{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:35Z","timestamp":1792787255461,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","funder":[{"name":"National Research Foundation of Korea","award":["NRF-2021R1A2C2093617"],"award-info":[{"award-number":["NRF-2021R1A2C2093617"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,9,22]]},"DOI":"10.1136\/bjo-2026-330371","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:20:20Z","timestamp":1792516820000},"page":"bjo-2026-330371","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Axial elongation is associated with stress-dominant aqueous humour proteomic changes in eyes with and without open-angle glaucoma"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-5627","authenticated-orcid":false,"given":"Hee Jong","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, The Catholic University of Korea Seoul St Mary\u2019s Hospital, Seocho-gu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-5332","authenticated-orcid":false,"given":"Hae Young Lopilly","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, The Catholic University of Korea Seoul St Mary\u2019s Hospital, Seocho-gu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-724X","authenticated-orcid":false,"given":"Chan Kee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, The Catholic University of Korea Seoul St Mary\u2019s Hospital, Seocho-gu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"2026102010200932000_bjo-2026-330371v1.1","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.61.4.49","article-title":"The Complications of Myopia: A Review and Meta-Analysis","volume":"61","author":"Haarman","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2026102010200932000_bjo-2026-330371v1.2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.56920\/cehj.568","article-title":"Myopia: a growing global problem with sight-threatening complications","volume":"28","author":"Holden","year":"2015","journal-title":"Community Eye Health"},{"key":"2026102010200932000_bjo-2026-330371v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.03.012"},{"key":"2026102010200932000_bjo-2026-330371v1.4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ajo.2021.10.007","article-title":"Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-analysis","volume":"236","author":"Ha","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"2026102010200932000_bjo-2026-330371v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00063-0"},{"key":"2026102010200932000_bjo-2026-330371v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.08.009"},{"key":"2026102010200932000_bjo-2026-330371v1.7","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1112996","article-title":"Evidence of vascular involvement in myopia: a review","volume":"10","author":"Benavente-Perez","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"2026102010200932000_bjo-2026-330371v1.8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.18240\/ijo.2022.03.21","article-title":"Scleral remodeling in myopia development","volume":"15","author":"Yu","year":"2022","journal-title":"Int J Ophthalmol"},{"key":"2026102010200932000_bjo-2026-330371v1.9","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1397461","article-title":"Advances in aqueous humor proteomics for biomarker discovery and disease mechanisms exploration: a spotlight on primary open angle glaucoma","volume":"17","author":"Beutgen","year":"2024","journal-title":"Front Mol Neurosci"},{"key":"2026102010200932000_bjo-2026-330371v1.10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165314","article-title":"Changes to the Aqueous Humor Proteome during Glaucoma","volume":"11","author":"Kaeslin","year":"2016","journal-title":"PLoS One"},{"key":"2026102010200932000_bjo-2026-330371v1.11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23434"},{"key":"2026102010200932000_bjo-2026-330371v1.12","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1021\/acs.jproteome.3c00630","article-title":"Comparative Proteomic Analysis of Aqueous Humor Reveals Biochemical Disparities in the Eyes of High Myopic Patients","volume":"23","author":"Du","year":"2024","journal-title":"J Proteome Res"},{"key":"2026102010200932000_bjo-2026-330371v1.13","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.13.6.17","article-title":"Implications of Ocular Confounding Factors for Aqueous Humor Proteomic and Metabolomic Analyses in Retinal Diseases","volume":"13","author":"Titz","year":"2024","journal-title":"Transl Vis Sci Technol"},{"key":"2026102010200932000_bjo-2026-330371v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90416-5"},{"key":"2026102010200932000_bjo-2026-330371v1.15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5114-08.2008"},{"key":"2026102010200932000_bjo-2026-330371v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.08.008"},{"key":"2026102010200932000_bjo-2026-330371v1.17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41434-021-00281-7","article-title":"XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma","volume":"29","author":"Visuvanathan","year":"2022","journal-title":"Gene Ther"},{"key":"2026102010200932000_bjo-2026-330371v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400712"},{"key":"2026102010200932000_bjo-2026-330371v1.19","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"key":"2026102010200932000_bjo-2026-330371v1.20","doi-asserted-by":"publisher","DOI":"10.1006\/smim.2000.0210"},{"key":"2026102010200932000_bjo-2026-330371v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/nature24676"},{"key":"2026102010200932000_bjo-2026-330371v1.22","article-title":"Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway","volume":"2","author":"Au-Yeung","year":"2013","journal-title":"JAKSTAT"},{"key":"2026102010200932000_bjo-2026-330371v1.23","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.6.3989"},{"key":"2026102010200932000_bjo-2026-330371v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.09.014"},{"key":"2026102010200932000_bjo-2026-330371v1.25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172481","article-title":"Characterization of the human aqueous humour proteome: A comparison of the genders","volume":"12","author":"Perumal","year":"2017","journal-title":"PLoS One"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2026-330371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:20:21Z","timestamp":1792516821000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2026-330371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":25,"alternative-id":["10.1136\/bjo-2026-330371"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2026-330371","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]}}}