{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:28:23Z","timestamp":1787218103763,"version":"build-2736575974"},"reference-count":21,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,5,18]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Corneal neovascularisation (NV) is a refractory condition associated with lipid deposition, scarring and vision loss. Mitomycin C (MMC) intravascular chemoembolisation (MICE) has shown early promise but real-world data remain limited. This study evaluates the efficacy and safety of MICE and MMC intrastromal injection (MIST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case series of patients with corneal NV treated with MICE and\/or MIST at Moorfields Eye Hospital between March 2023 and March 2025. NV regression was assessed using (1) ImageJ quantitative analysis, (2) masked independent grading of slit-lamp photographs and (3) surgeon-reported outcomes. Corrected distance visual acuity and complications were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>39 procedures were performed; median follow-up was 12 months. MIST alone was performed in 70% as intravascular cannulation was achieved in only 15%. NV regression was demonstrated in 59% by ImageJ analysis, 71% by independent grading and 81% by surgeon-reported outcomes. Four patients subsequently underwent successful keratoplasty without NV recurrence. Most complications were mild and self-limiting. Two serious complications involving anterior chamber MMC migration occurred in eyes with significant corneal thinning or prior perforation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the largest cohort reported to date, MICE and MIST represent effective angio-regressive strategies for refractory corneal NV. MIST alone produces meaningful vascular regression, offering a more accessible surgical approach. MMC-based angio-regression appears to be the most effective treatment currently available and may have an important role in stabilising high-risk corneas prior to keratoplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2026-329997","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:20:21Z","timestamp":1780075221000},"page":"990-996","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mitomycin C-based angio-regression for corneal neovascularisation: outcomes with intravascular (MICE), intrastromal (MIST) and combined delivery routes"],"prefix":"10.1136","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-9647","authenticated-orcid":false,"given":"Alice L","family":"Milligan","sequence":"first","affiliation":[{"name":"External Diseases Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK"},{"name":"Blood Safety and Hepatitis, UKHSA, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C","family":"Day","sequence":"additional","affiliation":[{"name":"External Diseases Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK"},{"name":"NIHR Moorfields Biomedical Research Centre, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yin","family":"Koay","sequence":"additional","affiliation":[{"name":"External Diseases Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-9162","authenticated-orcid":false,"given":"Mark","family":"Wilkins","sequence":"additional","affiliation":[{"name":"External Diseases Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK"},{"name":"University College London, Faculty of Brain Sciences, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Maurino","sequence":"additional","affiliation":[{"name":"External Diseases Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Watson","sequence":"additional","affiliation":[{"name":"External Diseases Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"2026082002151214000_110.9.990.1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s40123-020-00309-y","article-title":"Lipid Keratopathy: A Review of Pathophysiology, Differential Diagnosis, and Management","volume":"9","author":"Hall","year":"2020","journal-title":"Ophthalmol 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CASE REPORT: Outcomes of mitomycin C intravascular chemoembolization (MICE) in refractory corneal neovascularization after failed keratoplasty. 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