{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:52:54Z","timestamp":1790553174925,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Aims:<\/jats:title><jats:p>The aim of the study was to conduct a preliminary clinical trial to assess whether adjunctive topical corticosteroids improve outcomes in bacterial keratitis and, if no difference was found, to determine the feasibility and sample size necessary for conducting a larger trial to answer this question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>In this single centre, double-masked clinical trial, 42 patients with culture-confirmed bacterial keratitis at Aravind Eye Hospital in India were randomised to receive either topical prednisolone phosphate or placebo. All patients received topical moxifloxacin. The primary outcome was best spectacle-corrected visual acuity (BSCVA) at 3 months, adjusting for enrolment BSCVA and arm. Other pre-specified outcomes included re-epithelialisation time, infiltrate\/scar size and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Compared with placebo, patients in the steroid group re-epithelialised more slowly (hazard ratio 0.47, 95% CI 0.23 to 0.94). There was no significant difference in BSCVA or infiltrate\/scar size at 3 weeks or 3 months. To have 80% power to detect a two-line difference in acuity, 360 cases would be required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Although corticosteroid treatment resulted in a statistically significant delay in re-epithelialisation, this did not translate to a significant difference in visual acuity, infiltrate\/scar size or adverse events. To assess the effect of steroids on acuity, a larger trial is warranted and feasible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number:<\/jats:title><jats:p>NCT00324168<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo.2008.147298","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T00:44:57Z","timestamp":1222908297000},"page":"198-202","source":"Crossref","is-referenced-by-count":54,"title":["Corticosteroids for bacterial corneal ulcers"],"prefix":"10.1136","volume":"93","author":[{"given":"M","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lalitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Mahalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N V","family":"Prajna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mascarenhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Chidambaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K C","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zegans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D V","family":"Glidden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Whitcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"Lietman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N R","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"2022020920550616000_93.2.198.1","first-page":"214","article-title":"Corneal blindness: a global perspective.","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull World Health Organ"},{"key":"2022020920550616000_93.2.198.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.079533"},{"key":"2022020920550616000_93.2.198.3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090120087027"},{"key":"2022020920550616000_93.2.198.4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0161-6420(91)32212-7","article-title":"Corticosteroids\u2014an unresolved debate.","volume":"98","author":"O\u2019Day","year":"1991","journal-title":"Ophthalmology"},{"key":"2022020920550616000_93.2.198.5","unstructured":"American Academy of Ophthalmology Cornea\/External Disease Panel. 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