{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:05:19Z","timestamp":1779271519187,"version":"3.51.4"},"reference-count":19,"publisher":"BMJ","issue":"6","funder":[{"name":"Jochum Jensen og hustru Mette Marie Jensen, f. Poulsens Mindelegat","award":["No grant\/award number"],"award-info":[{"award-number":["No grant\/award number"]}]},{"name":"Kirsten Friis-Nielsens Forskningsfond","award":["No grant\/award number"],"award-info":[{"award-number":["No grant\/award number"]}]},{"DOI":"10.13039\/100019562","name":"Synoptik-Fonden","doi-asserted-by":"publisher","award":["No grant\/award number"],"award-info":[{"award-number":["No grant\/award number"]}],"id":[{"id":"10.13039\/100019562","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fight for Sight Denmark","award":["No grant\/award number"],"award-info":[{"award-number":["No grant\/award number"]}]},{"name":"Helene og Viggo Bruuns Fond","award":["No grant\/award number"],"award-info":[{"award-number":["No grant\/award number"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,11,25]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate corneal higher order aberrations (HOAs), densitometry and whole-eye optical quality after ultrathin Descemet\u2019s stripping automated endothelial keratoplasty (UT-DSAEK), Descemet\u2019s membrane endothelial keratoplasty (DMEK) and cataract surgery and the association with visual function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This predefined secondary analysis of a randomised trial included 72\u2009patients with Fuchs\u2019 endothelial dystrophy (FED) and cataract for UT-DSAEK or DMEK combined with cataract surgery. Thirty-seven patients with cataract and healthy corneas served as controls and underwent cataract surgery alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total posterior HOAs were significantly higher 12\u2009months after UT-DSAEK than DMEK (p&lt;0.001) and higher after DMEK than in the control group (p&lt;0.01).<\/jats:p>\n                    <jats:p>Total densitometry for the central (0\u20132\u2009mm) and peripheral (2\u20136\u2009mm) annular corneal zones was significantly higher 12\u2009months after UT-DSAEK than DMEK (p&lt;0.01\u2009for both comparisons).<\/jats:p>\n                    <jats:p>\n                      Objective scatter index (OSI) was significantly higher 12\u2009months after UT-DSAEK than DMEK (p&lt;0.01) and higher after DMEK than in the control group (p&lt;0.001). For patients treated with endothelial keratoplasty, visual acuity and OSI were significantly correlated (r\n                      <jats:sup>2<\/jats:sup>\n                      =0.55, p&lt;0.001), as were contrast sensitivity and OSI (r\n                      <jats:sup>2<\/jats:sup>\n                      =0.37, p&lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Total posterior HOAs and OSI were higher 12\u2009months after UT-DSAEK than after DMEK and higher after DMEK than after cataract surgery alone. Visual acuity and contrast sensitivity were correlated with OSI. Although DMEK surgery for FED provides excellent visual rehabilitation, the corneal optical quality remains suboptimal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04417959\">NCT04417959<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-328970","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:35:14Z","timestamp":1765452914000},"page":"607-614","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Optical quality after ultrathin Descemet\u2019s stripping automated endothelial keratoplasty and Descemet\u2019s membrane endothelial keratoplasty: a randomised controlled clinical trial"],"prefix":"10.1136","volume":"110","clinical-trial-number":[{"clinical-trial-number":"nct04417959","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04417959","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1858-0464","authenticated-orcid":false,"given":"Morten Brok Molbech","family":"Madsen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ivarsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"2026052002050984000_110.6.607.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.05.019"},{"key":"2026052002050984000_110.6.607.2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002601"},{"key":"2026052002050984000_110.6.607.3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2023-323304"},{"key":"2026052002050984000_110.6.607.4","doi-asserted-by":"crossref","first-page":"e1127","DOI":"10.1111\/aos.14741","article-title":"Quality of vision and vision-related quality of life after Descemet membrane endothelial keratoplasty: a randomized clinical trial","volume":"99","author":"Dunker","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"2026052002050984000_110.6.607.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.02.007"},{"key":"2026052002050984000_110.6.607.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.02.009"},{"key":"2026052002050984000_110.6.607.7","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jamaophthalmol.2013.73","article-title":"Effects of graft thickness and asymmetry on visual gain and aberrations after descemet stripping automated endothelial keratoplasty","volume":"131","author":"Dickman","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"2026052002050984000_110.6.607.8","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1097\/ICO.0b013e3182a9b182","article-title":"Post-DSAEK optical changes: a comprehensive prospective analysis on the role of ocular wavefront aberrations, haze, and corneal 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