{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:12:34Z","timestamp":1790190754694,"version":"4.1.0"},"reference-count":15,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2016,10,24]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the vessel calibre measurements between optical coherence tomography angiography (OCTA) and colour fundus photography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective comparative study, OCTA and colour fundus images of healthy eyes and eyes with optic atrophy were evaluated. The colour fundus image was registered manually using Image J software to the OCTA image of the optic disc. Two independent graders measured the vessel calibre of the widest vein and artery in each peripapillary quadrant on a 3.4\u2005mm diameter circle centred on the optic disc in the same location on both images. The difference in vessel calibre between the two techniques was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 312 vessels from 29 healthy eyes and 20 eyes with atrophic optic discs were included. There was a high level of agreement between graders for measurement of vessel calibre in both colour fundus (intraclass correlation coefficient=0.93, coefficient of variation=0.07) and OCTA images (intraclass correlation coefficient=0.94, coefficient of variation=0.05). The mean vessel calibre in colour fundus images (94.5\u00b123.2\u2005\u00b5m) and OCT images (112.2\u00b126.1\u2005\u00b5m) was correlated (r=0.8, p&lt;0.001), but the difference was statistically significant (mean difference: 17.6\u00b11.5\u2005\u00b5m, p&lt;0.001). This difference was evident for both arteries (mean difference: 18.2\u00b116.3\u2005\u00b5m, p&lt;0.001) and veins (mean difference: 15.1\u00b116.2\u2005\u00b5m, p&lt;0.001) individually, with a similar magnitude of difference for both vessel types (p=0.08). In addition, the magnitude of difference between imaging modalities was similar in atrophic and healthy discs (17.1\u00b115.9 vs 18.4\u00b115.2\u2005\u00b5m, respectively, p=0.4). The difference, however, was significantly higher in vessels with a calibre of \u226494.5 compared with larger vessels (19.3\u00b116.3 vs 15.6\u00b114.4\u2005\u00b5m, respectively, p=0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vessel calibre measurements were significantly larger in OCTA images compared with colour fundus photographs, particularly for smaller vessels. These differences may need to be accounted for when using OCTA-derived metrics.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjophthalmol-2016-309678","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T01:23:54Z","timestamp":1479345834000},"page":"989-992","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Retinal vessel calibre measurements by optical coherence tomography angiography"],"prefix":"10.1136","volume":"101","author":[{"given":"Khalil","family":"Ghasemi Falavarjani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayss","family":"Al-Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Darvizeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A","family":"Sadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas R","family":"Sadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"2024092603303463000_101.7.989.1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.180709"},{"key":"2024092603303463000_101.7.989.2","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-015-0005-8"},{"key":"2024092603303463000_101.7.989.3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000765"},{"key":"2024092603303463000_101.7.989.4","doi-asserted-by":"crossref","unstructured":"Ghasemi Falavarjani K , Al-Sheikh M , Akil H , et al . 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