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Morning urinary levels of 6-sulphatoxymelatonin (aMT6s) and morning serum levels of testosterone, follicle stimulating (FSH), luteinising hormone (LH), and cortisol were measured in each subject at t<jats:sub>0<\/jats:sub>(before the competition), t<jats:sub>1<\/jats:sub>(end of first week), t<jats:sub>2<\/jats:sub>(end of second week), and t<jats:sub>3<\/jats:sub>(end of third week). Urine samples of aMT6s were also evaluated in the evening at t<jats:sub>0<\/jats:sub>, t<jats:sub>1<\/jats:sub>, t<jats:sub>2<\/jats:sub>, and t<jats:sub>3<\/jats:sub>.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>\u2014Mean urinary aMT6s levels had increased significantly (p&lt;0.01) during the day after each stage (1091 (33)<jats:italic>v<\/jats:italic>683 (68) ng\/ml at t<jats:sub>1<\/jats:sub>; 955 (19)<jats:italic>v<\/jats:italic>473 (53) ng\/ml at t<jats:sub>2<\/jats:sub>; 647 (61)<jats:italic>v<\/jats:italic>337 (47) ng\/ml at t<jats:sub>3<\/jats:sub>). Both morning and evening aMT6s levels decreased significantly during the study. A similar pattern was observed for morning serum levels of cortisol and testosterone.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>\u2014The results suggest that the basal activity of the pineal gland, adrenal glands, and testis may be decreased after consecutive days of intense, long term exercise.<\/jats:p>","DOI":"10.1136\/bjsm.35.6.424","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:32:19Z","timestamp":1027765939000},"page":"424-430","source":"Crossref","is-referenced-by-count":85,"title":["Hormone levels of world class cyclists during the Tour of Spain stage race"],"prefix":"10.1136","volume":"35","author":[{"given":"A","family":"Luc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hoyos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Bandr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Chicharro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2024051400463558000_35.6.424.1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(91)90087-9"},{"key":"2024051400463558000_35.6.424.2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/sleep\/24.3.272","volume":"24","year":"2001","journal-title":"Sleep"},{"key":"2024051400463558000_35.6.424.3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-53-1-223"},{"key":"2024051400463558000_35.6.424.4","doi-asserted-by":"publisher","DOI":"10.3109\/00016348609157031"},{"key":"2024051400463558000_35.6.424.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1989.tb00666.x"},{"key":"2024051400463558000_35.6.424.6","first-page":"838","volume":"66","year":"1984","journal-title":"S Afr Med J"},{"key":"2024051400463558000_35.6.424.7","first-page":"17","volume":"49","year":"1993","journal-title":"Rev Esp Fisiol"},{"key":"2024051400463558000_35.6.424.8","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-3-540"},{"key":"2024051400463558000_35.6.424.9","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(79)90018-0"},{"key":"2024051400463558000_35.6.424.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237782"},{"key":"2024051400463558000_35.6.424.11","unstructured":"Murray RG, Hackney AC. 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