{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:28:51Z","timestamp":1787531331353,"version":"build-2736575974"},"reference-count":24,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Aim:<\/jats:title><jats:p>The aim of the study was to report the functional and morphological outcome of intraocular injection of sodium hyaluronate for treatment of chronic ocular hypotony (COH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We reviewed the digital chart records of patients with COH who had received one or more injections of intravitreal or intracameral sodium hyaluronate (1.4% or 2.3%). The changes in the best corrected visual acuity (BCVA) and intraocular pressure (IOP) after treatment were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Thirty-two eyes of 32 patients with a mean age of 56.8 years were analysed. Previous vitreoretinal surgery had been performed on all eyes for either ocular-penetrating trauma (six eyes), chronic uveitis (six eyes), full macular translocation (five eyes) or retinal detachment (15 eyes). Mean follow-up time after the first intraocular injection was 29.7 months. BCVA (logMAR) at the baseline and the last follow-up visit were 1.84 (SE 0.65) and 1.82 (SE 0.72), respectively (p\u200a=\u200a0.87). The mean IOP at the baseline increased from 2.28 (SE 0.27) mmHg to 7.12 (SE 1.03) mmHg at the last visit (p&lt;0.001). At the final follow-up, 20 eyes (62.5%) had an IOP higher than 5 mmHg and 24 eyes (75%) had an unchanged or improved BCVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Stabilisation of the IOP and vision in some eyes with COH following vitreoretinal surgery can be achieved with intraocular injection of sodium hyaluronate. Large case-series and long-term follow-up are necessary to confirm the beneficial role of intraocular sodium hyaluronate injections in such eyes.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo.2008.143834","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T00:44:57Z","timestamp":1222908297000},"page":"235-239","source":"Crossref","is-referenced-by-count":33,"title":["Treatment of chronic ocular hypotony with intraocular application of sodium hyaluronate"],"prefix":"10.1136","volume":"93","author":[{"given":"C","family":"K\u00fc\u00e7\u00fckerd\u00f6nmez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Beutel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K U","family":"Bartz-Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Gelisken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"2022020920550608000_93.2.235.1","first-page":"29","article-title":"Ocular hypotony: a review.","volume":"8","author":"Fine","year":"2007","journal-title":"Compr Ophthalmol Update"},{"key":"2022020920550608000_93.2.235.2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050045"},{"key":"2022020920550608000_93.2.235.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.11.019"},{"key":"2022020920550608000_93.2.235.4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0161-6420(99)00047-0","article-title":"The surgical management of hypotony.","volume":"107","author":"O\u2019Connell","year":"2000","journal-title":"Ophthalmology"},{"key":"2022020920550608000_93.2.235.5","doi-asserted-by":"crossref","unstructured":"Jonas JB Vossmerbaeumer U Kamppeter BA . Chronic prephthisical ocular hypotony treated by intravitreal triamcinolone acetonide. Acta Ophthalmol Scand 2004;82 :637.","DOI":"10.1111\/j.1600-0420.2004.00319.x"},{"key":"2022020920550608000_93.2.235.6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ajo.2005.09.034","article-title":"Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma.","volume":"141","author":"Ugahary","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"2022020920550608000_93.2.235.7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3928\/15428877-20060501-09","article-title":"The use of intravitreal gas for the treatment of ocular hypotony after glaucoma filtration surgery.","volume":"37","author":"Friedman","year":"2006","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"2022020920550608000_93.2.235.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0134-0"},{"key":"2022020920550608000_93.2.235.9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bjo.86.11.1225","article-title":"Combined perfluoropropane gas and viscoelastic material injection for anterior chamber reformation following trabeculectomy.","volume":"86","author":"Kurtz","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"2022020920550608000_93.2.235.10","first-page":"262","article-title":"Retinectomy lowers intraocular pressure in otherwise intractable glaucoma: preliminary results.","volume":"25","author":"Kirchhof","year":"1994","journal-title":"Ophthalmic Surg"},{"key":"2022020920550608000_93.2.235.11","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(83)90043-X"},{"key":"2022020920550608000_93.2.235.12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/BF00682804","article-title":"Animal experiments on the duration of retention of different vitreous body implants.","volume":"164","author":"Widder","year":"1962","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2022020920550608000_93.2.235.13","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(80)90093-7"},{"key":"2022020920550608000_93.2.235.14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF02134147","article-title":"Healon in retinal detachment with proliferative vitreoretinopathy.","volume":"221","author":"Gerke","year":"1984","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2022020920550608000_93.2.235.15","first-page":"351","article-title":"Hyaluronic acid as vitreous body replacement.","volume":"165","author":"Kloti","year":"1972","journal-title":"Ophthalmologica"},{"key":"2022020920550608000_93.2.235.16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3928\/1542-8877-20060301-05","article-title":"Intracameral 2.3% sodium hyaluronate to treat postoperative hypotony in patients with glaucoma.","volume":"37","author":"Altangerel","year":"2006","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"2022020920550608000_93.2.235.17","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1136\/bjo.87.9.1094","article-title":"Retinectomy for treatment of intractable glaucoma: long term results.","volume":"87","author":"Joussen","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"2022020920550608000_93.2.235.18","first-page":"872","article-title":"Can chronic bulbar hypotony be responsible for uveal effusion? Report of two cases.","volume":"20","author":"Daniele","year":"1989","journal-title":"Ophthalmic Surg"},{"key":"2022020920550608000_93.2.235.19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00137655","article-title":"Inflow and outflow relations after intraocular fluid-Healon exchange in a case of chronic ocular hypotension.","volume":"8","author":"Koerner","year":"1985","journal-title":"Int Ophthalmol"},{"key":"2022020920550608000_93.2.235.20","first-page":"236","article-title":"Management of severe hypotony with intravitreal injection of Healon.","volume":"28","author":"Cadera","year":"1993","journal-title":"Can J Ophthalmol"},{"key":"2022020920550608000_93.2.235.21","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.ajo.2005.06.019","article-title":"Management of severe hypotony with intravitreal injection of viscoelastic.","volume":"140","author":"Tosi","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"2022020920550608000_93.2.235.22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9394(14)76889-8","article-title":"Causes of failure after initial vitreoretinal surgery for severe proliferative vitreoretinopathy.","volume":"111","author":"Lewis","year":"1991","journal-title":"Am J Ophthalmol"},{"key":"2022020920550608000_93.2.235.23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0002-9394(14)72956-3","article-title":"Treatment of hypotonous maculopathy after trabeculectomy with mitomycin C.","volume":"118","author":"Nuyts","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"2022020920550608000_93.2.235.24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0146-2776(80)80031-0","article-title":"Inflammation and intraocular pressure after the use of Healon in intraocular lens surgery.","volume":"6","author":"Binkhorst","year":"1980","journal-title":"J Am Intraocul Implant Soc"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo.2008.143834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T04:56:03Z","timestamp":1644468963000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo.2008.143834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,1]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,1,27]]},"published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1136\/bjo.2008.143834"],"URL":"https:\/\/doi.org\/10.1136\/bjo.2008.143834","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,1]]}}}