{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:52:02Z","timestamp":1782435122044,"version":"3.54.5"},"reference-count":35,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,8,3]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the clinical application of a novel swept-source anterior segment optical coherence tomography angiography (AS-OCTA) system for imaging corneal neovascularisation (CoNV), assessing limbal vasculature and detecting short-term vascular changes following pharmacologic vasoconstriction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross-sectional observational study included 20 eyes: 10 with clinically diagnosed CoNV of various aetiologies and 10 healthy controls. Each eye underwent AS-OCTA imaging using the BMizar 400kHz Full-Range Swept-Source OCT system at baseline and after administration of 10% phenylephrine (PE). FlowArea (mm\n                      <jats:sup>2<\/jats:sup>\n                      ) was automatically calculated across predefined circular regions of interest (ROIs) encompassing the cornea, limbus and episclera. In corneal and limbal ROIs, en face images were segmented into three depth layers: total (epithelium to endothelium), superficial (epithelium to 150 \u00b5m) and deep (150 \u00b5m to endothelium).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CoNV eyes exhibited significantly higher total and deep corneal FlowArea compared with controls (p=0.0002\u2009and p=0.0005, respectively). Post PE, a significant reduction in FlowArea was observed in the total and deep corneal layers of CoNV eyes (p=0.006\u2009and p=0.009, respectively), and in the limbal region of both groups, with significant reductions observed in CoNV and controls (p=0.006\u2009and p=0.003, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This AS-OCTA platform enabled high-resolution, depth-resolved visualization of CoNV and revealed vascular changes following topical vasoconstriction. The extended field of view allowed simultaneous assessment of corneal, limbal and episcleral vasculature within a single scan session, supporting its potential role in both diagnostic evaluation and longitudinal monitoring of anterior segment diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-327973","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T17:20:24Z","timestamp":1755537624000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Advanced imaging of corneal neovascularisation with a novel swept-source AS-OCTA system"],"prefix":"10.1136","volume":"110","author":[{"given":"Luca","family":"Lucchino","sequence":"first","affiliation":[{"name":"Eye Unit, University of Brescia Department of Medical-Surgical Specialties Radiological Sciences and Public Health, Brescia, Lombardy, Italy"},{"name":"Sense Organs, University of Rome La Sapienza, 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