{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:13:21Z","timestamp":1788286401233,"version":"build-2803163510"},"reference-count":46,"publisher":"BMJ","funder":[{"name":"Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission","award":["23SG14"],"award-info":[{"award-number":["23SG14"]}]},{"name":"Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China","award":["JYB2025XDXM611"],"award-info":[{"award-number":["JYB2025XDXM611"]}]},{"name":"Science and Technology Commission of Shanghai","award":["20DZ2270800"],"award-info":[{"award-number":["20DZ2270800"]}]},{"name":"Science and Technology Commission of Shanghai","award":["25Y22800200"],"award-info":[{"award-number":["25Y22800200"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272642"],"award-info":[{"award-number":["82272642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322017"],"award-info":[{"award-number":["82322017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82388101"],"award-info":[{"award-number":["82388101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Clinical Key Specialties Program","award":["Not Applicable"],"award-info":[{"award-number":["Not Applicable"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,8,21]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate survival, globe salvage and visual outcomes of globe-preserving treatment approaches in unilateral cT2 and cT3 retinoblastoma, with a focus on cT3 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre, retrospective cohort study enrolled 1566 treatment-na\u00efve unilateral retinoblastoma eyes (870 clinical (c)T2, 696 cT3 by eighth American Joint Committee on Cancer clinical tumour, node, metastases staging) from 11 Chinese tertiary centres. Patients underwent intra-arterial chemotherapy, intravenous chemotherapy or primary enucleation. Outcomes were globe salvage, overall survival, metastasis-free survival, high-risk histopathological feature prevalence and vision-preserving rate (\u2265light perception (LP)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this multicentre cohort of 1566 eyes, the globe-salvage rate across cT2 and cT3 retinoblastoma was higher with intra-arterial chemotherapy than with intravenous chemotherapy. When stratified by cT3 subcategories, intra-arterial chemotherapy achieved significantly higher globe-salvage rates than intravenous chemotherapy in cT3b eyes (HR 3.65; 95% CI 1.91 to 6.98)\u2009and cT3c eyes (HR 4.02; 95% CI 2.79 to 5.80). In contrast, globe salvage did not differ between intra-arterial chemotherapy and intravenous chemotherapy in cT3d eyes. Overall survival and metastasis-free survival did not differ between intra-arterial chemotherapy and primary enucleation. Among eyes with cT3b or cT3c disease, 79.4% of eyes salvaged with intra-arterial chemotherapy and 65.0% of eyes salvaged with intravenous chemotherapy retained at least LP. Detected high-risk pathological features were not significantly different between eyes treated with intra-arterial chemotherapy and those undergoing primary enucleation in cT3b or cT3c disease. Among secondary enucleated eyes with cT3d disease, intra-arterial chemotherapy was associated with lower rates of choroidal invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intra-arterial chemotherapy may enable globe salvage in cT3b\/c retinoblastoma, whereas cT3d eyes continue to warrant prompt enucleation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2026-330597","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:20:19Z","timestamp":1788283219000},"page":"bjo-2026-330597","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of globe-preserving therapies in unilateral cT2\/cT3 retinoblastoma: a multicentre study of 1566 eyes"],"prefix":"10.1136","author":[{"given":"Yiran","family":"Yao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingpeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglei","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinji","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishuang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Children\u2019s Hospital, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6504-2467","authenticated-orcid":false,"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-452X","authenticated-orcid":false,"given":"Yang-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, Changsha, China"},{"name":"Hunan Key Laboratory of Ophthalmology, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Jin","sequence":"additional","affiliation":[{"name":"Quanzhou Aier Eye Hospital, Quanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Departement of Ophthalmology, Beijing Children\u2019s Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunda","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-0940","authenticated-orcid":false,"given":"Peiwei","family":"Chai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-4379","authenticated-orcid":false,"given":"Xuyang","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-1391","authenticated-orcid":false,"given":"Jiayan","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-7451","authenticated-orcid":false,"given":"Renbing","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026090110201244000_bjo-2026-330597v1.1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMicm2118356","article-title":"Retinoblastoma","volume":"386","author":"Peeler","year":"2022","journal-title":"N Engl J Med"},{"key":"2026090110201244000_bjo-2026-330597v1.2","doi-asserted-by":"crossref","first-page":"15021","DOI":"10.1038\/nrdp.2015.21","article-title":"Retinoblastoma","volume":"1","author":"Dimaras","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2026090110201244000_bjo-2026-330597v1.3","doi-asserted-by":"crossref","first-page":"e1128","DOI":"10.1016\/S2214-109X(22)00250-9","article-title":"The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries","volume":"10","author":"Fabian","year":"2022","journal-title":"Lancet Glob Health"},{"key":"2026090110201244000_bjo-2026-330597v1.4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/jamaoncol.2019.6716","article-title":"Global Retinoblastoma Presentation and Analysis by National Income Level","volume":"6","author":"Fabian","year":"2020","journal-title":"JAMA Oncol"},{"key":"2026090110201244000_bjo-2026-330597v1.5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S2352-4642(23)00141-4","article-title":"Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial","volume":"7","author":"Wen","year":"2023","journal-title":"Lancet Child Adolesc Health"},{"key":"2026090110201244000_bjo-2026-330597v1.6","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.ophtha.2020.05.051","article-title":"A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma: Part II: Treatment Success and Globe Salvage","volume":"127","author":"Tomar","year":"2020","journal-title":"Ophthalmology"},{"key":"2026090110201244000_bjo-2026-330597v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.09.026"},{"key":"2026090110201244000_bjo-2026-330597v1.8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajo.2023.11.004","article-title":"Retinoblastoma Outcomes in the Americas: A Prospective Analysis of 491 Children With Retinoblastoma From 23 American Countries","volume":"260","author":"Berry","year":"2024","journal-title":"Am J Ophthalmol"},{"key":"2026090110201244000_bjo-2026-330597v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.018"},{"key":"2026090110201244000_bjo-2026-330597v1.10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ophtha.2022.04.022","article-title":"Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma: A Multicenter Registry-Based Study","volume":"129","author":"Tomar","year":"2022","journal-title":"Ophthalmology"},{"key":"2026090110201244000_bjo-2026-330597v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.12.014"},{"key":"2026090110201244000_bjo-2026-330597v1.12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamaophthalmol.2016.0244","article-title":"Intra-arterial Chemotherapy for Retinoblastoma: A Systematic Review","volume":"134","author":"Yousef","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"2026090110201244000_bjo-2026-330597v1.13","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309298"},{"key":"2026090110201244000_bjo-2026-330597v1.14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4143\/crt.2021.1537","article-title":"The Efficacy of Alternate Systemic Intravenous Chemotherapy and Intra-arterial Chemotherapy Approach for Eye Globe Salvage in Retinoblastoma","volume":"55","author":"Han","year":"2023","journal-title":"Cancer Res Treat"},{"key":"2026090110201244000_bjo-2026-330597v1.15","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2024-326452"},{"key":"2026090110201244000_bjo-2026-330597v1.16","doi-asserted-by":"crossref","unstructured":"Chen KY , Chan HC , Chan CM . Is intra-arterial chemotherapy superior to conventional chemotherapy for retinoblastoma? A systematic review and meta-analysis of efficacy and safety. Surv Ophthalmol 2025. doi:10.1016\/j.survophthal.2025.12.009","DOI":"10.1016\/j.survophthal.2025.12.009"},{"key":"2026090110201244000_bjo-2026-330597v1.17","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17121955","article-title":"Intra-Arterial Melphalan Chemotherapy for Retinoblastoma in a Developing Nation: Real-World Outcomes and Prognostic Factors","volume":"17","author":"Yousef","year":"2025","journal-title":"Cancers (Basel)"},{"key":"2026090110201244000_bjo-2026-330597v1.18","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-018-4406-6","article-title":"Comparison between intravenous chemotherapy and intra-arterial chemotherapy for retinoblastoma: a meta-analysis","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Cancer"},{"key":"2026090110201244000_bjo-2026-330597v1.19","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.150"},{"key":"2026090110201244000_bjo-2026-330597v1.20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/APO.0000000000000172","article-title":"Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma","volume":"5","author":"Shields","year":"2016","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"2026090110201244000_bjo-2026-330597v1.21","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.oret.2025.02.013","article-title":"Intra-arterial Chemotherapy for Retinoblastoma, Outcomes Analysis in 357 Eyes: Thirteen Years of Experience in a Referral Center in Brazil","volume":"9","author":"Teixeira","year":"2025","journal-title":"Ophthalmol Retina"},{"key":"2026090110201244000_bjo-2026-330597v1.22","doi-asserted-by":"crossref","DOI":"10.1136\/neurintsurg-2021-018409","article-title":"Correspondence on \u201cIntra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis\u201d by Ravindran et al","volume":"14","author":"Promelle","year":"2022","journal-title":"J Neurointerv Surg"},{"key":"2026090110201244000_bjo-2026-330597v1.23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/1591019918755088","article-title":"Improved procedural safety following protocol changes for selective ophthalmic arterial infusion of chemotherapy for treatment of ocular retinoblastoma","volume":"24","author":"Ammanuel","year":"2018","journal-title":"Interv Neuroradiol"},{"key":"2026090110201244000_bjo-2026-330597v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.034"},{"key":"2026090110201244000_bjo-2026-330597v1.25","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2025-327728"},{"key":"2026090110201244000_bjo-2026-330597v1.26","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.30071","article-title":"Ocular survival after intra-arterial chemotherapy for retinoblastoma improves with accrual of experience and programmatic evolution","volume":"70","author":"Marasligiller","year":"2023","journal-title":"Pediatr Blood Cancer"},{"key":"2026090110201244000_bjo-2026-330597v1.27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ophtha.2021.09.002","article-title":"Eye-Preserving Therapies for Advanced Retinoblastoma: A Multicenter Cohort of 1678 Patients in China","volume":"129","author":"Zhou","year":"2022","journal-title":"Ophthalmology"},{"key":"2026090110201244000_bjo-2026-330597v1.28","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.oret.2020.02.015","article-title":"Impact of Systemic Chemotherapy and Delayed Enucleation on Survival of Children with Advanced Intraocular Retinoblastoma","volume":"4","author":"Zhao","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"2026090110201244000_bjo-2026-330597v1.29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.5332"},{"key":"2026090110201244000_bjo-2026-330597v1.30","doi-asserted-by":"crossref","DOI":"10.1186\/s40942-017-0093-8","article-title":"Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide","volume":"3","author":"Abramson","year":"2017","journal-title":"Int J Retina Vitreous"},{"key":"2026090110201244000_bjo-2026-330597v1.31","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.223"},{"key":"2026090110201244000_bjo-2026-330597v1.32","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315572"},{"key":"2026090110201244000_bjo-2026-330597v1.33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ophtha.2017.01.048","article-title":"High-Risk Histopathology Features in Primary and Secondary Enucleated International Intraocular Retinoblastoma Classification Group D Eyes","volume":"124","author":"Fabian","year":"2017","journal-title":"Ophthalmology"},{"key":"2026090110201244000_bjo-2026-330597v1.34","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306364"},{"key":"2026090110201244000_bjo-2026-330597v1.35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/tjo.TJO-D-24-00107","article-title":"Evolving trends in retinoblastoma management: A 16-year clinicopathological analysis of enucleated eyes","volume":"15","author":"August","year":"2025","journal-title":"Taiwan J Ophthalmol"},{"key":"2026090110201244000_bjo-2026-330597v1.36","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303694"},{"key":"2026090110201244000_bjo-2026-330597v1.37","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310294"},{"key":"2026090110201244000_bjo-2026-330597v1.38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/jamaoncol.2019.6716","article-title":"Global Retinoblastoma Presentation and Analysis by National Income Level","volume":"6","author":"Fabian","year":"2020","journal-title":"JAMA Oncol"},{"key":"2026090110201244000_bjo-2026-330597v1.39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41433-025-04144-y","article-title":"Retinoblastoma outcomes in Europe: a prospective analysis of 483 patients from 40 countries","volume":"40","author":"Bowman","year":"2026","journal-title":"Eye (Lond)"},{"key":"2026090110201244000_bjo-2026-330597v1.40","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_866_19"},{"key":"2026090110201244000_bjo-2026-330597v1.41","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28963","article-title":"Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: A survey by the European Retinoblastoma Group (EURbG)","volume":"68","author":"Dittner-Moormann","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"2026090110201244000_bjo-2026-330597v1.42","first-page":"726","article-title":"Use of intra-arterial chemotherapy for retinoblastoma: results of a survey","volume":"7","author":"Grigorovski","year":"2014","journal-title":"Int J Ophthalmol"},{"key":"2026090110201244000_bjo-2026-330597v1.43","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316613"},{"key":"2026090110201244000_bjo-2026-330597v1.44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/2347-5625.207736","article-title":"Psychosocial Factors Influencing Parental Decision to Allow or Refuse Potentially Lifesaving Enucleation in Children with Retinoblastoma","volume":"4","author":"Domingo","year":"2017","journal-title":"Asia Pac J Oncol Nurs"},{"key":"2026090110201244000_bjo-2026-330597v1.45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/13816810.2014.937543","article-title":"Enucleation Refusal for Retinoblastoma: A Global Study","volume":"37","author":"Olteanu","year":"2016","journal-title":"Ophthalmic Genet"},{"key":"2026090110201244000_bjo-2026-330597v1.46","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2019-000415","article-title":"Role of ethnicity and socioeconomic status (SES) in the presentation of retinoblastoma: findings from the UK","volume":"5","author":"Bourkiza","year":"2020","journal-title":"BMJ Open Ophthalmol"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2026-330597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:20:23Z","timestamp":1788283223000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2026-330597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":46,"alternative-id":["10.1136\/bjo-2026-330597"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2026-330597","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}