{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:03:58Z","timestamp":1790071438332,"version":"4.0.1"},"reference-count":26,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,3,15]]},"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify predictive factors of remission in patients with sarcoid uveitis and to evaluate recurrence rates and patterns following remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre retrospective study of patients with sarcoid uveitis and a minimum follow-up of 3 years. Remission was defined as the absence of clinical symptoms of sarcoidosis for at least 3 years without treatment. Remission-free Kaplan-Meier survival curves were constructed for selected variables. Cox proportional hazards model was then applied. HRs and 95%\u2009CIs were estimated for each variable. Statistical significance was set at the p&lt;0.05 level. Rates and patterns of recurrence after remission were collected and compared with initial presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 329\u2009patients were included (62% female, median age 53 years). Remission occurred in 98 (30%) patients after a median follow-up of 6.5 years. Macular oedema at baseline was associated with a lower likelihood of remission (HR, 0.594, 95%\u2009CI 0.342 to 0.996, p=0.043), whereas pulmonary involvement at baseline was associated with a higher likelihood of remission (HR, 1.588, 95%\u2009CI 1.047 to 2.419, p=0.032). Recurrence after remission occurred in 6 of 98\u2009patients (6%), with a median time to recurrence of 46\u2009months after remission. At recurrence, patients predominantly had anterior uveitis (83%) and shared similar anatomical patterns with their initial presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately one in three patients with sarcoid uveitis achieved remission. Macular oedema at baseline was associated with delayed remission, while lung involvement at baseline was associated with faster remission. Recurrence after remission was uncommon and typically mirrored the initial uveitis phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328902","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:20:19Z","timestamp":1775064019000},"page":"1195-1200","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Remission in sarcoid uveitis: identification of predictive factors"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9172-7530","authenticated-orcid":false,"given":"Amy","family":"Siriphanh","sequence":"first","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Department of Internal Medicine, H\u00f4pital de la Croix-Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-995X","authenticated-orcid":false,"given":"Robin","family":"Jacquot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital de la Croix-Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Subtil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Service de Biostatistiques, Hospices Civils de Lyon, Lyon, France"},{"name":"CNRS, Laboratoire de Biom\u00e9trie et Biologie Evolutive, UMR 5558, Universit\u00e9 Lyon 1, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9430-5701","authenticated-orcid":false,"given":"Margot","family":"Cargnelutti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital de la Croix-Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"El Jammal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital de la Croix-Rousse, Lyon, France"},{"name":"Hospices Civils de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"P\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centre Hospitalier Saint Joseph Saint Luc, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Burillon","sequence":"additional","affiliation":[{"name":"Rh\u00f4ne-Alpes, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Department of Ophthalmology, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-6716","authenticated-orcid":false,"given":"Laurent","family":"Kodjikian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Department of Ophthalmology, H\u00f4pital de la Croix-Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"S\u00e8ve","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Department of Internal Medicine, H\u00f4pital de la Croix-Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Abramowicz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital de la Croix-Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"2026092202200734000_110.10.1195.1","first-page":"52","article-title":"The late follow-up of chronic sarcoid patients previously treated with corticosteroids","volume":"15","author":"Rizzato","year":"1998","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026092202200734000_110.10.1195.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199903000-00001"},{"key":"2026092202200734000_110.10.1195.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.3.623"},{"key":"2026092202200734000_110.10.1195.4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12093194","article-title":"Sarcoidosis-Related Uveitis: A Review","volume":"12","author":"Giorgiutti","year":"2023","journal-title":"J Clin Med"},{"key":"2026092202200734000_110.10.1195.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309767"},{"key":"2026092202200734000_110.10.1195.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30417-X"},{"key":"2026092202200734000_110.10.1195.7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.5301\/EJO.2011.6417","article-title":"Visual outcome in ocular sarcoidosis: retrospective evaluation of risk factors","volume":"21","author":"Miserocchi","year":"2011","journal-title":"Eur J Ophthalmol"},{"key":"2026092202200734000_110.10.1195.8","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1016\/j.lpm.2012.04.004","article-title":"Ocular sarcoidosis","volume":"41","author":"Bodaghi","year":"2012","journal-title":"La Presse M\u00e9dicale"},{"key":"2026092202200734000_110.10.1195.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(02)00021-4"},{"key":"2026092202200734000_110.10.1195.10","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.3390\/jcm9123894","article-title":"Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis","volume":"9","author":"Bienvenu","year":"2020","journal-title":"JCM"},{"key":"2026092202200734000_110.10.1195.11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1975"},{"key":"2026092202200734000_110.10.1195.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00055213"},{"key":"2026092202200734000_110.10.1195.13","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1001\/jamaophthalmol.2017.4771","article-title":"Diagnostic Value of Serum-Soluble Interleukin 2 Receptor Levels vs Angiotensin-Converting Enzyme in Patients With Sarcoidosis-Associated Uveitis","volume":"135","author":"Groen-Hakan","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"2026092202200734000_110.10.1195.14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147258","article-title":"Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis","volume":"11","author":"Gundlach","year":"2016","journal-title":"PLoS ONE"},{"key":"2026092202200734000_110.10.1195.15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-313133"},{"key":"2026092202200734000_110.10.1195.16","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-313356"},{"key":"2026092202200734000_110.10.1195.17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.revmed.2010.09.003","article-title":"Sarcoid uveitis: Diagnostic and therapeutic update","volume":"32","author":"Varron","year":"2011","journal-title":"Rev Med Interne"},{"key":"2026092202200734000_110.10.1195.18","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1595578"},{"key":"2026092202200734000_110.10.1195.19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"2026092202200734000_110.10.1195.20","first-page":"242","article-title":"The importance of PET\/CT findings and hematological parameters in prediction of progression in sarcoidosis cases","volume":"34","author":"Tertemiz","year":"2017","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026092202200734000_110.10.1195.21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajo.2017.02.028","article-title":"Clinical Outcome of Retinal Vasculitis and Predictors for Prognosis of Ischemic Retinal Vasculitis","volume":"177","author":"Sharief","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"2026092202200734000_110.10.1195.22","first-page":"2675","article-title":"Increased vitreous levels of B cell activation factor (BAFF) and soluble interleukin-6 receptor in patients with macular edema due to uveitis related to Beh\u00e7et\u2019s disease and sarcoidosis","volume":"260","author":"Takeda","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2026092202200734000_110.10.1195.23","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9244"},{"key":"2026092202200734000_110.10.1195.24","article-title":"Particles exposures and sarcoidosis","volume":"42","author":"Ghio","year":"2025","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026092202200734000_110.10.1195.25","doi-asserted-by":"crossref","unstructured":"Nagata K , Eishi Y , Uchida K , et al . n.d. Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis. Sci Rep 7. doi:10.1038\/s41598-017-15710-0","DOI":"10.1038\/s41598-017-15710-0"},{"key":"2026092202200734000_110.10.1195.26","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.52"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2025-328902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:21:33Z","timestamp":1790068893000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2025-328902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,22]]},"published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1136\/bjo-2025-328902"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2025-328902","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}