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Search strategy: names and descriptors of the therapies and LE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Selection:<\/jats:title><jats:p>All human studies assessing the four therapies for LE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results:<\/jats:title><jats:p>Results of five prospective case series and four controlled trials (three prolotherapy, two polidocanol, three autologous whole blood and one platelet-rich plasma) suggest each of the four therapies is effective for LE. In follow-up periods ranging from 9 to 108 weeks, studies reported sustained, statistically significant (p&lt;0.05) improvement in visual analogue scale primary outcome pain score measures and disease-specific questionnaires; relative effect sizes ranged from 51% to 94%; Cohen\u2019s d ranged from 0.68 to 6.68. Secondary outcomes also improved, including biomechanical elbow function assessment (polidocanol and prolotherapy), presence of abnormalities and increased vascularity on ultrasound (autologous whole blood and polidocanol). Subjects reported satisfaction with therapies on single-item assessments. All studies were limited by small sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>There is strong pilot-level evidence supporting the use of prolotherapy, polidocanol, autologous whole blood and platelet-rich plasma injections in the treatment of LE. Rigorous studies of sufficient sample size, assessing these injection therapies using validated clinical, radiological and biomechanical measures, and tissue injury\/healing-responsive biomarkers, are needed to determine long-term effectiveness and safety, and whether these techniques can play a definitive role in the management of LE and other tendinopathies.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjsm.2008.052761","type":"journal-article","created":{"date-parts":[[2008,11,22]],"date-time":"2008-11-22T01:34:37Z","timestamp":1227317677000},"page":"471-481","source":"Crossref","is-referenced-by-count":137,"title":["A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma"],"prefix":"10.1136","volume":"43","author":[{"given":"D","family":"Rabago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E","family":"Zgierska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Zeisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Crane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,11,21]]},"reference":[{"key":"2024051313394033000_43.7.471.1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00180221","article-title":"Tennis elbow: anatomical, epidemiological and therapeutic aspects.","volume":"18","author":"Verhar","year":"1994","journal-title":"Int Orthop"},{"key":"2024051313394033000_43.7.471.2","first-page":"464","article-title":"The prevalence of humeral epicondylitis: a survey in general practice.","volume":"36","author":"Hamilton","year":"1986","journal-title":"J R Coll Gen Pract"},{"key":"2024051313394033000_43.7.471.3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2340\/165019771983153741","article-title":"The etiology and conservative treatment of lateral epicondylitis.","volume":"15","author":"Kivi","year":"1983","journal-title":"Scand J Rehabil Med"},{"key":"2024051313394033000_43.7.471.4","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.3.172"},{"key":"2024051313394033000_43.7.471.5","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.64"},{"key":"2024051313394033000_43.7.471.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90300-7"},{"key":"2024051313394033000_43.7.471.7","first-page":"90","article-title":"Tennis elbow.","volume":"17","author":"Murtaugh","year":"1988","journal-title":"Aust Fam Phys"},{"key":"2024051313394033000_43.7.471.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(98)70021-0"},{"key":"2024051313394033000_43.7.471.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7338.626"},{"key":"2024051313394033000_43.7.471.10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1148\/radiology.196.1.7784585","article-title":"Lateral epicondylitis: Correlation of MR imaging, surgical and histopathological findings.","volume":"196","author":"Potter","year":"1995","journal-title":"Radiology"},{"key":"2024051313394033000_43.7.471.11","first-page":"1399","article-title":"\u2018Lateral elbow tendinopathy\u2019 is the most appropriate diagnostic term for the condition commonly referred to as lateral epicondylitis.","volume":"67","author":"Stasinapoulos","year":"2006","journal-title":"Medical Hypotheses"},{"key":"2024051313394033000_43.7.471.12","first-page":"269","article-title":"Tendinitis of the elbow (tennis elbow). 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