{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:20:36Z","timestamp":1774005636595,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,10,25]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to monitor changes in tear monocyte chemotactic protein-1 (MCP-1) levels following endonasal dacryocystorhinostomy (endo-DCR) and external dacryocystorhinostomy (ext-DCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This study was designed as a prospective, longitudinal study and included 42 eyes in the endo-DCR group and 48 eyes in the ext-DCR group. We monitored changes in tear MCP-1 levels. Tear samples were collected on the day before surgery, the first week, and the first and sixth months after surgery to compare changes in tear MCP-1 levels between and within groups. Surgery time and success rates were also compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean MCP-1 levels at baseline, first and sixth months were similar between the groups (p=0.722, p=0.661, p=0.676, respectively). In the first week, it was significantly higher in the ext-DCR group than in the endo-DCR group (p&lt;0.001). In the endo-DCR group, it showed a significant and continuous decrease until the first month (p&lt;0.001), and the decrease stabilised in the sixth month. In the ext-DCR group, the mean MCP-1 level displayed a significant peak increase during the first week, followed by a steady decline until the sixth month (p&lt;0.001). The surgery time was longer in the ext-DCR group (p&lt;0.001) and showed a significant correlation with MCP-1 levels in the first week (Spearman\u2019s rho=0.857, p &lt;0.001). The groups\u2019 subjective and anatomical success rates were similar (p=0.642, p=0.549, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both surgeries demonstrated comparable success rates and decreased tear MCP-1 levels during follow-up. In the first week, the mean MCP-1 level exhibited a significant peak increase in the ext-DCR group. Extended surgical duration is a recognised factor affecting the wound-healing process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328030","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:10:20Z","timestamp":1762409420000},"page":"464-468","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring tear monocyte chemoattractant protein-1 levels after endonasal versus external dacryocystorhinostomy: a prospective, longitudinal study"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-6402","authenticated-orcid":false,"given":"Sinem","family":"Karabulut","sequence":"first","affiliation":[{"name":"opthalmology, TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Mu\u011fla E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Mugla, Mu\u011fla Province, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-1442","authenticated-orcid":false,"given":"Ercan","family":"Saruhan","sequence":"additional","affiliation":[{"name":"Biochemistry, Mugla Sitki Kocman Universitesi, Mugla, Mu\u011fla Province, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7844-5638","authenticated-orcid":false,"given":"M\u00fcjdat","family":"Karabulut","sequence":"additional","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Mu\u011fla E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Mugla, Mu\u011fla Province, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-5083","authenticated-orcid":false,"given":"Okan","family":"Akmaz","sequence":"additional","affiliation":[{"name":"Izmir Bozyaka Training and Research Hospital, Izmir, \u0130zmir, 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