{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:08:06Z","timestamp":1779127686731,"version":"3.51.4"},"reference-count":42,"publisher":"BMJ","funder":[{"name":"IITP","award":["IITP-2026-RS-2024-00438239"],"award-info":[{"award-number":["IITP-2026-RS-2024-00438239"]}]},{"name":"Global Physician-scientist program funded by the Ministry of Health and Welfare of Korea","award":["RS-2024-00405141"],"award-info":[{"award-number":["RS-2024-00405141"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2025-02220492"],"award-info":[{"award-number":["RS-2025-02220492"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00248157"],"award-info":[{"award-number":["RS-2023-00248157"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00441114"],"award-info":[{"award-number":["RS-2024-00441114"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although health problems may persist beyond 4\u2009weeks after SARS-CoV-2 infection, evidence on long-term ophthalmic sequelae is limited. We conducted a binational, population-based cohort study to evaluate the association between postacute sequelae of SARS-CoV-2 infection and the risk of multiple ophthalmic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from two large cohorts: South Korea (discovery cohort; n=15,992,761) and Japan (validation cohort; n=12,218,680), including individuals aged \u226520 years who were infected with SARS-CoV-2. Cox proportional hazards models with propensity score-based overlap weighting were used to estimate HRs, with analyses stratified by COVID-19 severity and SARS-CoV-2 variant period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the overlap-weighted discovery cohort, 4\u2009041\u2009250 individuals (mean age 52.52 years (SD 11.52); 59.1% male) were included. SARS-CoV-2 infection was associated with a long-term increased risk of any ophthalmic disease (HR, 1.23 (95% CI, 1.22\u20131.25)). Elevated risks were observed for glaucoma (1.21 (1.19\u20131.23)), cornea and conjunctiva diseases (1.22 (1.21\u20131.23)), blepharitis (1.19 (1.17\u20131.22)), retinopathy (1.17 (1.15\u20131.18)), uveitis (1.11 (1.01\u20131.22)) and neuro-ophthalmic diseases (1.11 (1.06\u20131.15)). The risk of ophthalmic diseases gradually attenuated over time after SARS-CoV-2 infection. The risk was more pronounced among individuals with severe COVID-19. The associations between SARS-CoV-2 infection and the risk of ophthalmic diseases were generally consistent across the pre-Delta, Delta and Omicron eras. Similar patterns were consistently observed in the validation cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest an increased risk of postacute ophthalmic sequelae following SARS-CoV-2 infection, underscoring the need for sustained clinical vigilance across a broad range of ophthalmic conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328412","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:20:20Z","timestamp":1779124820000},"page":"bjo-2025-328412","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Postacute sequelae of SARS-CoV-2 infection on ophthalmic diseases: a binational cohort study"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-2233","authenticated-orcid":false,"given":"Jee 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