{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:13:30Z","timestamp":1793776410660,"version":"4.6.1"},"reference-count":99,"publisher":"BMJ","issue":"24","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2022,9,19]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Determine the long-term health-related quality-of-life (HRQoL), work limitation, physical activity, health\/economic cost and disease burden of traumatic ACL and\/or meniscal injury. Findings will inform OPTIKNEE evidence-based consensus recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Random-effects meta-analysis evaluated HRQoL (SF-36\/SF-12\/VR-12 Physical Component Scores (PCS) and Mental Component Scores (MCS), EuroQol-5D (EQ-5D)) stratified by time postinjury, and pooled mean differences (95%\u2009CI) between ACL-injured and uninjured controls. Other outcomes were synthesised descriptively. Risk-of-bias (RoB) and certainty of evidence (Grading of Recommendations Assessment, Development and Evaluation) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, CENTRAL, SPORTDiscus, CINAHL searched inception: 22 November 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility<\/jats:title>\n                    <jats:p>Studies reporting HRQoL, work limitations, physical activity levels, health\/economic costs or disease burden, \u22652 years post-ACL and\/or meniscal injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty studies were included (10 high-RoB, 28 susceptible-to-some-bias and 12 low-RoB). Meta-analysis (27 studies, very low certainty of evidence) estimated a pooled mean (95%\u2009CI) PCS of 52.4 (51.4 to 53.4) and MCS of 54.0 (53.0 to 55.0) 2\u201314 years post-ACL injury. Pooled PCS scores were worse &gt;10 years (50.8 (48.7 to 52.9)) compared with 2\u20135 years (53.9 (53.1 to 54.7)) postinjury. Excluding high-RoB studies, PCS scores were worse in ACL-injured compared with uninjured controls (\u22121.5 (\u22122.9 to \u20130.1)). Six studies (low certainty of evidence) informed a pooled EQ-5D score of 0.83 (0.81 to 0.84). Some individuals experienced prolonged work absenteeism and modified activities \u22652 years post-ACL injury. ACL injury was associated with significant direct and indirect costs, and early ACL reconstruction may be less cost-effective than rehabilitation. Only three studies evaluated meniscal injury outcomes (all evaluated HRQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a very-low certainty of evidence that PCS scores \u22652 years post-ACL injury are worse than uninjured controls and decline over time, whereas MCS scores remain high. ACL injury can result in prolonged work absenteeism and high health\/economic costs. Further studies are needed to determine the long-term burden of traumatic meniscal injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjsports-2022-105626","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:44:03Z","timestamp":1664372643000},"page":"1465-1474","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["Long-term quality of life, work limitation, physical activity, economic cost and disease burden following ACL and meniscal injury: a systematic review and meta-analysis for the OPTIKNEE consensus"],"prefix":"10.1136","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9624-0791","authenticated-orcid":false,"given":"Stephanie Rose","family":"Filbay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-7059","authenticated-orcid":false,"given":"S\u00f8ren T","family":"Skou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett S","family":"Bullock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-5157","authenticated-orcid":false,"given":"Christina Y","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-8169","authenticated-orcid":false,"given":"Anu M","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh","family":"Toomey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M","family":"Ezzat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-0264","authenticated-orcid":false,"given":"Adam G","family":"Culvenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-4976","authenticated-orcid":false,"given":"Jackie L","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-2199","authenticated-orcid":false,"given":"Ewa M","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5892-129X","authenticated-orcid":false,"given":"Kay M","family":"Crossley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten Bogh","family":"Juhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-6691","authenticated-orcid":false,"given":"Carolyn","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"2024051422420278000_56.24.1465.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2010.076364"},{"key":"2024051422420278000_56.24.1465.2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513512774"},{"key":"2024051422420278000_56.24.1465.3","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-094864"},{"key":"2024051422420278000_56.24.1465.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.025"},{"key":"2024051422420278000_56.24.1465.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-004-0591-8"},{"key":"2024051422420278000_56.24.1465.6","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-093398"},{"key":"2024051422420278000_56.24.1465.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2016.02.011"},{"key":"2024051422420278000_56.24.1465.8","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12698"},{"key":"2024051422420278000_56.24.1465.9","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2018-100022"},{"key":"2024051422420278000_56.24.1465.10","doi-asserted-by":"publisher","DOI":"10.1177\/2325967116634074"},{"key":"2024051422420278000_56.24.1465.11","doi-asserted-by":"publisher","DOI":"10.1177\/1941738111429419"},{"key":"2024051422420278000_56.24.1465.12","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2019-100959"},{"key":"2024051422420278000_56.24.1465.13","unstructured":"Higgins JPT TJ , Chandler J , Cumpston M , et al . 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