{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:31:25Z","timestamp":1792704685662,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,11,28]]},"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1136\/bjo-2025-328695","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:20:20Z","timestamp":1765304420000},"page":"1306-1311","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of natamycin monotherapy versus combination therapy with voriconazole for fungal keratitis: a randomised clinical trial"],"prefix":"10.1136","volume":"110","clinical-trial-number":[{"clinical-trial-number":"nct03230058","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03230058","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Antonio","family":"Di Zazzo","sequence":"first","affiliation":[{"name":"LVPEI, Hyderabad, Telangana, India"},{"name":"Oftalmologia, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-4694","authenticated-orcid":false,"given":"Pier Luigi","family":"Surico","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, University of Rome La Sapienza, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday Pratap Singh","family":"Parmar","sequence":"additional","affiliation":[{"name":"Mass Eye and Ear, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Tarini","sequence":"additional","affiliation":[{"name":"LVPEI, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"De Luca","sequence":"additional","affiliation":[{"name":"Oftalmologia, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagyasree","family":"Madduri","sequence":"additional","affiliation":[{"name":"Ocular Microbiology Service, L.V. Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Mohan","sequence":"additional","affiliation":[{"name":"Ocular Microbiology Service, L.V. Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-6757","authenticated-orcid":false,"given":"Merle","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Cornea, LVPEI, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"2026102202150873000_110.11.1306.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.8.622"},{"key":"2026102202150873000_110.11.1306.2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0218.120153"},{"key":"2026102202150873000_110.11.1306.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30448-5"},{"key":"2026102202150873000_110.11.1306.4","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200408000-00008"},{"key":"2026102202150873000_110.11.1306.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.10.1235"},{"key":"2026102202150873000_110.11.1306.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.023"},{"key":"2026102202150873000_110.11.1306.7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/jamaophthalmol.2013.1497","article-title":"The Mycotic Ulcer Treatment Trial","volume":"131","author":"Prajna","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"2026102202150873000_110.11.1306.8","doi-asserted-by":"crossref","first-page":"120484","DOI":"10.1016\/j.ijpharm.2021.120484","article-title":"Enhanced in vivo antifungal activity of novel cell penetrating peptide natamycin conjugate for efficient fungal keratitis management","volume":"600","author":"Rohira","year":"2021","journal-title":"Int J Pharm"},{"key":"2026102202150873000_110.11.1306.9","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-013-0150-1"},{"key":"2026102202150873000_110.11.1306.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.063"},{"key":"2026102202150873000_110.11.1306.11","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S6374"},{"key":"2026102202150873000_110.11.1306.12","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2007.8"},{"key":"2026102202150873000_110.11.1306.13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.12669\/pjms.39.3.6908","article-title":"Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis","volume":"39","author":"Cai","year":"2023","journal-title":"Pak J Med Sci"},{"key":"2026102202150873000_110.11.1306.14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/APO.0b013e3182a618dd","article-title":"Effectiveness of Topical Antifungal Drugs in the Management of Fungal Keratitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials","volume":"3","author":"McDonald","year":"2014","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"2026102202150873000_110.11.1306.15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310683"},{"key":"2026102202150873000_110.11.1306.16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/01.ico.0000134193.64357.82","article-title":"Concurrent use of 5% natamycin and 2% econazole for the management of fungal keratitis","volume":"23","author":"Prajna","year":"2004","journal-title":"Cornea"},{"key":"2026102202150873000_110.11.1306.17","doi-asserted-by":"crossref","DOI":"10.1186\/1745-6215-11-32","article-title":"CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials","volume":"11","author":"Schulz","year":"2010","journal-title":"Trials"},{"key":"2026102202150873000_110.11.1306.18","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1001\/jamaophthalmol.2016.4096","article-title":"Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic Ulcer Treatment Trial II (MUTT II): A Randomized Clinical Trial","volume":"134","author":"Prajna","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"2026102202150873000_110.11.1306.19","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv421"},{"key":"2026102202150873000_110.11.1306.20","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306485"},{"key":"2026102202150873000_110.11.1306.21","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/j.ophtha.2013.06.016","article-title":"Voriconazole for fungal keratitis","volume":"120","author":"Prajna","year":"2013","journal-title":"Ophthalmology"},{"key":"2026102202150873000_110.11.1306.22","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl392"},{"key":"2026102202150873000_110.11.1306.23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/pharmaceutics15010035","article-title":"Antifungal Combination Eye Drops for Fungal Keratitis Treatment","volume":"15","author":"D\u00edaz-Tom\u00e9","year":"2022","journal-title":"Pharmaceutics"},{"key":"2026102202150873000_110.11.1306.24","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1007\/s12325-023-02541-x","article-title":"Natamycin Ocular Delivery: Challenges and Advancements in Ocular Therapeutics","volume":"40","author":"Mascarenhas","year":"2023","journal-title":"Adv Ther"},{"key":"2026102202150873000_110.11.1306.25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/APO.0000000000000035","article-title":"Topical 5% Natamycin With Oral Ketoconazole in Filamentous Fungal Keratitis: A Randomized Controlled Trial","volume":"4","author":"Rajaraman","year":"2015","journal-title":"Asia Pac J Ophthalmol (Phila)"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2025-328695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:16:24Z","timestamp":1792660584000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2025-328695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,10,22]]},"published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1136\/bjo-2025-328695"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2025-328695","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}