{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:48:28Z","timestamp":1791960508942,"version":"4.3.4"},"reference-count":25,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Ophthalmology"],"published-print":{"date-parts":[[1989,4,1]]},"DOI":"10.1136\/bjo.73.4.255","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:53:19Z","timestamp":1190152399000},"page":"255-260","source":"Crossref","is-referenced-by-count":15,"title":["Does vitreous fluorophotometry reflect severity of early diabetic retinopathy?"],"prefix":"10.1136","volume":"73","author":[{"given":"W E","family":"Plehwe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Sleightholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Kohner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1113\/jphysiol.1967.sp008262","article-title":"The active transport of fluorescein by the retinal vessles and retina","volume":"191","author":"Cunha-Vaz, J.G.; Maurice, D.M.","year":"1967","unstructured":"Cunha-Vaz JG, Maurice DM. The active transport of fluorescein by the retinal vessles and retina. J Physiol (Lond) 1967; 191: 467-86.","journal-title":"J Physiol (Lond)"},{"issue":"649-56","key":"ref_2","first-page":"3","article-title":"Early breakdown of the blood-retinal barrier in diabetes","volume":"59","author":"Cunha-Vaz, J.G.; De Abreu, J.R.F.; Campos, A.J.; Figo, G.","year":"1975","unstructured":"Cunha-Vaz JG, De Abreu JRF, Campos AJ, Figo G. Early breakdown of the blood-retinal barrier in diabetes. Br J Ophthalmol 1975; 59: 649-56. 3 Cunha-Vaz JG, Fonseca JR, Abreu JF, Ruas MA. A follow-up study by vitreous fluorophotometry of early retinal involvement in diabetes. Am J Ophthalmol 1978; 86: 467-73.","journal-title":"Br J Ophthalmol; Ruas MA. A follow-up study by vitreous fluorophotometry of early retinal involvement in diabetes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2337\/diab.27.2.85","article-title":"Quantitative vitreous fluorophotometry. A sensitive technique for measuring early breakdown of the blood-retinal barrier in young diabetic patients","volume":"27","author":"Waltman, SR, Oestrich; C, Krupin; T.","year":"1978","unstructured":"Waltman SR, Oestrich C, Krupin T, et al. Quantitative vitreous fluorophotometry. A sensitive technique for measuring early breakdown of the blood-retinal barrier in young diabetic patients. Diabetes 1978; 27: 85-7.","journal-title":"Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2337\/diabetes.28.1.16","article-title":"Detection of early retinal changes in diabetes by vitreous fluorophotometry","volume":"28","author":"Cunha-Vaz, J.G.; Fonseca, JR, Abreu; JF, Ruas; M.A.","year":"1979","unstructured":"Cunha-Vaz JG, Fonseca JR, Abreu JF, Ruas MA. Detection of early retinal changes in diabetes by vitreous fluorophotometry. Diabetes 1979; 28: 16-9.","journal-title":"Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1001\/archopht.1978.03910050418002","article-title":"Vitreous fluorophotometry in juvenile-onset diabetes mellitus","volume":"96","author":"Krupin, T.; Waltman, SR, Oestrich; C.","year":"1978","unstructured":"Krupin T, Waltman SR, Oestrich C, et al. Vitreous fluorophotometry in juvenile-onset diabetes mellitus. Arch Ophthalmol 1978; 96: 812-4.","journal-title":"Arch Ophthalmol"},{"key":"ref_6","first-page":"597","article-title":"Evidence for functional endothelial cell damage in early diabetic retinopathy","volume":"20","author":"Porta, M.; Townsend, C.; CloverJM","year":"1981","unstructured":"Porta M, Townsend C, CloverJM, et al. Evidence for functional endothelial cell damage in early diabetic retinopathy. Diabetologia 1981; 20: 597-601.","journal-title":"Diabetologia"},{"key":"ref_7","first-page":"703","article-title":"Vitreous fluorophotometric evaluation of diabetics","volume":"25","author":"Bursell, S.E.; Delori, F.C.; Yoshida, A.; Parker, J.S.; Collas, G.D.; McMeel, J.W.","year":"1984","unstructured":"Bursell SE, Delori FC, Yoshida A, Parker JS, Collas GD, McMeel JW. Vitreous fluorophotometric evaluation of diabetics. Invest Ophthalmol Vis Sci 1984; 25: 703-10.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2337\/diacare.9.2.134","article-title":"Vitreous fluorophotometry in patients with no or minimal retinopathy","volume":"9","author":"Chahal, P.; Fallon, T.J.; Jennings, S.J.; Chowienczyk, P.J.; Kohner, E.M.","year":"1986","unstructured":"Chahal P, Fallon TJ, Jennings SJ, Chowienczyk PJ, Kohner EM. Vitreous fluorophotometry in patients with no or minimal retinopathy. Diabetes Care 1986; 9: 134-9.","journal-title":"Diabetes Care"},{"key":"ref_9","first-page":"200","article-title":"Effect of one year of near-normal blood-glucose levels on retinopathy in insulin-dependent diabetes","volume":"i:","author":"Lauritzen, T.; Frost-Larsen, K.; Larsen, H.-W.; Deckert, T.; Group, Steno Study","year":"1983","unstructured":"Lauritzen T, Frost-Larsen K, Larsen H-W, Deckert T, Steno Study Group. Effect of one year of near-normal blood-glucose levels on retinopathy in insulin-dependent diabetes. Lancet 1983; i:200-4.","journal-title":"Lancet"},{"key":"ref_10","first-page":"811","article-title":"Aagenaes 0, Aker Diabetes Group. Rapid tightening of blood glucose control leads to transient deterioration in retinopathy in insulin-dependent diabetes mellitus","volume":"290","year":"1985","unstructured":"Dahl-Jorgensen K, Brinchmann-Hansen 0, Hansen KF, Sandvik L, Aagenaes 0, Aker Diabetes Group. Rapid tightening of blood glucose control leads to transient deterioration in retinopathy in insulin-dependent diabetes mellitus. The Oslo Study. Br Med J 1985; 290: 811-5.","journal-title":"The Oslo Study. Br Med J"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198408093110604","article-title":"Blood glucose control and the evolution of diabetic retinopathy and albuminuria","volume":"311","author":"Group, Kroc Collaborative Study","year":"1985","unstructured":"Kroc Collaborative Study Group. Blood glucose control and the evolution of diabetic retinopathy and albuminuria. N Engl J Med 1985; 311:365-72.","journal-title":"N Engl J Med"},{"key":"ref_12","first-page":"210","article-title":"Diabetic Retinopathy Study Research Group. Report 7. A modification of the Airlie House classification of diabetic retinopathy","volume":"21","year":"1981","unstructured":"Diabetic Retinopathy Study Research Group. Report 7. A modification of the Airlie House classification of diabetic retinopathy. Invest Ophthalmol Vis Sci 1981; 21: 210-6.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0161-6420(84)34336-6","article-title":"Diabetic retinopathy. Assessment of severity and progression","volume":"91","author":"Klein, B.E.K.; Davis, M.D.; Segal, P.","year":"1984","unstructured":"Klein BEK, Davis MD, Segal P, et al. Diabetic retinopathy. Assessment of severity and progression. Ophthalmology 1984; 91:10-7.","journal-title":"Ophthalmology"},{"issue":"3","key":"ref_14","first-page":"50","article-title":"Comparison of stereo fundus photographs in patients with insulin-dependent diabetes during conventional insulin treatment or continuous subcutaneous insulin infusion","volume":"34","author":"Canny, C.L.B.; Kohner, E.M.; Trautman, J.; Puklin, J.; for the Kroc Collaborative Study Group, Morse P.","year":"1985","unstructured":"Canny CLB, Kohner EM, Trautman J, Puklin J, Morse P for the Kroc Collaborative Study Group. Comparison of stereo fundus photographs in patients with insulin-dependent diabetes during conventional insulin treatment or continuous subcutaneous insulin infusion. Diabetes 1985; 34 (suppl 3): 50-5.","journal-title":"Diabetes"},{"key":"ref_15","first-page":"977","article-title":"Measurement of blood-retinal barrier permeability: a reproducibility study in normal eyes","volume":"26","author":"Chahal, P.S.; Chowienczyk, P.J.; Kohner, E.M.","year":"1985","unstructured":"Chahal PS, Chowienczyk PJ, Kohner EM. Measurement of blood-retinal barrier permeability: a reproducibility study in normal eyes. Invest Ophthalmol Vis Sci 1985; 26: 977-82.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_16","first-page":"764","article-title":"Metabolism of fluorescein after intravenous injection","volume":"26","author":"Chahal, P.S.; Neal, M.J.; Kohner, E.M.","year":"1985","unstructured":"Chahal PS, Neal MJ, Kohner EM. Metabolism of fluorescein after intravenous injection. Invest Ophthalmol Vis Sci 1985; 26: 764-8.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-4835(85)90105-8","article-title":"Fluorescent, physiological and pharmacological properties of fluorescein glucuronide","volume":"40","author":"Grotte, D.; Mattox, V.; Brubaker, R.F.","year":"1985","unstructured":"Grotte D, Mattox V, Brubaker RF. Fluorescent, physiological and pharmacological properties of fluorescein glucuronide. Exp Eye Res 1985; 40: 23-34.","journal-title":"Exp Eye Res"},{"key":"ref_18","first-page":"966","article-title":"Measurement of fluorescein and fluorescein glucuronide in the living human eye","volume":"27","author":"McLaren, J.W.; Brubaker, R.F.","year":"1986","unstructured":"McLaren JW, Brubaker RF. Measurement of fluorescein and fluorescein glucuronide in the living human eye. Invest Ophthalmol Vis Sci 1986; 27: 966-74.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_19","first-page":"998","article-title":"Transport of fluorescein monoglucuronide out of the vitreous","volume":"27","author":"Kitano, S.; Nagataki, S.","year":"1986","unstructured":"Kitano S, Nagataki S. Transport of fluorescein monoglucuronide out of the vitreous. Invest Ophthalmol Vis Sci 1986; 27: 998-1001.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-4835(87)80005-2","article-title":"Role of fluorescein glucuronide and its metabolism in vitreous fluorophotometry","volume":"44","author":"Plehwe, W.E.; Chahal, P.S.; Fallon, T.J.; Cunningham, JR, Neal; MJ, Kohner; E.M.","year":"1987","unstructured":"Plehwe WE, Chahal PS, Fallon TJ, Cunningham JR, Neal MJ, Kohner EM. Role of fluorescein glucuronide and its metabolism in vitreous fluorophotometry. Exp Eye Res 1987; 44: 209-15.","journal-title":"Exp Eye Res"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1001\/archopht.1986.01050190062040","article-title":"Posterior vitreous fluorophotometry in normal subjects","volume":"104","author":"Roy, M.S.; Bonner, R.F.; Bungay, P.M.; Podgor, M.J.; Collier, B.","year":"1986","unstructured":"Roy MS, Bonner RF, Bungay PM, Podgor MJ, Collier B. Posterior vitreous fluorophotometry in normal subjects. Arch Ophthalmol 1986; 104: 1004-8.","journal-title":"Arch Ophthalmol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/archopht.1987.01060020072032","article-title":"Quantification of diabetic macular edema","volume":"105","author":"Smith, R.T.; Lee, C.M.; Charles, H.C.; Farber, M.; Cunha-Vaz, J.G.","year":"1987","unstructured":"Smith RT, Lee CM, Charles HC, Farber M, Cunha-Vaz JG. Quantification of diabetic macular edema. Arch Ophthalmol 1987; 105: 218-22.","journal-title":"Arch Ophthalmol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/bjo.66.12.762","article-title":"Continuous subcutaneous insulin infusion does not prevent progression of proliferative and preproliferative retinopathy","volume":"66","author":"Lawson, P.M.; Champion, M.C.; Canny, C.L.B.","year":"1982","unstructured":"Lawson PM, Champion MC, Canny CLB, et al. Continuous subcutaneous insulin infusion does not prevent progression of proliferative and preproliferative retinopathy. Br J Ophthalmol 1982; 66: 762-6.","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"ref_24","first-page":"74","article-title":"Two-year experience with continuous subcutaneous insulin infusion in relation to retinopathy and neuropathy","volume":"35","author":"Lauritzen, T.; Frost-Larsen, K.; Larsen, H.-W.; Group, Deckert T.Steno Study","year":"1985","unstructured":"Lauritzen T, Frost-Larsen K, Larsen H-W, Deckert T. Steno Study Group. Two-year experience with continuous subcutaneous insulin infusion in relation to retinopathy and neuropathy. Diabetes 1985; 35 (suppl 3): 74-9.","journal-title":"Diabetes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/BF00870275","article-title":"Diabetic control and diabetic complications: the near-normoglycaemic experience","volume":"29","author":"Deckert, T.","year":"1986","unstructured":"Deckert T. Diabetic control and diabetic complications: the near-normoglycaemic experience. Diabetologia 1986; 29: 677-84.","journal-title":"Diabetologia"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T23:13:19Z","timestamp":1601075599000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo.73.4.255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/bjo.73.4.255","relation":{},"ISSN":["0007-1161"],"issn-type":[{"value":"0007-1161","type":"print"}],"subject":[],"published":{"date-parts":[[1989,4,1]]}}}