{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:34:41Z","timestamp":1790876081130,"version":"4.1.0"},"reference-count":37,"publisher":"BMJ","issue":"22","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2019,2,1]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence on the role of very low or very high volumes of leisure time physical activity (PA) on the risk of all-cause and cause-specific mortality is limited. We aimed to examine the associations of different levels of leisure time PA with the risk of all-cause, cardiovascular disease (CVD) and cancer-specific mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from 12 waves of the National Health Interview Surveys (1997\u20132008) linked to the National Death Index records through 31 December 2011. A total of 88\u2009140 eligible participants aged 40\u201385 years were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with inactive individuals, those performing 10\u201359\u2009min\/week of PA had 18% lower risk of all-cause mortality (hazard ratio (HR): 0.82, 95% confidence interval (CI): 0.72\u20130.95). Those who reported 1\u20132 times (150\u2013299\u2009min\/week) the recommended level of leisure time PA had 31% (HR: 0.69, 95%CI: 0.63\u20130.75) reduced risk of all-cause mortality. Importantly, the continued benefits were observed among those performing leisure time PA 10 or more times (\u22651500 min\/week) the recommended minimum level (HR: 0.54, 95%\u2009CI: 0.45\u20130.64). For 10\u201359, 150\u2013299 and \u22651500\u2009min\/week of PA, the corresponding HRs (95% CIs) for CVD-specific mortality were 0.88 (0.67\u20131.17), 0.63 (0.52\u20130.78) and 0.67 (0.45\u20130.99), respectively: for cancer-specific mortality were 0.86 (0.66\u20131.11), 0.76 (0.64\u20130.89) and 0.53 (0.39\u20130.73), respectively. In addition, there was a larger reduction in all-cause and cause-specific mortality for vigorous vs. moderate intensity PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that beneficial association between leisure time PA and mortality starts from a low dose. Doing more vigorous exercise could lead to additional health benefits.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjsports-2018-099254","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T03:55:22Z","timestamp":1553054122000},"page":"1405-1411","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Beneficial associations of low and large doses of leisure time physical activity with all-cause, cardiovascular disease and cancer mortality: a national cohort study of 88,140 US adults"],"prefix":"10.1136","volume":"53","author":[{"given":"Min","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas P","family":"Veeranki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn M","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-5585","authenticated-orcid":false,"given":"Bo","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"2024051413345603000_53.22.1405.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.010710"},{"key":"2024051413345603000_53.22.1405.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61031-9"},{"key":"2024051413345603000_53.22.1405.3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29828"},{"key":"2024051413345603000_53.22.1405.4","unstructured":"Physical Activity Guidelines Advisory Committee. 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