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In multivariable logistic regression analysis, factors with a p value of \u22640.2 in univariate analysis were included in the model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 826 subjects met final inclusion criteria. In multivariable regression analysis adjusted for potential confounders, baseline factors associated with incident glaucoma were: pseudoexfoliation (PEX) (p=0.002); higher intraocular pressure (IOP) (p&lt;0.001); cup-to-disc ratio (p=0.020); family history of glaucoma (p=0.029); history of heart attack (p=0.002), blood pressure (BP) \u2264140\/90 without anti-hypertensive treatment (p=0.019) compared with BP &gt;140\/90. Increased hours of sleep (p=0.043) and alcohol consumption (p=0.030) were found to be protective factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased IOP, PEX, increased vertical c\/d ratio, family history of glaucoma, history of heart attack and BP \u2264140\/90 increased the risk for incident OAG. Increased hours of sleep and alcohol consumption were inversely associated with the development of incident glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328564","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:20:18Z","timestamp":1775668818000},"page":"1171-1176","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline risk factors for the development of open-angle glaucoma in a 12-year glaucoma incidence study: the Thessaloniki Eye Study"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-3765","authenticated-orcid":false,"given":"Panagiota","family":"Ntonti","sequence":"first","affiliation":[{"name":"1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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