{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:29:58Z","timestamp":1740133798645,"version":"3.37.3"},"reference-count":35,"publisher":"BMJ","issue":"4","funder":[{"name":"the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government"},{"name":"JSPS Core-to-Core Program, A. Advanced Research Networks"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013M3A9D5072551"],"award-info":[{"award-number":["NRF-2013M3A9D5072551"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background\/aims<\/jats:title><jats:p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS\/TEN (CM-SJS\/TEN) with severe ocular complications (SOC) in the Korean population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre case-control study enrolled 40 Korean patients with CM-SJS\/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\u00a0<\/jats:title><jats:p>The carrier frequency and gene frequency of HLA-A*02:06 were 37.5 % and 20.0 %, respectively, in patients, and 16.7 % and 9.6 %, respectively, in controls (p=0.018). The carrier frequency of HLA-C*03:04 was 30 % in patients and 10.8 % in controls, and gene frequency of HLA-C*03:04 was 15 % in patients and 5.4 % in controls (p=0.003). The carrier frequency and gene frequency of HLA-C*03:03 were 2.5 % and 1.3 %, respectively, in patients, and 20 % and 10.4 %, respectively, in controls (p=0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\u00a0<\/jats:title><jats:p>As per our results, we suggest that HLA-A*02:06 and HLA-C*03:04 might be positive markers for CM-SJS\/TEN with SOC, and HLA-C*03:03 might be an indicator of protection against CM-SJS\/TEN with SOC in the Korean population.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjophthalmol-2018-313263","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T22:24:38Z","timestamp":1548973478000},"page":"573-576","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population"],"prefix":"10.1136","volume":"103","author":[{"given":"Ikhyun","family":"Jun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Hoon","family":"Rim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee Kum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Chul","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choun-Ki","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Yul","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"2023050800351120000_103.4.573.1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jtos.2015.10.002","article-title":"Stevens-Johnson syndrome\/toxic epidermal necrolysis--a comprehensive review and guide to therapy. 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