{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:50:08Z","timestamp":1782121808532,"version":"3.54.5"},"reference-count":29,"publisher":"BMJ","issue":"7","funder":[{"name":"Shanghai Shenkang Hospital Development Center","award":["SHDC12026129"],"award-info":[{"award-number":["SHDC12026129"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271069, 82371040, 82122017, 81870642, 81970780,"],"award-info":[{"award-number":["82271069, 82371040, 82122017, 81870642, 81970780,"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research and Development Program of China","award":["2022YFC2502800 and 2024YFC2510800"],"award-info":[{"award-number":["2022YFC2502800 and 2024YFC2510800"]}]},{"name":"Shanghai Municipal Health Commission Project","award":["2024ZZ1025"],"award-info":[{"award-number":["2024ZZ1025"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program","award":["20244Z0015"],"award-info":[{"award-number":["20244Z0015"]}]},{"name":"Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission","award":["23Y11909800"],"award-info":[{"award-number":["23Y11909800"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,11,25]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine whether choroidal thickness influences the risk of clinically significant pseudophakic cystoid macular oedema (CME).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective case\u2013control study of non-diabetic adults who underwent uncomplicated cataract surgery at the Eye &amp; ENT Hospital of Fudan University between June 2023 and December 2024. Electronic records were reviewed to estimate pseudophakic CME incidence. For each CME case diagnosed, age-matched and sex-matched patients without CME within 3 months postoperatively were randomly selected as controls. Potential ocular risk factors, including axial length (AL), central retinal thickness, subfoveal choroidal thickness (SFCT), posterior vitreous detachment (PVD) and others, were assessed with multivariable logistic regression. Treatment methods and prognosis of CME cases were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 9793 eyes, CME occurred in 65 (0.66%). After age adjustment, eyes with AL &lt;26\u2009mm (age-related cataract, ARC) had higher CME risk than those with AL \u226526\u2009mm (highly myopic catar, HMC) (OR=1.94, p=0.046). Compared with matched controls, CME cases had shorter AL, less PVD and thicker SFCT (all p&lt;0.001). In multivariable analysis, only thicker SFCT remained associated with CME (OR=1.012, p&lt;0.001). SFCT predicted CME with areas under the curve of 0.805 in HMC and 0.792 in ARC. Mean recovery time was 38.7\u00b19.6\u2009days with periocular steroid injection plus topical steroid and non-steroidal anti-inflammatory drugs versus 42.4\u00b112.3\u2009days with topical therapy alone. Cox regression confirmed faster recovery with the combined regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thinner choroidal thickness, which is common in high myopia, acts as a protective factor against pseudophakic CME.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328615","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:20:20Z","timestamp":1765650020000},"page":"817-822","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Choroid thickness: a potential biomarker for pseudophakic cystoid macular oedema"],"prefix":"10.1136","volume":"110","author":[{"given":"Wenwen","family":"He","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongling","family":"Guo","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Hu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-3229","authenticated-orcid":false,"given":"Kaiwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Qi","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Meng","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghia, People's Republic of China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, People's Republic of China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghia, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-8866","authenticated-orcid":false,"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-1667","authenticated-orcid":false,"given":"Xiangjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical 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Tomography Angiography","volume":"2023","author":"Lu","year":"2023","journal-title":"J Ophthalmol"},{"key":"2026062202151376000_110.7.817.18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202930","article-title":"Choroidal vascularity changes in idiopathic central serous chorioretinopathy after half-fluence photodynamic therapy","volume":"13","author":"Ma","year":"2018","journal-title":"PLoS One"},{"key":"2026062202151376000_110.7.817.19","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00417-020-04940-0","article-title":"Pachychoroid: current concepts on clinical features and pathogenesis","volume":"259","author":"Castro-Navarro","year":"2021","journal-title":"Graefes Arch Clin Exp 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