{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:18:07Z","timestamp":1774581487014,"version":"3.50.1"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2013,9,13]]},"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                  <jats:title>Rationale<\/jats:title>\n                  <jats:p>Salbutamol may affect lung function and exercise performance differently in individuals with and without asthma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To compare the effects of inhaled salbutamol on lung function, exercise performance and respiratory parameters during cycling exercise in athletes with a positive response to a eucapnic voluntary hyperpnoea (EVH+) and negative (EVH\u2212) challenge, indicative of exercise-induced bronchoconstriction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a randomised controlled trial with a crossover design, a total of 49 well-trained male athletes (14 EVH+ and 35 EVH\u2212) performed two simulated 10\u2005km time-trials on a cycle ergometer 60\u2005min after the inhalation of either 400\u2005\u03bcg of salbutamol or a placebo. Lung function, assessed by forced expiratory volume in 1\u2005s, was measured immediately before and 30\u2005min after inhalation. Performance was measured by mean power output.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Measurements &amp; main results<\/jats:title>\n                  <jats:p>Despite a significant increase in lung function after the inhalation of salbutamol compared to the placebo (p&lt;0.001), salbutamol did not affect athletes\u2019 perceptions of dyspnoea (p&gt;0.05) or leg exertion (p&gt;0.05) during exercise. Salbutamol did not affect mean power output: EVH+ and EVH\u2212 athletes averaged 4.0 (0.5) and 4.1 (0.5) W\/kg after salbutamol and 4.0 (0.5) W\/kg and 4.0 (0.4) W\/kg after placebo, respectively (p&gt;0.05 for each comparison).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The inhalation of salbutamol induced a significant increase in resting lung function in EVH+ and EVH\u2212 athletes but this improvement in lung function did not translate to improved exercise performance. Salbutamol had no discernible effect on key ventilatory and exercise parameters regardless of EVH challenge outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjsports-2013-092706","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T20:49:57Z","timestamp":1381178997000},"page":"51-55","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Inhaled salbutamol does not affect athletic performance in asthmatic and non-asthmatic cyclists"],"prefix":"10.1136","volume":"49","author":[{"given":"Sarah","family":"Koch","sequence":"first","affiliation":[{"name":"School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J","family":"MacInnis","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C","family":"Sporer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Canadian Sport Institute, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L","family":"Rupert","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S","family":"Koehle","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"2025080114350844000_49.1.51.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01662.x"},{"key":"2025080114350844000_49.1.51.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2011-090814"},{"key":"2025080114350844000_49.1.51.3","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.164"},{"key":"2025080114350844000_49.1.51.4","doi-asserted-by":"crossref","unstructured":"Fitch KD Sue-Chu M Anderson SD . Asthma and the elite athlete: summary of the International Olympic Committee's consensus conference; Lausanne, Switzerland: 2008:254\u201360\u2013260.e1\u20137.","DOI":"10.1016\/j.jaci.2008.07.003"},{"key":"2025080114350844000_49.1.51.5","doi-asserted-by":"publisher","DOI":"10.2165\/11537540-000000000-00000"},{"key":"2025080114350844000_49.1.51.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01663.x"},{"key":"2025080114350844000_49.1.51.7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00007256-200737020-00001","article-title":"Do inhaled 2-agonists have an ergogenic potential in non-asthmatic competitive athletes?","volume":"116","author":"Kindermann","year":"2007","journal-title":"Sports Med"},{"key":"2025080114350844000_49.1.51.8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815716"},{"key":"2025080114350844000_49.1.51.9","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1249\/00005768-199210000-00015","article-title":"The effect of salbutamol on performance in elite nonasthmatic athletes","volume":"24","author":"Meeuwisse","year":"1992","journal-title":"Med Sci Sports Exerc"},{"key":"2025080114350844000_49.1.51.10","first-page":"144","article-title":"Enhancement of exercise performance with inhaled albuterol","volume":"13","author":"Bedi","year":"1988","journal-title":"Can J Sport Sci"},{"key":"2025080114350844000_49.1.51.11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0838.1999.tb00206.x","article-title":"Salmeterol and physical performance at -15 degrees C in highly trained nonasthmatic cross-country skiers","volume":"9","author":"Sue-Chu","year":"1999","journal-title":"Scand J Med Sci Sports"},{"key":"2025080114350844000_49.1.51.12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1249\/mss.0b013e3181591df7","article-title":"Dose response of inhaled salbutamol on exercise performance and urine concentrations","volume":"40","author":"Sporer","year":"2007","journal-title":"Med Sci Sports Exerc"},{"key":"2025080114350844000_49.1.51.13","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.35.5.344"},{"key":"2025080114350844000_49.1.51.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2025080114350844000_49.1.51.15","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1815"},{"key":"2025080114350844000_49.1.51.16","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199712000-00013"},{"key":"2025080114350844000_49.1.51.17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972999"},{"key":"2025080114350844000_49.1.51.18","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050337"},{"key":"2025080114350844000_49.1.51.19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00562.2009"}],"container-title":["British Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjsports-2013-092706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T21:35:25Z","timestamp":1754084125000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjsm.bmj.com\/lookup\/doi\/10.1136\/bjsports-2013-092706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,7]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,15]]},"published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1136\/bjsports-2013-092706"],"URL":"https:\/\/doi.org\/10.1136\/bjsports-2013-092706","relation":{},"ISSN":["0306-3674","1473-0480"],"issn-type":[{"value":"0306-3674","type":"print"},{"value":"1473-0480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,7]]}}}