{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:03:41Z","timestamp":1789495421854,"version":"build-2803163510"},"reference-count":24,"publisher":"BMJ","funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["12048(12) \/1\/2024-BP-IUCA"],"award-info":[{"award-number":["12048(12) \/1\/2024-BP-IUCA"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>To determine the prevalence and predictors of postoperative optic disc cupping reversal in primary congenital glaucoma (PCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective chart review included 1223 eyes of 775 children with primary congenital glaucoma who underwent surgery between 1993 and 2023 and had at least 1 year of follow-up. Baseline demographic and ocular parameters, including age-at-onset, age at surgery, laterality, intraocular pressure (IOP), cup-disc ratio (CDR), axial length (AL) and corneal diameter (CD), were recorded. CDR reversal was defined as a reduction in CDR of at least 0.2 from baseline. For bilateral PCG, both eyes were used for analysis; hence, cluster-robust standard errors were used. Univariable and multivariable logistic regression analyses were performed to identify factors associated with reversal and a scoring system for predicting CDR reversal in PCG eyes was developed from the model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative cupping reversal was observed in 528 of 1223 eyes (43.2%). On multivariable analysis, a smaller baseline CD and AL remained the strongest predictors of reversal, with every 1\u2009mm increase in CD being associated with a 50% reduction in the odds of postoperative CDR reversal (aOR 0.50, 95%\u2009CI 0.42 to 0.59; p&lt;0.001). Neonatal-onset (aOR 2.03, 95%\u2009CI 1.04 to 3.93; p=0.036) and infantile-onset disease (aOR 2.45, 95%\u2009CI 1.30 to 4.60; p=0.005) were also independently associated with reversal compared with late-onset PCG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postoperative CDR reversal occurs in a substantial proportion of PCG eyes and earlier disease onset, smaller CD and shorter AL are strong predictors for reversal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2026-330658","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:20:11Z","timestamp":1789492811000},"page":"bjo-2026-330658","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Reversal of optic disc cupping in primary congenital glaucoma: analysis of 1223 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"Biostatistics, All India Institute of Medical Sciences New Delhi, New Delhi, DL, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-3651","authenticated-orcid":false,"given":"Shikha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences New Delhi, New Delhi, DL, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-0485","authenticated-orcid":false,"given":"Viney","family":"Gupta","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences New Delhi, New Delhi, DL, 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