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After vitamin A supplementation, mean visual acuity improved from 0.2 to 0.1 logMAR, and the initially observed ellipsoid and interdigitation zone abnormalities on OCT imaging improved, supporting previous reports. In contrast, we describe a lack of normal foveal hypoautofluorescence on FAF imaging, which persisted post-treatment and could also be a useful diagnostic sign.<\/jats:p>","DOI":"10.1136\/bjo-2025-328384","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:20:19Z","timestamp":1763058019000},"page":"658-660","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced macular pigment in vitamin A deficiency retinopathy"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9349-4043","authenticated-orcid":false,"given":"Christina","family":"Karakosta","sequence":"first","affiliation":[{"name":"Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-2112","authenticated-orcid":false,"given":"Johannes","family":"Birtel","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"},{"name":"Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Charbel Issa","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"},{"name":"Department of Ophthalmology, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha Roshani","family":"De Silva","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"},{"name":"Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2026052002050976000_110.6.658.1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.oret.2023.08.021","article-title":"Characteristics of Vitamin A Deficiency Retinopathy at a Tertiary Referral Center in the United States","volume":"8","author":"Levine","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"2026052002050976000_110.6.658.2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031014","article-title":"The Role of Vitamin A in Retinal Diseases","volume":"23","author":"Sajovic","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026052002050976000_110.6.658.3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-65763-x","article-title":"Short-Wavelength and Near-Infrared Autofluorescence in Patients with Deficiencies of the Visual Cycle and Phototransduction","volume":"10","author":"Oh","year":"2020","journal-title":"Sci Rep"},{"key":"2026052002050976000_110.6.658.4","doi-asserted-by":"crossref","unstructured":"Berkenstock MK , Castoro CJ , Carey AR . 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