{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:56:01Z","timestamp":1773600961359,"version":"3.50.1"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2008,7,1]]},"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In this study, serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) between patients with a history of Achilles tendon rupture and blood donor controls were compared, and their relation to mechanical properties of the tendons during healing were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>More than 3 years after injury, serum levels of MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9 and MMP-13, TIMP-1 and TIMP-2 in eight patients who had Achilles tendon rupture were measured. Twelve blood donors served as controls. During the early phase of healing, the tendon modulus of elasticity was calculated from radiostereometric data and tendon cross-sectional area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with a history of Achilles tendon rupture had increased levels of MMP-2 (median difference 10%, p=0.01), MMP-7 (median difference 15%, p=0.02) and TIMP-2 (median difference 36%, p=0.02), compared with controls. Levels of MMP-7, measured 3 years after injury, correlated inversely to tendon modulus of elasticity (r<jats:sub>s<\/jats:sub>=20.83, p=0.02) and positively to tendon elongation (r<jats:sub>s<\/jats:sub>=0.74, p=0.05) during the early phase of healing. There was a trend towards positive correlation between MMP-7 and cross-sectional area during the early phase of healing (r<jats:sub>s<\/jats:sub>=0.67, p=0.08).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with a history of Achilles tendon rupture appear to have elevated levels of MMP-2, MMP-7 and TIMP-2 in serum. In these pilot data, the view that the MMP\u2013TIMP system is involved in tendinopathy is supported and that disturbances in proteolytic control might be generalised are suggested.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjsm.2008.049411","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T23:44:48Z","timestamp":1216165488000},"page":"669-672","source":"Crossref","is-referenced-by-count":24,"title":["Elevation of systemic matrix metalloproteinases 2 and 7 and tissue inhibitor of metalloproteinase 2 in patients with a history of Achilles tendon rupture: pilot study"],"prefix":"10.1136","volume":"44","author":[{"given":"B","family":"Pasternak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Schepull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Eliasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Aspenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,7,15]]},"reference":[{"key":"2025080115254419000_44.9.669.1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg448"},{"key":"2025080115254419000_44.9.669.2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.01850"},{"key":"2025080115254419000_44.9.669.3","doi-asserted-by":"publisher","DOI":"10.1177\/0363546507301885"},{"key":"2025080115254419000_44.9.669.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei152"},{"key":"2025080115254419000_44.9.669.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.21672"},{"key":"2025080115254419000_44.9.669.6","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506293255"},{"key":"2025080115254419000_44.9.669.7","doi-asserted-by":"crossref","unstructured":"Leppilahti J Forsman K Puranen J . Outcome and prognostic factors of Achilles rupture repair using a new scoring method. Clin Orthop Relat Res 1998:152\u00e2\u0080\u009361.","DOI":"10.1097\/00003086-199801000-00022"},{"key":"2025080115254419000_44.9.669.8","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2106\/00004623-200211000-00017","article-title":"Rerupture and deep infection following treatment of total Achilles tendon rupture","volume":"84-A","author":"Pajala","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"2025080115254419000_44.9.669.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.06.015"},{"key":"2025080115254419000_44.9.669.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.07.011"},{"key":"2025080115254419000_44.9.669.11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-8-116"},{"key":"2025080115254419000_44.9.669.12","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.238"},{"key":"2025080115254419000_44.9.669.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6634.1454"},{"key":"2025080115254419000_44.9.669.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2004.00344.x"},{"key":"2025080115254419000_44.9.669.15","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.86B5.14747"},{"key":"2025080115254419000_44.9.669.16","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.033035"},{"key":"2025080115254419000_44.9.669.17","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062018"},{"key":"2025080115254419000_44.9.669.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0255-y"},{"key":"2025080115254419000_44.9.669.19","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00384-004-0578-4","article-title":"Circulating matrix metalloproteinase-9 is transiently elevated after colorectal surgery","volume":"19","author":"de Hingh","year":"2004","journal-title":"Int J Colorectal Dis"},{"key":"2025080115254419000_44.9.669.20","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2003.007609"},{"key":"2025080115254419000_44.9.669.21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1177\/03635465000280021301","article-title":"A radiographic and histologic evaluation of the patellar tendon after harvesting its central third","volume":"28","author":"Kartus","year":"2000","journal-title":"Am J Sports Med"},{"key":"2025080115254419000_44.9.669.22","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.090"},{"key":"2025080115254419000_44.9.669.23","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.9.890"}],"container-title":["British Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjsm.2008.049411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T22:25:56Z","timestamp":1754087156000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjsm.bmj.com\/lookup\/doi\/10.1136\/bjsm.2008.049411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,15]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,6,29]]},"published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1136\/bjsm.2008.049411"],"URL":"https:\/\/doi.org\/10.1136\/bjsm.2008.049411","relation":{},"ISSN":["0306-3674","1473-0480"],"issn-type":[{"value":"0306-3674","type":"print"},{"value":"1473-0480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,15]]}}}