{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:38:26Z","timestamp":1773459506562,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Sports Med"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>Peripheral chemoreceptors (carotid bodies) are the main sensing organs for hypoxaemia. During carotid surgery, the carotic body in the bifurcation of the common carotid artery is often involved and damaged or destroyed. Animals lose their ability to adapt to high altitude after experimental denervation of the carotid bodies. The objective of our study was to evaluate the ability of human patients to adapt to moderate altitude after single side carotid surgery. Blood gas analysis at rest at 171 m and after car and cable car transport to 1600 m before and after carotid surgery was performed. Mean(s.d.) paO2 decreased insignificantly from 74.8(3.56) at 171 m altitude to 71.6(2.07) at 1600 m (P = n.s.), means(s.d.) paCO2 decreased significantly from 36.2(2.86) to 31.4(2.7) mmHg (P &lt; 0.05) before carotid surgery. Months after surgery, a significant drop in paO2 occurred after identical passive exposure to moderate altitude: mean(s.d.) paCO2 at 171 m 74.4(3.65) mmHg, at 1600 m 65.8(3.70) mmHg (P &lt; 0.01), paCO2 did not change significantly. Mean(s.d.) paCO2 at 171 m: 36.0(2.35), at 1600 m 36.2(2.86) mmHg (P = n.s.). Although the sample investigated was small, after single side carotid surgery patients seem to lose their ability for satisfactory ventilatory response to acute exposure to moderate altitude. This is of possible alpine medical importance.<\/jats:p>","DOI":"10.1136\/bjsm.29.2.110","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T19:55:24Z","timestamp":1229370924000},"page":"110-112","source":"Crossref","is-referenced-by-count":18,"title":["Poor ventilatory response to mild hypoxia may inhibit acclimatization at moderate altitude in elderly patients after carotid surgery."],"prefix":"10.1136","volume":"29","author":[{"given":"G","family":"Roeggla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Roeggla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A N","family":"Laggner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jama.1989.03420070095039","article-title":"Will mountain trekkers have heart attacks?","volume":"261","author":"Drummond, R.","year":"1989","unstructured":"Drummond R Will mountain trekkers have heart attacks? JAMA 1989; 261: 1045-6.","journal-title":"JAMA"},{"key":"ref_2","article-title":"Angiology: surgical therapy","author":"Kappert, A.","year":"1976","unstructured":"Kappert A. Angiology: surgical therapy. Bern, Switzerland: Hans Huber Verlag, 1976."},{"key":"ref_3","article-title":"High altitude medicine and physiology","author":"Ward, M.P.; Milledge, J.S.; West, J.B.","year":"1989","unstructured":"Ward MP, Milledge JS, West JB. High altitude medicine and physiology. London, UK: Chapman and Hall. 1989."},{"key":"ref_4","article-title":"Die osterreichische Standardisierung der Blutgasanalyse","author":"K, Haber P.Harnoncourt; G, Forche","unstructured":"Haber P. Harnoncourt K, Forche G. Die osterreichische Standardisierung der Blutgasanalyse. Osterr Arztezeitung 1988; 43: 32 and 53-8."},{"key":"ref_5","article-title":"Lungenfunktion","author":"Ulmer, W.T.; Reichel, G.; Nolte, D.","year":"1976","unstructured":"Ulmer WT, Reichel G, Nolte D. Lungenfunktion. Stuttgart, Germany: Thieme, 1976."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1001\/jama.260.15.2219","article-title":"Trekking in Nepal: safety after coronary artery bypass","volume":"260","author":"Froelicher, V.F.; West, G.B.","year":"1988","unstructured":"Froelicher VF, West GB. Trekking in Nepal: safety after coronary artery bypass. JAMA 1988; 260: 2219-9.","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/00042752-199104000-00004","article-title":"Cardiovascular screening for high altitude trekking","volume":"1","author":"Morris, C.K.; Froelicher, V.F.","year":"1991","unstructured":"Morris CK, Froelicher VF. Cardiovascular screening for high altitude trekking. Clin I Sport Med 1991; 1: 100-3.","journal-title":"Clin I Sport Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM199108153250701","article-title":"North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high grade carotid stenosis","volume":"325","year":"1991","unstructured":"North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high grade carotid stenosis. N Engl J Med 1991; 325: 445-53.","journal-title":"N Engl J Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1152\/jappl.1993.74.2.805","article-title":"Ventilatory response to moderate hypoxia in awake chemodenerved cats","volume":"74","author":"GG, Long W.Q.Giesbrecht; NR, Anthonisen","year":"1993","unstructured":"Long WQ Giesbrecht GG, Anthonisen NR. Ventilatory response to moderate hypoxia in awake chemodenerved cats. J Appl Physiol 1993; 74: 805-10.","journal-title":"J Appl Physiol"},{"key":"ref_10","article-title":"Lunge und Atmung","author":"Buehlmann, A.A.","year":"1987","unstructured":"Buehlmann AA. Lunge und Atmung. In: Siegentaler, E, ed. Klinische Pathophysiologie. Stuttgart, Germany: Thieme Verlag, 1987."},{"issue":"2","key":"ref_11","article-title":"Sp Med","volume":"29","author":"Br, J.","year":"1995","unstructured":"Br J Sp Med 1995; 29(2)"}],"container-title":["British Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjsm.29.2.110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T20:20:51Z","timestamp":1754079651000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjsm.bmj.com\/lookup\/doi\/10.1136\/bjsm.29.2.110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1995,6,1]]},"published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1136\/bjsm.29.2.110"],"URL":"https:\/\/doi.org\/10.1136\/bjsm.29.2.110","relation":{},"ISSN":["0306-3674","1473-0480"],"issn-type":[{"value":"0306-3674","type":"print"},{"value":"1473-0480","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}