{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:55:34Z","timestamp":1791633334942,"version":"4.3.4"},"reference-count":38,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/501100009457","name":"Region Sj\u00e6lland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["801790"],"award-info":[{"award-number":["801790"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2020,5,25]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate changes in analgesic use before and after supervised exercise therapy and patient education in patients with knee or hip osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 16 499 of 25 933 eligible patients (64%; mean age 64.9; SD 9.6; 73% women) from the Good Life with osteoArthritis in Denmark (GLA:D) registry. Change in proportions of analgesic users (categorised according to analgesic risk profile; opioids &gt; non-steroidal anti-inflammatory drugs &gt; paracetamol) was assessed from before to after an 8-week supervised exercise therapy and patient education programme targeting knee or hip OA pain and functional limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients reported 13.2 mm (95% CI 12.8 to 13.6) less pain (visual analogue scale 0\u2013100 mm) at follow-up compared with baseline. The proportion of analgesic users reduced from 62.2% (95% CI 61.5 to 63.0) at baseline to 44.1% (95% CI 43.3 to 44.9) at follow-up (absolute change: 18.1% (95% CI 17.3 to 19.0)). Among patients using analgesics at baseline, 52% changed to a lower risk analgesic or discontinued analgesic use. The proportion of opioid users after the exercise therapy was 2.5% (95% CI 2.1 to 2.9) lower than baseline; this represents a relative reduction of 36%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with knee or hip OA using analgesics, more than half either discontinued analgesic use or shifted to lower risk analgesics following an 8-week structured exercise therapy and patient education programme (GLA:D). These data encourage randomised controlled trial evaluation of whether supervised exercise therapy, combined with patient education, can reduce analgesic use, including opioids, among patients with knee and hip OA pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjsports-2019-101265","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T17:25:17Z","timestamp":1600709117000},"page":"670-675","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Patients use fewer analgesics following supervised exercise therapy and patient education: an observational study of 16\u2009499 patients with knee or hip osteoarthritis"],"prefix":"10.1136","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7789-8224","authenticated-orcid":false,"given":"Jonas Bloch","family":"Thorlund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-2199","authenticated-orcid":false,"given":"Ewa M","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Goro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Gromelsky","family":"Ljungcrantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Thalund","family":"Gr\u00f8nne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-7059","authenticated-orcid":false,"given":"S\u00f8ren T","family":"Skou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"2024101322051728000_55.12.670.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"2024101322051728000_55.12.670.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.01.003"},{"key":"2024101322051728000_55.12.670.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202745"},{"key":"2024101322051728000_55.12.670.4","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22891"},{"key":"2024101322051728000_55.12.670.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3785-3"},{"key":"2024101322051728000_55.12.670.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex270"},{"key":"2024101322051728000_55.12.670.7","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001509"},{"key":"2024101322051728000_55.12.670.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.01.005"},{"key":"2024101322051728000_55.12.670.9","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22360"},{"key":"2024101322051728000_55.12.670.10","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23933"},{"key":"2024101322051728000_55.12.670.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.0899"},{"key":"2024101322051728000_55.12.670.12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/pme.12904","article-title":"Prescription opioid misuse, abuse, morbidity, and mortality: balancing effective pain management and safety","volume":"16 Suppl 1","author":"Cheatle","year":"2015","journal-title":"Pain Med"},{"key":"2024101322051728000_55.12.670.13","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.450"},{"key":"2024101322051728000_55.12.670.14","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051528"},{"key":"2024101322051728000_55.12.670.15","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-019-00660-1"},{"key":"2024101322051728000_55.12.670.16","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-019-00664-x"},{"key":"2024101322051728000_55.12.670.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.002"},{"key":"2024101322051728000_55.12.670.18","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0865"},{"key":"2024101322051728000_55.12.670.19","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3776"},{"key":"2024101322051728000_55.12.670.20","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1439-y"},{"key":"2024101322051728000_55.12.670.21","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"2024101322051728000_55.12.670.22","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.113100"},{"key":"2024101322051728000_55.12.670.23","unstructured":"Authority TDH . 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