{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:38Z","timestamp":1792787258046,"version":"4.5.0"},"reference-count":23,"publisher":"BMJ","funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["567266264"],"award-info":[{"award-number":["567266264"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess radial changes in the retinal nerve fibre layer thickness (RNFLT) in the temporal parapapillary region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using radial optical coherence tomographic images of the optic nerve head, we measured in a sample of participants of the population-based Beijing Eye Study the RNFLT in the temporal horizontal parapapillary region at locations \u2018A\u2019 (intact inner (INL) and outer (ONL) nuclear layer), \u2018B\u2019 (INL\/ONL end), \u2018C\u2019 (just beyond the INL\/ONL end) in the parapapillary gamma zone centre and at the disc border. Exclusion criterion was any optic nerve damage including glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 47 eyes (47 participants). RNFLT increased (p&lt;0.001) from 86\u00b124\u2009\u00b5m at \u2018A\u2019 (optic disc centre distance (ODCD): 1523\u00b1477\u2009\u00b5m) to 128\u00b142\u2009\u00b5m at \u2018B\u2019 (ODCD: 1192\u00b1394\u2009\u00b5m) and to 190\u00b164\u2009\u00b5m at \u2018C\u2019 (ODCD: 1023\u00b1312\u2009\u00b5m). The increasing RNFLT measurements from location \u2018A\u2019 to \u2018B\u2019 by 49% and from \u2018B\u2019 to \u2018C\u2019 by 49% were double as high as geometrically expected (\u2018A\u2019 to \u2018B\u2019: 1523\u2009\u00b5m\/1192\u2009\u00b5m (28%); \u2018B\u2019 to \u2018C\u2019: 1192\u2009\u00b5m\/1023\u2009\u00b5m (17%)). In the temporal parapapillary gamma zone (detected in 23 eyes), RNFLT changed from the mid of gamma zone (ODCD: 1069\u00b1291\u2009\u00b5m) to the disc border (ODCD: 618\u00b1228\u2009\u00b5m) from 210\u00b176\u2009\u00b5m to 238\u00b181\u2009\u00b5m (or +13%), while the ODCD decreased by 42%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RNFLT in the temporal horizontal parapapillary region markedly increased just beyond (in direction to the disc border) of the INL\/ONL end while within gamma zone RNFLT changed only marginally. Absence of underlying INL\/ONL was associated with pronounced RNFL thickening, without major further radial RNFLT changes in gamma zone. These findings may be of importance for RNFLT measurements in highly myopic eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2026-330479","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:20:20Z","timestamp":1791393620000},"page":"bjo-2026-330479","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal nerve fibre layer thickness change in the parapapillary region"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B","family":"Jonas","sequence":"first","affiliation":[{"name":"Institute Francais de Myopie, Rothschild Foundation Hospital, Paris, France"},{"name":"Singapore Eye Research Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul A","family":"Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda-Jonas","sequence":"additional","affiliation":[{"name":"Medical Faculty Ruprecht-Karls-University Heidelberg, Department of Ophthalmology, Heidelberg, 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