{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:28:23Z","timestamp":1787218103662,"version":"build-2736575974"},"reference-count":20,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,11,22]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>To evaluate retinal microvascular changes using optical coherence tomography angiography (OCTA) and their prognostic value in patients undergoing transsphenoidal surgery for pituitary adenoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study of 90 patients, we assessed best-corrected visual acuity (BCVA), mean deviation (MD) on visual field (VF), and OCTA parameters at the macular region and peripapillary area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with severe VF defects (VFD; MD &lt;\u201310\u2009dB) showed greater reductions in vessel densities of superficial capillary plexus (SCP) and radial peripapillary capillaries (RPC) than those with minimal VFD (MD &gt;\u20133\u2009dB) (p=0.021, 0.047). Higher SCP density, RPC density, peripapillary retinal nerve fibre layer (pRNFL) thickness and ganglion cell complex (GCC) thickness were associated with better postoperative visual acuity (r=\u22120.33, \u20130.44, \u22120.24, \u20130.30; all p&lt;0.05) and MD (r=0.26, 0.46, 0.45, 0.45; all p&lt;0.05). In patients with mild to moderate VFD (MD between \u22123 and \u221210\u2009dB), foveal avascular zone area, foveal SCP and deep capillary plexus densities correlated strongly with BCVA outcome (r=0.61,\u20130.60, \u22120.63; all p&lt;0.01). Area under the curves for predicting &gt;50%\u2009MD improvement were 0.816 (SCP density), 0.784 (RPC density), 0.887 (pRNFL thickness), 0.816 (GCC thickness) and 0.905 (combined; all p\u22640.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After decompression surgery, retinal vessel densities may further decline at 3 months postoperatively, particularly in patients with severe baseline VFD. Foveal parameters predicted visual acuity in those with mild to moderate VFD, while in severe cases, higher SCP density, RPC density, pRNFL thickness and GCC thickness may serve as prognostic biomarkers for predicting better VF improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327846","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T18:25:17Z","timestamp":1772475917000},"page":"1076-1082","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Optical coherence tomography angiography reveals microvascular changes and predicts visual outcomes after decompression surgery for pituitary adenoma"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-7056","authenticated-orcid":false,"given":"Ivan Pochou","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan"},{"name":"Department of Ophthalmology, Fu Jen Catholic University, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel Po-Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Chih","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar-Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Mu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Che","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, National Taiwan University College of Medicine, Taipei City, Taiwan"},{"name":"Department of Traumatology, National Taiwan University College of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5766-3057","authenticated-orcid":false,"given":"Chao-Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2026082002151206000_110.9.1076.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.05.035"},{"key":"2026082002151206000_110.9.1076.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.038489"},{"key":"2026082002151206000_110.9.1076.3","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1111\/aos.14322","article-title":"Retinal microvasculature in pituitary adenoma patients: is optical coherence tomography angiography useful?","volume":"98","author":"Dallorto","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"2026082002151206000_110.9.1076.4","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.ophtha.2016.08.041","article-title":"Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in 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endonasal pituitary surgery: The role of OCT-angiography","volume":"15","author":"Cennamo","year":"2020","journal-title":"PLoS One"},{"key":"2026082002151206000_110.9.1076.9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-59158-1","article-title":"Analysis of Optic Chiasmal Compression Caused by Brain Tumors Using Optical Coherence Tomography Angiography","volume":"10","author":"Lee","year":"2020","journal-title":"Sci Rep"},{"key":"2026082002151206000_110.9.1076.10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40956-2","article-title":"Retinal vascular and structural recovery analysis by optical coherence tomography angiography after endoscopic decompression in sellar\/parasellar tumors","volume":"13","author":"Ergen","year":"2023","journal-title":"Sci Rep"},{"key":"2026082002151206000_110.9.1076.11","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9030697","article-title":"Parafoveal and Peripapillary Perfusion Predict Visual Field Recovery in Chiasmal Compression due to Pituitary Tumors","volume":"9","author":"Lee","year":"2020","journal-title":"J Clin Med"},{"key":"2026082002151206000_110.9.1076.12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260029","article-title":"The role of OCT- angiography in predicting anatomical and functional recovery after endoscopic endonasal pituitary surgery: A 1-year longitudinal study","volume":"16","author":"Cennamo","year":"2021","journal-title":"PLoS One"},{"key":"2026082002151206000_110.9.1076.13","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316371"},{"key":"2026082002151206000_110.9.1076.14","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.6.3.7","article-title":"Diagnostic Ability and Repeatability of a New Supra-Threshold Glaucoma Screening Program in Standard Automated Perimetry","volume":"6","author":"Takahashi","year":"2017","journal-title":"Transl Vis Sci 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decompression: A preliminary study","volume":"44","author":"Mambour","year":"2021","journal-title":"J Fr Ophtalmol"},{"key":"2026082002151206000_110.9.1076.19","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1127"},{"key":"2026082002151206000_110.9.1076.20","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0327"}],"container-title":["British Journal of 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