{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:28:34Z","timestamp":1790083714540,"version":"4.0.1"},"reference-count":42,"publisher":"BMJ","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China","award":["U24A200954"],"award-info":[{"award-number":["U24A200954"]}]},{"name":"the Sanming Project of Medicine in Shenzhen","award":["SZSM202411007"],"award-info":[{"award-number":["SZSM202411007"]}]},{"name":"Key Project Fund of National Natural Science Foundation","award":["82230031"],"award-info":[{"award-number":["82230031"]}]},{"DOI":"10.13039\/501100002858","name":"the China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2025M772110"],"award-info":[{"award-number":["2025M772110"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shenzhen Natural Science Foundation","award":["JCYJ20250604184015019"],"award-info":[{"award-number":["JCYJ20250604184015019"]}]},{"name":"the Shenzhen Medical Research Fund","award":["C2401007"],"award-info":[{"award-number":["C2401007"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82301223"],"award-info":[{"award-number":["82301223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271102"],"award-info":[{"award-number":["82271102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82571229"],"award-info":[{"award-number":["82571229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,4,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>To evaluate cone morphology, retinal sublayer thicknesses and vessel density (VD) and their associations with retinal sensitivity (RS) in red-green colour vision deficiency (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>36 patients with red-green CVD and 38 age-matched controls were enrolled. Diagnosis was confirmed by pseudoisochromatic plates and the Farnsworth-Munsell 100-hue test. All participants underwent adaptive optics scanning laser ophthalmoscopy (AO-SLO), optical coherence tomography (OCT), OCT-angiography and microperimetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with red-green CVD exhibited significantly decreased cone density and regularity, increased cone dispersion and spacing at 3\u00b0 eccentricity, and thinner myoid and ellipsoid zone (MEZ) and outer segment (OS) (all p&lt;0.01). VDs, blue-yellow error score and axial length did not differ between groups. Patients with CVD had higher red-green error scores and lower RS (p&lt;0.05). Temporal cone density was correlated with RS only in CVD (r=0.410, p=0.011). Mean cone density correlated with favourable cone parameters and MEZ thickness (r=\u22120.827 to 0.862, p&lt;0.005) and predicted higher RS (r=0.463, p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Red-green CVD features reduced cone density, disorganised arrangement and MEZ and OS thinning, which are closely linked to RS. Cone structural integrity has clinical value for managing visual impairments in CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2025-329412","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:25:12Z","timestamp":1777051512000},"page":"bjo-2025-329412","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Cone structure and retinal sensitivity assessment in patients with red-green colour vision deficiency using multimodal imaging"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-6442","authenticated-orcid":false,"given":"Jia","family":"Liang","sequence":"first","affiliation":[{"name":"Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China"},{"name":"Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, 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