{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:11:02Z","timestamp":1790799062772,"version":"4.1.0"},"reference-count":58,"publisher":"BMJ","issue":"14","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2017,3,12]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the effects of cardiorespiratory and strength exercises on disease activity for patients with inflammatory rheumatic diseases (IRDs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A systematic review with meta-analysis registered at PROSPERO (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"CRD42015020004\">CRD42015020004<\/jats:ext-link>).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Patients with IRDs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data sources<\/jats:title>\n                  <jats:p>The databases MEDLINE, AMED, Embase and CINAHL were searched from inception up to April 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Eligibility criteria for selecting studies<\/jats:title>\n                  <jats:p>Trials were included if they were randomised controlled trials of adults with IRDs, comparing the effect of cardiorespiratory and strength exercises with usual care on disease activity and followed the American College of Sports Medicine's exercise recommendations. The primary outcome was disease activity in terms of inflammation, joint damage and symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data synthesis<\/jats:title>\n                  <jats:p>Data were pooled in a random-effect model for all outcomes, and standardised mean differences (SMDs) were calculated. The quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-six trials with a total of 1286 participants were included. There was high to moderate quality evidence, for a small beneficial effect on disease activity scores (0.19 (95% CI 0.05 to 0.33), p&lt;0.01) and joint damage (SMD 0.27 (95% CI 0.07 to 0.46), p&lt;0.01). Furthermore, moderate quality evidence for a small beneficial effect on erythrocyte sedimentation rate (SMD 0.20 (95% CI 0.0 to 0.39), p=0.04) and for no effect on C reactive protein (SMD \u22120.14 (95% CI \u22120.37 to 0.08), p=0.21). Beneficial effects were also seen for symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results of this review suggest beneficial effects of exercises on inflammation, joint damage and symptoms in patients with IRDs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjsports-2016-097149","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T20:55:23Z","timestamp":1493412923000},"page":"1065-1072","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":122,"title":["Effect of cardiorespiratory and strength exercises on disease activity in patients with inflammatory rheumatic diseases: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"51","author":[{"given":"Silje Halvorsen","family":"Sveaas","sequence":"first","affiliation":[{"name":"Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway"},{"name":"Department of Health Sciences, Institute of Health and Society, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Smedslund","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway"},{"name":"The Norwegian Knowledge Center for the Health Services, The Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re Birger","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway"},{"name":"Department of Health Sciences, Institute of Health and Society, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Dagfinrud","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway"},{"name":"Department of Health Sciences, Institute of Health and Society, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"2025080113312722000_51.14.1065.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61499-3"},{"key":"2025080113312722000_51.14.1065.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.04.016"},{"key":"2025080113312722000_51.14.1065.3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu403"},{"key":"2025080113312722000_51.14.1065.4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/BOR.0000000000000284","article-title":"Treat-to-target as an approach in inflammatory arthritis","volume":"28","author":"Smolen","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"2025080113312722000_51.14.1065.5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203419"},{"key":"2025080113312722000_51.14.1065.6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/acr.20415","article-title":"Exercise programs in trials for patients with ankylosing spondylitis: do they really have the potential for effectiveness?","volume":"63","author":"Dagfinrud","year":"2011","journal-title":"Arthritis Care Res"},{"key":"2025080113312722000_51.14.1065.7","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public Health Rep"},{"key":"2025080113312722000_51.14.1065.8","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"2025080113312722000_51.14.1065.9","first-page":"6","article-title":"Position statement. part one: immune function and exercise","volume":"17","author":"Walsh","year":"2011","journal-title":"Exerc Immunol Rev"},{"key":"2025080113312722000_51.14.1065.10","doi-asserted-by":"crossref","unstructured":"Fedewa MV , Hathaway ED , Ward-Ritacco CL . 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