{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T20:22:01Z","timestamp":1725394921473},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Ophthalmology"],"published-print":{"date-parts":[[1984,4,1]]},"DOI":"10.1136\/bjo.68.4.245","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:53:19Z","timestamp":1190152399000},"page":"245-247","source":"Crossref","is-referenced-by-count":10,"title":["Binding potencies of 3 new beta 2 specific blockers to beta receptors in the ciliary processes and the possible relevance of these drugs to intraocular pressure control."],"prefix":"10.1136","volume":"68","author":[{"given":"G E","family":"Trope","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"788","article-title":"Bela adrencrgic reccptors in pigmcnted ciliary processcs","volume":"66","author":"Tropc, G.E.; Clairk, B.","year":"1982","unstructured":"Tropc GE, Clairk B. Bela adrencrgic reccptors in pigmcnted ciliary processcs. BrJ Ophtilialnol 1982; 66: 788-92.","journal-title":"BrJ Ophtilialnol"},{"key":"ref_2","first-page":"798","article-title":"Human cilialry proccsscs aidrcncrgic reccptors: pharmacologiceil characterisation. Invest Ophthalmnol Visu(al Sci with heart disease, and to reduce resting heart rate","volume":"202","author":"Nathanson, J.A.","year":"1981","unstructured":"Nathanson JA. Human cilialry proccsscs aidrcncrgic reccptors: pharmacologiceil characterisation. Invest Ophthalmnol Visu(al Sci with heart disease, and to reduce resting heart rate 1981; 202: 798-8()4."},{"issue":"1","key":"ref_3","first-page":"18","article-title":"Adrcncrgic rcccptors in main","volume":"301","author":"Motulsky, H.J.; Inscl, P.A.","year":"1982","unstructured":"Motulsky HJ, Inscl PA. Adrcncrgic rcccptors in main. N kEig J Med 1982;301: 1, 18-29.","journal-title":"N kEig J Med"},{"issue":"3","key":"ref_4","first-page":"5","article-title":"If this is so, specific 1, blockers should produce the same effect; Further studies to determine whether 1 receptors exist in uveal vasculature seems to be aidrcnergic reccptor subtypcs in mammalian tissuc","volume":"211","year":"1979","unstructured":"If this is so, specific 1, blockers should produce the same effect; Further studies to determine whether 1 receptors exist in uveal vasculature seems to be aidrcnergic reccptor subtypcs in mammalian tissuc. J Pharmnacol Exp Tl\/er 1979; 211: 3, 5(2-8.","journal-title":"J Pharmnacol Exp Tl\/er"},{"key":"ref_5","first-page":"367","article-title":"Fundamentals of biochemical pharmacology","author":"In, Wcnke M.; ZM, Bacq; cd","year":"1971","unstructured":"Wcnke M. In: Bacq ZM, cd. Fundamentals of biochemical pharmacology Oxford: Pcrgamon Prcss, 1971; 367-40)9."},{"key":"ref_6","first-page":"97","article-title":"Effccts ofaI potent ncw aidrcnorcccptor aintaigonist","volume":"73","author":"Nathanson, J.A.","year":"1981","unstructured":"Nathanson JA. Effccts ofaI potent ncw aidrcnorcccptor aintaigonist on l. O. P. Br J Pharmacol 1981; 73: 97-1 (X). 12 Van Buskirk EM. Advcrsc rcactionsfrom timolol addministraition.","journal-title":"Br J Pharmacol; X). 12 Van Buskirk EM. Advcrsc rcactionsfrom timolol addministraition"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/bjo.63.1.63","article-title":"Oculair aind cardiovaisculair cffccts of local aind systcmic pindolol","volume":"63","author":"Smith, S.E.; Smith, S.A.; Rcynolds, F.; Whitmarsh, V.B.","year":"1979","unstructured":"Smith SE, Smith SA, Rcynolds F, Whitmarsh, VB. Oculair aind cardiovaisculair cffccts of local aind systcmic pindolol. Br J Ophthaltnol 1979; 63: 63-6.","journal-title":"Br J Ophthaltnol"},{"key":"ref_8","first-page":"586","article-title":"Effects in man of ICII 18.551 (a scicctivc li, aidrcnorcccptor blocking drug) on topical application of betaxolol could therefore block both 1, receptors and any 13 receptors that may exist in human ciliary processes. Radioligand binding studies of this drug, preferably on primate or human somc cardiovascular rcsponscs induced by isoprcnallinc","volume":"13","author":"Fitzgeraild, D.; Gumbriclc, J.; Ilairry, J.D.","year":"1982","unstructured":"Fitzgeraild D, Gumbriclc J, Ilairry JD. Effects in man of ICII 18.551 (a scicctivc li, aidrcnorcccptor blocking drug) on topical application of betaxolol could therefore block both 1, receptors and any 13 receptors that may exist in human ciliary processes. Radioligand binding studies of this drug, preferably on primate or human somc cardiovascular rcsponscs induced by isoprcnallinc. BrJ C\/in Phlarmnacaol 1982; 13: 586.","journal-title":"BrJ C\/in Phlarmnacaol"},{"key":"ref_9","first-page":"67","article-title":"Choroidal blood flow-thc cffccts of autonomic aigents","volume":"87","author":"Chandra, SR, Friedman; E.","year":"1972","unstructured":"Chandra SR, Friedman E. Choroidal blood flow-thc cffccts of autonomic aigents. Arc\/h Opithahnol 1972; 87: 67-9.","journal-title":"Arc\/h Opithahnol"},{"issue":"3","key":"ref_10","first-page":"164","article-title":"The spccificity and vaisculair eyes, are indicated. It has recently been suggested that the pigmented layer of the ciliary processes may act as a depot for topically applied 13 blockers. This may lead to their mcchanisms of timolol","volume":"16","author":"Langham, M.E.; Craigic, B.","year":"1979","unstructured":"Langham ME, Craigic B. The spccificity and vaisculair eyes, are indicated. It has recently been suggested that the pigmented layer of the ciliary processes may act as a depot for topically applied 13 blockers. This may lead to their mcchanisms of timolol. ARVOAbbsir 1979; 16: 3: 164.","journal-title":"ARVOAbbsir"},{"key":"ref_11","first-page":"133","article-title":"Adrcncrgic phairmocology of aqucous humor dynamics Pharmacol Rcv","volume":"3","author":"Potter, D.E.","year":"1981","unstructured":"Potter DE. Adrcncrgic phairmocology of aqucous humor dynamics Pharmacol Rcv 1981; 3: 133-53."},{"key":"ref_12","first-page":"943","article-title":"Bctaxolol-aI new betai adrencrgic blocking agent for treatmcnt of glaucoma. Arch Ophthialmnol sustained release to ciliary process 1 receptors.2'","volume-title":"is an interesting theory, as we have noted that melanin derived from the ciliary processes binds radioactive ligand potently.5 Part","volume":"100","author":"Berrospi, A.R.; Lcibowitz, H.M.","year":"1982","unstructured":"Berrospi AR, Lcibowitz HM. Bctaxolol-aI new betai adrencrgic blocking agent for treatmcnt of glaucoma. Arch Ophthialmnol sustained release to ciliary process 1 receptors.2' This 1982; 100: 943-6. is an interesting theory, as we have noted that melanin derived from the ciliary processes binds radioactive ligand potently.5 Part of this binding is probably due"},{"key":"ref_13","first-page":"113","article-title":"Rcccptor mcchainisms for cpinephrinc and timolol","volume-title":"cd. Basic aspects of glaiucoan(i","author":"Ncufeld, A.H.; Bartcls, S.P.","year":"1982","unstructured":"Ncufeld AH, Bartcls SP. Rcccptor mcchainisms for cpinephrinc and timolol. In: Lutten E, cd. Basic aspects of glaiucoan(i. Stuttgart: Schattaucr, 1982: 113-22."}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T23:05:18Z","timestamp":1601075118000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo.68.4.245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4,1]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/bjo.68.4.245","relation":{},"ISSN":["0007-1161"],"issn-type":[{"value":"0007-1161","type":"print"}],"subject":[],"published":{"date-parts":[[1984,4,1]]}}}