{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T21:34:15Z","timestamp":1794605655004,"version":"4.9.1"},"reference-count":20,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFC1000307"],"award-info":[{"award-number":["2016YFC1000307"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"national science and technology basic work","award":["2014FY130100"],"award-info":[{"award-number":["2014FY130100"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of ocular abnormalities of newborn in China has seldom been reported. To report the implementation of digital imaging in ocular screening of all newborns in multiple centres in China and to describe the abnormal findings of fundus examination, we did the cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fundus examinations were performed on newborns within the 42 days after birth using a RetCam wide-field digital imaging system. Digital images of the posterior pole, superior, nasal and temporal retinal fields of each participant were taken. All newborns were from eights centres across China from January 2009 to July 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 199\u2009851 newborns were included in the study. We detected 18\u2009198 (9.11%) abnormal cases. The most frequent abnormality was severe retinal haemorrhage (RH) found in 12\u2009810 cases (6.41%). The other anomalies included familial exudative vitreoretinopathy, retinopathy of prematurity, abnormal fundus pigmentation, subconjunctival haemorrhage, choroidal coloboma, idiopathic retinal venous tortuosity, exudative changes and other anomalies with uncertain identities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large-scale study of newborn fundus examination showed a relatively high prevalence of ocular abnormalities. Hundreds of neonates with rare disorders that severely impair ocular health were also detected at an early age. The long-term impact of other anomalies including RHs on the ocular system should be investigated by a perspective study. Our study suggested that fundus examination of newborns can play a beneficial role in ocular health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjophthalmol-2018-312366","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T12:16:14Z","timestamp":1534508174000},"page":"1742-1746","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Fundus examination of 199 851 newborns by digital imaging in China: a multicentre cross-sectional study"],"prefix":"10.1136","volume":"102","author":[{"given":"He","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiju","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changbing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manxiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of The collaborating group of neonatal ocular birth defects and genetic diseases in China","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"2020050713002016000_102.12.1742.1","doi-asserted-by":"publisher","DOI":"10.1076\/opep.6.1.73.1571"},{"key":"2020050713002016000_102.12.1742.2","first-page":"469","article-title":"Outcomes of 957 preterm neonatal fundus examinations in a Guangzhou NICU through 2008 to 2011","volume":"5","author":"Ju","year":"2012","journal-title":"Int J Ophthalmol"},{"key":"2020050713002016000_102.12.1742.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2624"},{"key":"2020050713002016000_102.12.1742.4","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306215"},{"key":"2020050713002016000_102.12.1742.5","first-page":"259","article-title":"The red reflex examination in neonates: an efficient tool for early diagnosis of congenital ocular diseases","volume":"12","author":"Eventov-Friedman","year":"2010","journal-title":"Isr Med Assoc J"},{"key":"2020050713002016000_102.12.1742.6","first-page":"697","article-title":"The evaluation of red reflex sensitivity and specificity test among neonates in different conditions","volume":"24","author":"Mussavi","year":"2014","journal-title":"Iran J Pediatr"},{"key":"2020050713002016000_102.12.1742.7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1590\/S0104-11692011000200012","article-title":"Association of the red reflex in newborns with neonatal variables","volume":"19","author":"de Aguiar","year":"2011","journal-title":"Rev Lat Am Enfermagem"},{"key":"2020050713002016000_102.12.1742.8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpeds.2016.08.048","article-title":"Sensitivity and specificity of red reflex test in newborn eye screening","volume":"179","author":"Sun","year":"2016","journal-title":"J Pediatr"},{"key":"2020050713002016000_102.12.1742.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0882"},{"key":"2020050713002016000_102.12.1742.10","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90099-7"},{"key":"2020050713002016000_102.12.1742.11","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302539"},{"key":"2020050713002016000_102.12.1742.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2005.11.019"},{"key":"2020050713002016000_102.12.1742.13","first-page":"268","article-title":"Screening for retinopathy of prematurity employing the retcam 120: sensitivity and specificity","volume":"119","author":"Roth","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"2020050713002016000_102.12.1742.14","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12297"},{"key":"2020050713002016000_102.12.1742.15","doi-asserted-by":"crossref","first-page":"e372","DOI":"10.1111\/aos.12685","article-title":"Universal ocular screening of 1021 term infants using wide-field digital imaging in a single public hospital in India - a pilot study","volume":"93","author":"Vinekar","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"2020050713002016000_102.12.1742.16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3928\/01913913-20050701-01","article-title":"Lack of efficacy of dilated screening for retinoblastoma","volume":"42","author":"Khan","year":"2005","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"2020050713002016000_102.12.1742.17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/ojo.OJO_141_2016","article-title":"Retinopathy of prematurity like retinopathy in full-term infants","volume":"10","author":"Ratra","year":"2017","journal-title":"Oman J Ophthalmol"},{"key":"2020050713002016000_102.12.1742.18","doi-asserted-by":"publisher","DOI":"10.1038\/ng957"},{"key":"2020050713002016000_102.12.1742.19","doi-asserted-by":"crossref","unstructured":"Musada GR , Syed H , Jalali S , et al . Mutation spectrum of the FZD-4, TSPAN12 AND ZNF408 genes in Indian FEVR patients. BMC Ophthalmol 2016;16:90.doi:10.1186\/s12886-016-0236-y","DOI":"10.1186\/s12886-016-0236-y"},{"key":"2020050713002016000_102.12.1742.20","first-page":"323","article-title":"Familial exudative vitreoretinopathy (FEVR). Clinical profile and management","volume":"51","author":"Shukla","year":"2003","journal-title":"Indian J Ophthalmol"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjophthalmol-2018-312366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T04:58:00Z","timestamp":1601096280000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjophthalmol-2018-312366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,17]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,11,22]]},"published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1136\/bjophthalmol-2018-312366"],"URL":"https:\/\/doi.org\/10.1136\/bjophthalmol-2018-312366","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,17]]}}}