{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:04:26Z","timestamp":1649149466732},"reference-count":20,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Ophthalmology"],"published-print":{"date-parts":[[1940,11,1]]},"DOI":"10.1136\/bjo.24.11.547","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:53:19Z","timestamp":1190152399000},"page":"547-559","source":"Crossref","is-referenced-by-count":1,"title":["TRACHOMA (Some experimental data with a clinical interest from the records of a combined aetiological investigation by various members of the Government Ophthalmic Hospital, and the King Institute of Preventive Medicine, Madras, 1935, 1936, 1937)"],"prefix":"10.1136","volume":"24","author":[{"given":"R. E.","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"857","author":"RAO, R.S.; PANDIT, C.G.; SHORTT, H.E.","year":"1936","unstructured":"RAO, R. S., PANDIT, C. G. and SHORTT, H. E. (1936).-Ind. JI. Med. Res., Vol. XXIII, p. 857.","journal-title":"Ind. JI. Med. Res., Vol. XXIII"},{"key":"ref_2","first-page":"865","article-title":"Virus Diseases of Man","author":"SHORTT, H.E.; S., R.A.O.R.; SWAMINATH, C.S.","year":"1936","unstructured":"SHORTT, H. E., RAO. R. S. and SWAMINATH, C. S. (1936).-bid. JI. Med. Res., Vol. XXIII, p. 865. VAN ROOYEN and RHODES (1940).-Virus Diseases of Man.","journal-title":"Med. Res., Vol. XXIII"},{"key":"ref_3","article-title":"SERIES B)-STATEMENT","volume-title":"I","unstructured":"(SERIES B)-STATEMENT I"},{"issue":"7","key":"ref_4","first-page":"12","article-title":"The conjunctival material was collected and instilled as in the 1934-3 5 experiments* but the trachoma tissue juice was added to broth and thus diluted, when collecting material for comparative unfiltered and filtered experiments","volume":"6","unstructured":"The conjunctival material was collected and instilled as in the 1934-3 5 experiments* but the trachoma tissue juice was added to broth and thus diluted, when collecting material for comparative unfiltered and filtered experiments, viz., Serial Nos. 6, 7, 8, 9, 10, 11, 12.","journal-title":"viz., Serial Nos"},{"key":"ref_5","article-title":"The earliest onset in our 1934 experiments was the fifth day","unstructured":"The earliest onset in our 1934 experiments was the fifth day."},{"key":"ref_6","first-page":"475","volume":"Vol. XXIII,","author":"of Med, Ind Ji","year":"1935","unstructured":"* Ind. Ji. of Med. Res., Vol. XXIII, pp. 475-476, October, 1935. (The cases referred to in this publication are referred to as Series A).","journal-title":"Res"},{"key":"ref_7","article-title":"SERIES B) STATEMENT I-continued Serial No. of observation","unstructured":"(SERIES B) STATEMENT I-continued Serial No. of observation."},{"key":"ref_8","article-title":"Total 13 occasions In 1934-5 Series A instillations as above resulted in transmitting the disease in every case (7 out of 7). The present series shows the fallacy of taking our previous figures at their face value, and drawing conclusions from small numbers of observations","unstructured":"+ 8-Total 13 occasions In 1934-5 Series A instillations as above resulted in transmitting the disease in every case (7 out of 7). The present series shows the fallacy of taking our previous figures at their face value, and drawing conclusions from small numbers of observations."},{"key":"ref_9","article-title":"SERIES B)-STATEMENT","author":"II","unstructured":"(SERIES B)-STATEMENT II"},{"key":"ref_10","article-title":"The conjunctival material was collected and instilled as in the 1934-5 experiments with this difference, that it was mixed with 1i-2 c.c. of broth or saline for purposes of filtration","unstructured":"The conjunctival material was collected and instilled as in the 1934-5 experiments with this difference, that it was mixed with 1i-2 c.c. of broth or saline for purposes of filtration."},{"key":"ref_11","article-title":"SERIES B)-STATEMENT III","unstructured":"(SERIES B)-STATEMENT III"},{"key":"ref_12","article-title":"SERIES B) STATEMENT III-continued","unstructured":"(SERIES B) STATEMENT III-continued"},{"key":"ref_13","article-title":"This statement shows that in four comparable experimental groups the filtered material gave negative results, whilst the unfiltered gave some positive results. In the fifth, unfiltered gave a positive. filtered a negative; but in the latter case there was a possibility of greater dilution","unstructured":"This statement shows that in four comparable experimental groups the filtered material gave negative results, whilst the unfiltered gave some positive results. In the fifth, unfiltered gave a positive. filtered a negative; but in the latter case there was a possibility of greater dilution. (Serial No. 1 above)."},{"key":"ref_14","article-title":"Without further evidence the experiments suggest that filtration (1i8, u a.p.d.) may exclude the infective agent. Thygeson and Proctor appear to have infected five sphinx baboons with material filtered through the Elford membrane of 075, u a.p.d","unstructured":"Without further evidence the experiments suggest that filtration (1i8,u a.p.d.) may exclude the infective agent. Thygeson and Proctor appear to have infected five sphinx baboons with material filtered through the Elford membrane of 075,u a.p.d."},{"issue":"8","key":"ref_15","first-page":"p","article-title":"The same dilution was employed in all cases where the filtered and unfiltered material was obtained from the same donors. Membrane filters","volume":"1","unstructured":"The same dilution was employed in all cases where the filtered and unfiltered material was obtained from the same donors. Membrane filters (Elford) of 1V8,p a.p.d. were used.","journal-title":"(Elford) of"},{"key":"ref_16","article-title":"The loss of titre on filtration might account for the negatives in the filtered series in view of the number of negatives in the unfiltered series; although a considerable loss of virus can hardly be postulated if filtration through membranes 075Iaa.p.d. allowed of positive results (see Note 2). 1935 (SERIES A and B)-STATEMENT I Effects of Heat on Unfiltered Material Unfiltered heated material from trachoma cases was instilled into the normal conjunctival sac with Negative result","unstructured":"The loss of titre on filtration might account for the negatives in the filtered series in view of the number of negatives in the unfiltered series; although a considerable loss of virus can hardly be postulated if filtration through membranes 075Iaa.p.d. allowed of positive results (see Note 2). 1935 (SERIES A and B)-STATEMENT I Effects of Heat on Unfiltered Material Unfiltered heated material from trachoma cases was instilled into the normal conjunctival sac with Negative result."},{"key":"ref_17","article-title":"Conjunctival material was collected and instilled as in 1934-35 experiments","unstructured":"Conjunctival material was collected and instilled as in 1934-35 experiments."},{"key":"ref_18","article-title":"This case is recorded in Series A 1935, and must not be included in the totals","author":"of Series B, C, and D","unstructured":"+ This case is recorded in Series A 1935, and must not be included in the totals of Series B, C, and D."},{"key":"ref_19","article-title":"SERIES C)-STATEMENT","volume-title":"I","unstructured":"(SERIES C)-STATEMENT I"},{"key":"ref_20","article-title":"Supplementary to Statement III","volume":"1935","unstructured":"(Supplementary to Statement III, Series B, 1935)","journal-title":"Series B"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo.24.11.547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T19:47:29Z","timestamp":1601063249000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo.24.11.547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1940,11,1]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1940,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/bjo.24.11.547","relation":{},"ISSN":["0007-1161"],"issn-type":[{"value":"0007-1161","type":"print"}],"subject":[],"published":{"date-parts":[[1940,11,1]]}}}