{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:36:48Z","timestamp":1786988208545,"version":"build-2736575974"},"reference-count":5,"publisher":"BMJ","funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CL-2017-06-001 (to P.I.S.)"],"award-info":[{"award-number":["CL-2017-06-001 (to P.I.S.)"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["224643\/Z\/21\/Z (to P.I.S)"],"award-info":[{"award-number":["224643\/Z\/21\/Z (to P.I.S)"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR 203308 (to P.I.S. and K.H.)"],"award-info":[{"award-number":["NIHR 203308 (to P.I.S. and K.H.)"]}],"id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,7,17]]},"abstract":"<jats:p>This report presents the clinical, electrophysiological and multimodal imaging findings of an individual with bilateral vitelliform maculopathy. Adaptive optics imaging enables in vivo visualisation of retinal microstructure at cellular resolution, providing a detailed baseline for longitudinal assessment and a potential outcome measure for future cellular-targeted therapies.<\/jats:p>","DOI":"10.1136\/bjo-2026-329595","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:20:25Z","timestamp":1786987225000},"page":"bjo-2026-329595","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive optics imaging in bilateral vitelliform maculopathy"],"prefix":"10.1136","author":[{"given":"Darren","family":"Hargreaves","sequence":"first","affiliation":[{"name":"Manchester University NHS Foundation Trust, Manchester Royal Eye Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hagan","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust, Manchester Royal Eye Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Delaney","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust, Manchester Royal Eye Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Gray","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust, Manchester Royal Eye Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Sergouniotis","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust, Manchester Royal Eye Hospital, Manchester, UK"},{"name":"Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-9135","authenticated-orcid":false,"given":"Karen Mary","family":"Hampson","sequence":"additional","affiliation":[{"name":"Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026081710201358000_bjo-2026-329595v1.1","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-021-00066-7","article-title":"Adaptive optics for high-resolution imaging","volume":"1","author":"Hampson","year":"2021","journal-title":"Nat Rev Methods Primers"},{"key":"2026081710201358000_bjo-2026-329595v1.2","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2024.100675","article-title":"Automated Cone Photoreceptor Detection in Adaptive Optics Flood Illumination Ophthalmoscopy","volume":"5","author":"Wooning","year":"2025","journal-title":"Ophthalmol Sci"},{"key":"2026081710201358000_bjo-2026-329595v1.3","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.63.8.27","article-title":"Photoreceptor and Retinal Pigment Epithelium Relationships in Eyes With Vitelliform Macular Dystrophy Revealed by Multimodal Adaptive Optics Imaging","volume":"63","author":"Liu","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2026081710201358000_bjo-2026-329595v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2023.01.009"},{"key":"2026081710201358000_bjo-2026-329595v1.5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.oret.2022.11.014","article-title":"Choroidal Neovascularization Is Common in Best Vitelliform Macular Dystrophy and Plays a Role in Vitelliform Lesion Evolution","volume":"7","author":"Han","year":"2023","journal-title":"Ophthalmol Retina"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2026-329595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:20:26Z","timestamp":1786987226000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2026-329595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":5,"alternative-id":["10.1136\/bjo-2026-329595"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2026-329595","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}