lond)"},{"key":"2026052002050974000_110.6.651.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.08.005"},{"key":"2026052002050974000_110.6.651.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.012"},{"key":"2026052002050974000_110.6.651.29","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315432"},{"key":"2026052002050974000_110.6.651.30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-056792","article-title":"Development of core outcome sets and core outcome measures for central visual impairment, visual field loss and ocular motility disorders due to stroke: a Delphi and consensus study","volume":"12","author":"Rowe","year":"2022","journal-title":"BMJ Open"},{"key":"2026052002050974000_110.6.651.31","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/acr.21674","article-title":"Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood","volume":"64","author":"Heiligenhaus","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026052002050974000_110.6.651.32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jclinepi.2021.04.019","article-title":"More than half of systematic reviews have relevant core outcome sets","volume":"136","author":"Saldanha","year":"2021","journal-title":"J Clin Epidemiol"},{"key":"2026052002050974000_110.6.651.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2022.06.016"},{"key":"2026052002050974000_110.6.651.34","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.7.1050"},{"key":"2026052002050974000_110.6.651.35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41433-018-0230-0","article-title":"Patient-reported prevalence of metamorphopsia and predictors of vision-related quality of life in vitreomacular traction: a prospective, multi-centre study","volume":"33","author":"Patel","year":"2019","journal-title":"Eye (Lond)"},{"key":"2026052002050974000_110.6.651.36","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2022-000284","article-title":"Core outcome sets in medical research","volume":"1","author":"Kirkham","year":"2022","journal-title":"BMJ Med"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2025-327811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:05:21Z","timestamp":1779267921000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2025-327811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,5,20]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bjo-2025-327811"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2025-327811","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]}}}