{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:31:55Z","timestamp":1759530715564},"reference-count":58,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Sports Med"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>Regular physical activity is associated with a reduction of cardiovascular morbidity and mortality; however, evidence of unfortunate cardiovascular events accompanying elite sport involvement continues to accumulate. To date, no information is available on possible peculiarities of the cardiovascular risk profile in athletes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>The aim of this study was to evaluate plasma homocysteine levels in a group of athletes and to search for relationship with vitamin status and other metabolic variables in order to confirm the existence of a \u201csport-related hyperhomocysteinaemia\u201d and to explain its clinical significance.<\/jats:p><jats:p>The study population was composed of 82 athletes (59 male and 23 female) practising different sports and 70 healthy age-matched subjects (40 male and 30 female) as a control group. Besides the general clinical and analytical determinations, the assessed variables included homocysteine, folate, vitamin B12, total and high-density lipoprotein (HDL) cholesterol, lactate dehydrogenase (LDH), creatine kinase (CPK) and interleukin-6 (IL-6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The prevalence of hyperhomocysteinaemia (&gt;15 \u03bcmol\/l) in athletes and controls was 47% and 15%, respectively. No correlation was found between homocysteine and any of the other investigated variables, in particular plasma folate, blood pressure, LDH, CPK, total and HDL cholesterol and IL-6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The results of this study confirm the existence of a sport-related hyperhomocysteinaemia which appears linked neither to the same variables found in the general population, nor to specific training-related variables. We suggest that it would represent an adaptation to training but the possibility of a secondary vascular damage cannot be excluded.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjsm.2007.045021","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T01:37:28Z","timestamp":1201138648000},"page":"894-900","source":"Crossref","is-referenced-by-count":15,"title":["Sport-related hyperhomocysteinaemia: a putative marker of muscular demand to be noted for cardiovascular risk"],"prefix":"10.1136","volume":"42","author":[{"given":"P","family":"Borrione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Spaccamiglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Salvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dovio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Termine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Fagnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Pigozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,1,23]]},"reference":[{"key":"2024051313261120000_42.11.894.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00387-3"},{"key":"2024051313261120000_42.11.894.2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051351"},{"key":"2024051313261120000_42.11.894.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.10.016"},{"key":"2024051313261120000_42.11.894.4","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200333140-00001"},{"key":"2024051313261120000_42.11.894.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000074229.93804.5C"},{"key":"2024051313261120000_42.11.894.6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/oxfordjournals.aje.a115870","article-title":"Body fat distribution in relation to physical activity and smoking habits in 38-year-old European men. 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