{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:15:06Z","timestamp":1789611306008,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Sports Med"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p>A few studies on small patient series have investigated the relationship between gastroesophageal reflux and bronchial responsiveness as expressed by exercise-induced bronchoconstriction (EIB), with non-conclusive results. The aim of this study was to evaluate whether the presence of acid in the oesophagus may influence EIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>45 patients with bronchial asthma underwent spirometry, exercise challenge on bicycle ergometer and 24 h oesophageal pH monitoring. Subjects with EIB (Forced expiratory volume in the first second (FEV1)) percentage decrease after exercise (\u0394FEV1) \u2a7e15%, n \u200a=\u200a 28) were retested after a 2 week treatment course with omeprazole 40 mg\/daily. Exercise at baseline was performed at the same time as oesophageal pH monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In basal condition, there was no difference in FEV1, acid exposure time or number of refluxes measured during 24 h pH monitoring between patients with and without EIB. There was no relationship between spirometry results and \u0394FEV1 on one hand, and parameters of gastroesophageal reflux on the other. Nine patients with EIB (31.0%) and six patients without EIB (37.5%) had one or more episodes of GER during exercise challenge, without significant differences between the two groups. After gastric acid inhibition by omeprazole, \u0394FEV1 did not change significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The results indicate that acid in the oesophagus, or its short-term inhibition by proton pump inhibitors, has no influence on exercise-induced bronchoconstriction.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjsm.2006.034983","type":"journal-article","created":{"date-parts":[[2007,6,2]],"date-time":"2007-06-02T01:04:40Z","timestamp":1180746280000},"page":"845-849","source":"Crossref","is-referenced-by-count":3,"title":["Acid reflux into the oesophagus does not influence exercise-induced airway narrowing in bronchial asthma"],"prefix":"10.1136","volume":"42","author":[{"given":"M","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Bonella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Benini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"De Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Testi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Lo Cascio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"2024051313050819000_42.10.845.1","first-page":"645","article-title":"Gastroesophageal reflux and chronic respiratory diseases.","volume":"129","author":"Allen","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"2024051313050819000_42.10.845.2","first-page":"327","article-title":"Gastroesophageal reflux in patients with asthma and chronic bronchitis.","volume":"135","author":"Ducolone","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"2024051313050819000_42.10.845.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70360-X"},{"key":"2024051313050819000_42.10.845.4","first-page":"224","article-title":"Gastro-oesophageal reflux and asthma: a possible reflex mechanism.","volume":"41","author":"Mansfield","year":"1978","journal-title":"Ann Allergy"},{"key":"2024051313050819000_42.10.845.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.2.201"},{"key":"2024051313050819000_42.10.845.6","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(75)90053-4"},{"key":"2024051313050819000_42.10.845.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301907"},{"key":"2024051313050819000_42.10.845.8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1152\/jappl.1979.46.3.476","article-title":"Hyperpnea and heat flux: initial reaction sequence in exercise-induced asthma.","volume":"46","author":"Deal","year":"1979","journal-title":"J Appl Physiol"},{"key":"2024051313050819000_42.10.845.9","first-page":"49","article-title":"Inflammatory mediators and asthma.","volume":"40","author":"Barnes","year":"1988","journal-title":"Pharmacol Rev"},{"key":"2024051313050819000_42.10.845.10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.7326\/0003-4819-110-1-66","article-title":"Esophageal chest pain: current controversies in pathogenesis, diagnosis, and therapy.","volume":"110","author":"Richter","year":"1989","journal-title":"Ann Intern Med"},{"key":"2024051313050819000_42.10.845.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6585.1459"},{"key":"2024051313050819000_42.10.845.12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00000658-198210000-00013","article-title":"Esophageal function in patients with angina-type chest pain and normal coronary artery angiograms.","volume":"196","author":"DeMeester","year":"1982","journal-title":"Ann Surg"},{"key":"2024051313050819000_42.10.845.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420240113036"},{"key":"2024051313050819000_42.10.845.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF02091531"},{"key":"2024051313050819000_42.10.845.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90357-2"},{"key":"2024051313050819000_42.10.845.16","unstructured":"National Health Lung and Blood Institute. 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