{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:18:30Z","timestamp":1787681910761,"version":"build-2784847793"},"reference-count":26,"publisher":"BMJ","funder":[{"name":"Science and Technology Innovation Program of Hunan Province","award":["2024RC5002"],"award-info":[{"award-number":["2024RC5002"]}]},{"name":"National Ministry of Science and Techniques, China","award":["2022YFE0124600"],"award-info":[{"award-number":["2022YFE0124600"]}]},{"name":"Science and Technology Innovation Programme of Hunan Province","award":["2023RC1079"],"award-info":[{"award-number":["2023RC1079"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,7,18]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the associations between retinal\/choroidal vascular parameters and macular sensitivity (MS) in adults with myopic macular degeneration (MMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included a total of 439 eyes from 253 participants of the Aier-SERI high myopia cohort in Changsha, central China. MS was evaluated using the microperimetry (MP-3). Retinal and choroidal vascular parameters, including superficial vascular density (SVD), deep vascular density (DVD), choriocapillaris perfusion area (CCPA) and choroidal vascularity index (CVI), were quantified using swept-source optical coherence tomography angiography (SS-OCTA). Differences in MS across MMD severity categories were analysed via one-way analysis of variance, and relationships between retinal\/choroidal vascular parameters and MS were evaluated using multivariable linear regression models with generalised estimating equations to account for inter-eye correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants had an average age of 44.6\u00b16.6 years with a mean spherical equivalent (SE) of \u22129.1\u00b14.1 D and axial length (AL) of 27.2\u00b11.8\u2009mm. MS, SVD, DVD and CVI in different regions decreased with increasing severity of MMD (all\n                      <jats:italic>P<\/jats:italic>\n                      values &lt;0.05), but CCPA not (p&gt;0.05). In multivariate models, factors related to reduced MS included older age (\u03b2=\u22120.074, p=0.007), longer AL (\u03b2=\u22120.388, p&lt;0.001), increasing severity of MMD (\u03b2\u2264\u22120.677, all p&lt;0.05), lower SVD (\u03b2=0.077, p=0.022), lower DVD (\u03b2=0.069, p=0.019) and lower CVI (\u03b2=3.083, p=0.015). CVI demonstrated significantly greater discriminatory power for MS impairment compared with SVD and DVD in different regions (all P values &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced MS is associated with more severe MMD, older age, longer AL, lower SVD, lower DVD and lower CVI. Among retinal\/choroidal vascular biomarkers, CVI exhibits superior diagnostic utility for identifying MS impairment in MMD, highlighting the choroid\u2019s potential role as a sensitive indicator of visual function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328323","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:20:16Z","timestamp":1787678416000},"page":"bjo-2025-328323","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association between retinal\/choroidal vascularity and macular sensitivity in myopic macular degeneration: Aier-SERI high myopia adult cohort study"],"prefix":"10.1136","author":[{"given":"Yanfeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Aier Academy of Ophthalmology, Central South University, No. 188, Furong South Road, Tianxin District, Changsha, 410004, Hunan, PR China, changsha, China"},{"name":"Changsha Aier 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