{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:08:19Z","timestamp":1788991699371,"version":"build-2803163510"},"reference-count":38,"publisher":"BMJ","funder":[{"name":"Bureau of Science and Technology of Handan city, Hebei Province, China","award":["No. 2006-10903"],"award-info":[{"award-number":["No. 2006-10903"]}]},{"name":"the Program of Health Policy for Blindness Prevention from the People\u2019s Republic of China, partially funded by the Key Technologies R&D Program","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"the Ministry of Science and Technology of the People\u2019s Republic of China","award":["Grant 2007CB512201"],"award-info":[{"award-number":["Grant 2007CB512201"]}]},{"name":"the National Basic Research Program of China","award":["973 Program"],"award-info":[{"award-number":["973 Program"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,8,18]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the association between visual impairment (VI) and cognitive impairment in middle-aged and older adults from a rural Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Handan Eye Follow-up Study was conducted between 2012 and 2013. All participants underwent a standardised ophthalmic examination, structured interview and mobility performance assessment. The ophthalmic examination included visual acuity (VA) measurement and a comprehensive clinical eye examination. The interview collected demographic characteristics, cognitive status assessed by the Mini-Mental State Examination (MMSE) and general information related to medical conditions. Mobility performance was evaluated using walking speed tests, standing balance tests and the Timed Up and Go Test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 5394 participants in the Handan Eye Follow-up Study, 3794 were aged \u226550 years, of whom 3650 completed both VA and cognitive assessments. The prevalence of distance VI and near VI was 27.53% and 91.99%, respectively. Linear regression analyses revealed that distance VI was associated with a 1.53-fold higher likelihood of poorer MMSE scores after adjustment for demographic variables (p&lt;0.01); however, this association was not statistically significant after further adjustment for all covariates (p=0.23). Near VI was associated with a 2.21-fold higher likelihood of poorer MMSE scores following initial adjustment (p=0.025), and this association remained significant after full adjustment (OR= 3.44, p=0.028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Near VI was associated with poorer cognitive performance in a rural Chinese population of middle-aged and older adults, highlighting the potential role of correctable vision loss in cognitive health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-329310","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:30:12Z","timestamp":1788989412000},"page":"bjo-2025-329310","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Visual impairment and its association with cognitive impairment: the Handan Eye Follow-up 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